Would the Physicians Eventually Obsolete the Liver Biopsy for the Assessment of Liver Fibrosis?

Parsian, Hadi; Alizadeh, Maryam; Negahdar, Hajar

doi:10.5812/hepatmon.6227

Cited by 5 publications

(2 citation statements)

References 7 publications

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“…Liver biopsy still has an important role in the estimation of liver fibrosis stage, but it is not very far that this invasive method will completely replace with the other noninvasive methods such as serum based biomarkers [70]. Therefore development of non-invasive methods is still needed and we should work harder for finding an appropriate method.…”

Section: Resultsmentioning

confidence: 99%

Clinical Application of Non-Invasive Markers of Liver Fibrosis

Parsian¹,

Alizadeh²,

Yahyapour³

2013

Practical Management of Chronic Viral Hepatitis

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Section: Resultsmentioning

confidence: 99%

Clinical Application of Non-Invasive Markers of Liver Fibrosis

Parsian¹,

Alizadeh²,

Yahyapour³

2013

Practical Management of Chronic Viral Hepatitis

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“…All of these factors can lead to a misdiagnosis of the “fibrosis” that is present. However, the combination with serum marker of fibrosis can increase the usefulness of the LSM in clinical practice, although with a potential increase of costs (9). Despite these intrinsic limitations, the use of LSM was introduced both in Europe and in the USA with an explicit role in the evaluation of transplanted liver (10, 11).…”

Section: Introductionmentioning

confidence: 99%

Serial Liver Stiffness Measurements and Monitoring of Liver-Transplanted Patients in a Real-Life Clinical Practice

Rinaldi¹,

Valente²,

Piai³

2016

Hepat Mon

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BackgroundLiver transplanted patients need close surveillance for early signs of graft disease.ObjectivesTransient elastography can safely be repeated over time, offering serial liver stiffness measurement values. Serial stiffness measurements were compared to single baseline stiffness measurements in predicting the appearance of liver-related clinical events and guiding subsequent clinical decisions.MethodsOne hundred and sixty liver transplanted patients were observed for three years in our real-life practice.ResultsLiver stiffness measurements were stable in 75% of patients, decreased in 4% of patients, and increased in 21% of patients. The pattern of increased stiffness measurements was associated with both HCV-RNA positive status and the presence of an active biliary complication of liver transplantation and was more predictive of a clinically significant event resulting from any disease of the transplanted liver when compared to a stable pattern or to a single liver stiffness measurement. The procedures that were consequently performed were often diagnostic for unexpected situations, both in HCV-RNA positive and HCV-RNA negative patients.ConclusionsThe pattern of longitudinally increased liver stiffness measurements efficiently supported clinical decisions for individualized management strategies. Repeated transient elastography in real-life clinical practice appears to have a practical role in monitoring liver transplanted patients.

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Hyaluronic acid algorithm-based models for assessment of liver fibrosis: translation from basic science to clinical application

Babaei

Parsian

2016

Hepatobiliary & Pancreatic Diseases International

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Would the Physicians Eventually Obsolete the Liver Biopsy for the Assessment of Liver Fibrosis?

Cited by 5 publications

References 7 publications

Clinical Application of Non-Invasive Markers of Liver Fibrosis

Clinical Application of Non-Invasive Markers of Liver Fibrosis

Serial Liver Stiffness Measurements and Monitoring of Liver-Transplanted Patients in a Real-Life Clinical Practice

Hyaluronic acid algorithm-based models for assessment of liver fibrosis: translation from basic science to clinical application

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