Would thyroid binding globulin compensate for albumin loss during pregnancy?

Yatama, Fatima Al; Mohammed, F.; Thani, Hess; Masoud, Fatima Al

doi:10.1530/endoabs.41.ep687

Cited by 2 publications

(4 citation statements)

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“…In pregnancy, serum albumin levels may be decreased in cases of renal insu ciency with proteinuria, pre-eclampsia, gestational hypertension and gestational edema. Therefore, there is a supposition, consistent with other authors, that proteinuria and low serum ALB may lead to low fT3 and fT4 levels with adverse effects on fetal development [12,15,17,18,19,20,21].…”

Section: Discussionsupporting

confidence: 76%

“…ALB, along thyroxine-binding globulin (TBG) and transthyretin, is a major transport protein transporting thyroid hormones in the vascular bed. TBG concentration is negatively correlated with ALB concentration which means that a signi cant increase in the concentration of TBG in pregnancy leads to decreases in the concentrations of ALB [2,15]. A slight decrease in the serum concentration of ALB in pregnancy is considered normal [16], but signi cantly lower ALB levels in the third trimester of pregnancy were associated with increased maternal and neonatal mortality and morbidity [12].…”

Section: Discussionmentioning

confidence: 99%

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Associations Between The Thyroid Panel and Serum Protein Concentrations Across Pregnancy

Lisowska-Myjak

Strawa

Zborowska

et al. 2020

Preprint

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Background: Establishing any characteristic associations between the serum parameters of thyroid function and serum proteins in pregnancy may aid in elucidating the role of the thyroid gland in the regulation of pregnancy-specific metabolic processes and in selecting candidate biomarkers for use in their clinical assessment.Methods: Concentrations of thyroid stimulating hormone (TSH), free tri-iodothyronine (fT3) and free thyroxine (fT4), six electrophoretically separated protein fractions (albumin, alpha-1-, alpha-2-, beta-1-, beta-2- and gamma-globulins), representative proteins - albumin (ALB), transferrin (TRF), alpha-2-macroglobulin (AMG) and ceruloplasmin (CER) were measured in 136 serum samples from 65 women in their consecutive trimesters of pregnancy.Results: The concentrations of TSH, fT4 and fT3 were significantly correlated (p<0.05) with the concentrations of the albumin, alpha-2- and beta-1 globulin fractions. Significant correlations (p<0.05) which were positive between fT4 and ALB and negative between fT4 and TRF were established throughout pregnancy. Significant negative correlations (p<0.05) were demonstrated for fT3 with alpha-2-globulin, AMG and CER.Conclusions: Changes in the serum concentrations of thyroid hormones seen between the trimesters were found to correlate with the concentrations of high-abundance serum proteins. Opposite directions of correlations between fT4 and ALB and fT4 and TRF observed throughout pregnancy may indicate the shared biological role of these parameters in maintaining maternal homeostasis and they suggest their potential use in the clinic as a simple biomarker panel. A negative correlation of fT3 with CER in the second trimester possibly reflects their involvement in the active regulation of metabolic processes.

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Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Associations Between The Thyroid Panel and Serum Protein Concentrations Across Pregnancy

Lisowska-Myjak

Strawa

Zborowska

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…ALB, along thyroxine-binding globulin (TBG) and transthyretin, is a major transport protein transporting thyroid hormones in the vascular bed. TBG concentration is negatively correlated with ALB concentration which means that a significant increase in the concentration of TBG in pregnancy leads to decreases in the concentrations of ALB 2,15 . A slight decrease in the serum concentration of ALB in pregnancy is considered normal 16 , but significantly lower ALB levels in the third trimester of pregnancy were associated with increased maternal mortality and morbidity 11 .…”

Section: Discussionmentioning

confidence: 99%

“…In pregnancy, serum albumin levels may be decreased in cases of renal insufficiency with proteinuria, preeclampsia, gestational hypertension and gestational edema. Therefore, it may be hypothesized that proteinuria and low serum ALB may lead to low fT4 levels with adverse effects on the course of pregnancy 11,15,[17][18][19][20][21] .…”

Section: Discussionmentioning

confidence: 99%

Associations between the thyroid panel and serum protein concentrations across pregnancy

Lisowska-Myjak

Strawa

Zborowska

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Establishing any characteristic associations between the serum parameters of thyroid function and serum proteins in pregnancy may aid in elucidating the role of the thyroid gland in the regulation of pregnancy-specific metabolic processes and in selecting candidate biomarkers for use in their clinical assessment. Concentrations of thyroid stimulating hormone (TSH), free tri-iodothyronine (fT3) and free thyroxine (fT4), six electrophoretically separated protein fractions (albumin, alpha-1-, alpha2-, beta-1-, beta-2- and gamma-globulins), representative proteins—albumin (ALB), transferrin (TRF), alpha-2-macroglobulin (AMG) and ceruloplasmin (CER) were measured in 136 serum samples from 65 women in their consecutive trimesters of pregnancy. The concentrations of TSH, fT4 and fT3 were significantly correlated (p < 0.05) with the concentrations of the albumin, alpha-2- and beta-1 globulin fractions. Significant correlations (p < 0.05) which were positive between fT4 and ALB and negative between fT4 and TRF were established throughout pregnancy. Significant negative correlations (p < 0.05) were demonstrated for fT3 with alpha-2-globulin, AMG and CER. Changes in the serum concentrations of thyroid hormones seen between the trimesters were found to correlate with the concentrations of high-abundance serum proteins. Opposite directions of correlations between fT4 and ALB and fT4 and TRF observed throughout pregnancy may indicate the shared biological role of these parameters in maintaining maternal homeostasis and they suggest their potential use in the clinic as a simple biomarker panel. A negative correlation of fT3 with CER in the second trimester possibly reflects their involvement in the active regulation of metabolic processes.

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Would thyroid binding globulin compensate for albumin loss during pregnancy?

Cited by 2 publications

References 0 publications

Associations Between The Thyroid Panel and Serum Protein Concentrations Across Pregnancy

Associations Between The Thyroid Panel and Serum Protein Concentrations Across Pregnancy

Associations between the thyroid panel and serum protein concentrations across pregnancy

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