Would you like to purchase a rodent with dermatophytes?

Tekin, Hasan Gökcer; Sigsgaard, V.; Zachariae, Claus; Hare, Rasmus Krøger; Arendrup, Maiken Cavling; Saunte, Ditte Marie Lindhardt

doi:10.1111/myc.12923

Cited by 11 publications

(18 citation statements)

References 27 publications

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“…Nevertheless, some of the animals may have left their homes freely or have left the house with the owners. Therefore, the primary source of infections can be searched in the overpopulation of rodents in urban areas, potentially leading to transmission to domestic animals and further to humans [ 30 ]. One might also consider soil as a possible reservoir of this dermatophyte.…”

Section: Discussionmentioning

confidence: 99%

Laboratory Diagnosis and In Vitro Antifungal Susceptibility of Trichophyton quinckeanum from Human Zoonoses and Cats

et al. 2022

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The “One Health” concept increasingly demonstrates the global spread of pathogenic (also eukaryotic) microorganisms and their zoonotic potential. Dermatophytes can cause superficial mycoses in humans and animals. Furthermore, the number of transmissions from asymptomatic carriers to humans has been on the rise over the last few years. This study was focused on the detailed characterisation of clinical isolates of Trichophyton quinckeanum with epidemiological analyses and characterisation of their in vitro antifungal susceptibility patterns. The isolated dermatophytes were identified with a combination of conventional and molecular methods. In turn, their susceptibility in vitro was tested according to the Clinical and Laboratory Standards Institute (CLSI) M38 ed.3 protocol. A total of 36 strains were isolated, with 21 cases of T. quinckeanum zoonoses resulting from direct contact with symptomatic cats (58.3%). The other 15 strains (41.7%) were isolated simultaneously from healthy cats and their owners. All strains showed high susceptibility to allylamine, pyridinone, and phenyl morpholine derivatives but were resistant to fluconazole and ketoconazole. In conclusion, our study shows the frequency of zoonoses contracted from asymptomatic cats. Moreover, the antifungal susceptibility profiles indicate the serious risk posed to animal owners by resistant strains of T. quinckeanum, which are often responsible for recalcitrant-to-treatment cases.

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Section: Discussionmentioning

confidence: 99%

Laboratory Diagnosis and In Vitro Antifungal Susceptibility of Trichophyton quinckeanum from Human Zoonoses and Cats

et al. 2022

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“…Trichophyton benhamiae is a zoophilic dermatophyte that can cause highly inflammatory tinea in humans and animals [1]. Guinea pigs are the primary carrier, and other small animals are occasionally a source of infection [2]. Due to the increased variety of pets, T. benhamiae infection is rising.…”

Section: Introductionmentioning

confidence: 99%

A case of Tinea Faciei caused by Trichophyton benhamiae: first report in China

Tan

Gao

et al. 2020

BMC Infect Dis

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Background: Trichophyton benhamiae is a zoophilic dermatophyte that can cause tinea in humans and animals. Lesions caused by T. benhamiae tend to be highly inflammatory, and patients are often infected by animals or other patients infected with T. benhamiae. In this paper, we report the first case of tinea faciei caused by T. benhamiae in a Chinese girl who might be transmitted from a fox. Case presentation: A 4-year-old girl from HaiNing city developed an itchy, erythematous, and annular plaque on her right face for the past 2 months. Before the lesion appeared, she was in close contact with the fur of a fox for almost 1 week. Septate hyaline hyphae were detected by direct mycological examination of the scales. Cultures grew on Sabouraud's dextrose agar (SDA) at 26°C for 2 weeks revealed the presence of T. mentagrophytes. A molecular sequencing test confirmed that the isolate was consistent with reference strains to T. benhamiae. Then, the diagnosis of tinea faciei due to T. benhamiae was made. Treatment with terbinafine (oral 125 mg/d) and sertaconazole nitrate cream (topical, twice daily) for 4 weeks was initiated and achieved significant improvement of the skin lesions. Conclusions: This rare dermatophytosis case highlights the importance of ITS sequencing in helping to recognize rare pathogenic fungi that can be easily misdiagnosed with a conventional morphological diagnosis.

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“…3 Carriage studies conducted in Denmark on guinea pigs, hamsters and rabbits in pet stores have shown a 38% positive rate in guinea pigs, 6% in hamsters and 0% in rabbits. 4 In the case presented here, although the dog had no contact with guinea pigs, it did frequently hunt cavies (Microcavia australis), a wild rodent related to guinea pigs, which may have been the source of the contagion. The fungal species presents two phenotypes: one produces white colonies and the other yellow colonies.…”

Section: Discussionmentioning

confidence: 70%

“…Skin infections by T. benhamiae have been associated with inflammation in immunosuppressed children and adults, where it can lead to severe clinical signs with secondary bacterial infections, scarring and kerion celsi 3 . Carriage studies conducted in Denmark on guinea pigs, hamsters and rabbits in pet stores have shown a 38% positive rate in guinea pigs, 6% in hamsters and 0% in rabbits 4 . In the case presented here, although the dog had no contact with guinea pigs, it did frequently hunt cavies ( Microcavia australis ), a wild rodent related to guinea pigs, which may have been the source of the contagion.…”

Section: Discussionmentioning

confidence: 99%