Wound Botulism Resulting from Heroin Abuse: Can You Recognize It?

Abavare, Laura; Abavare, Charles

doi:10.1016/j.jen.2011.01.014

Cited by 6 publications

(1 citation statement)

References 13 publications

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“…Kod intarvenskih aplikacija narkotika aerobno okruženje ne dozvoljava razvoj spora i proizvodnju BoNT (42). Injekcije sa kiselinama dovode do razmekšavanja i nekroze tkiva, smanjuju sadržaj kiseonika u mišićima, a grejanje može izazvati aktiviranje spora koje se mogu nalaziti u heroinu (1,9,22,42,200). Izuzev gastrointestinalnih simptoma, kliničke manifestacije su slične onima kod alimentarnog botulizma.…”

Section: Forme Bolestiunclassified

The investigation of the presence of Clostridium botulinum in honey and honey bee samples

Matović¹

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47%) meda i jednom (1,64%) uzorku medonosnih pčela. Broj spora u pozitivnim uzorcima meda bio je od 20/kg do 204/kg, a u uzorku medonosnih pčela 110/kg.U jednom uzorku meda detektovane su spore B tipa C. botulinum, u jednom uzorku je detektovan E tip, u dva uzorka su detektovane spore istovremeno dva tipa C.botulinum (A, E) i u jednom uzorku istovremeno tri tipa C. botulinum (A, B, E). Spore Clostridium botulinum tipa E dokazane su u jednom uzorku medonosnih pčela. U istim uzorcima meda, odnosno medonosnih pčela, klasičnim kvalitativno-kvantitativnim metodama nije dokazano prisustvo spora Clostridium botulinum.Detekcija spora Clostridium botulinum direktno iz neobrađenih uzoraka meda i medonosnih pčela, bez predobogaćenja, nije moguća primenom metoda PCR i klasičnih metoda mikrobiologije. Klasične metode mikrobiologije, uključujući i metodu SRPS ISO 15213:2011, nisu podesne za detekciju spora Clostridium botulinum u uzorcima meda. Zbog niske osetljivosti navedene metode daju lažno negativne rezultate. U uzorku meda koji je služio kao pozitivna kontrola i koji je prethodno namerno kontaminiran referentnim sojem Clostridium botulinum NCTC 7272, PCR metodom može da se dokaže jedna spora/g meda.U cilju detekcije spora Clostridium botulinum u uzorcima meda i medonosnih pčela primenom metode PCR, za svaki ispitujući uzorak moraju se izvoditi višestruka ponovljanja, ispitivanja jednog istog uzorka, zbog malog broja i/ili neravnomerne raspoređenosti spora u uzorcima. Kjučne reči: Med; Medonosna pčela; Clostridium botulinum; PCR Naučna oblast: Veterinarska medicina Uža naučna oblast: Mikrobiologija namirnica UDK broj: 638:579The investigation of the presence of Clostridium botulinum in honey and honey bee samples

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Section: Forme Bolestiunclassified

The investigation of the presence of Clostridium botulinum in honey and honey bee samples

Matović¹

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Toxic Neuromuscular Transmission Disorders

Howard

2018

Myasthenia Gravis and Related Disorders

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Black Tar Heroin Skin Popping as a Cause of Wound Botulism

Qureshi

Afzal

et al. 2017

Neurocrit Care

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In our patients, BTH injection, involving the action of injecting under the skin acetylated morphine derivatives (mostly 6-monoacetylmorphine and 3-monoacetylmorphine), was associated with the development of botulism. The availability of BTH at the US-Mexican border is not surprising since it is frequently produced in Latin America. Its association with the development of botulism should be recognized early to allow a prompt diagnosis and treatment with the antitoxin. A clinical feature worth noting is the presence of normal pupillary light reflex in nearly half of patients. Therefore, the presence of a normal pupillary response does not exclude the presence of wound botulism.

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Wound Botulism Resulting from Heroin Abuse: Can You Recognize It?

Cited by 6 publications

References 13 publications

The investigation of the presence of Clostridium botulinum in honey and honey bee samples

The investigation of the presence of Clostridium botulinum in honey and honey bee samples

Toxic Neuromuscular Transmission Disorders

Black Tar Heroin Skin Popping as a Cause of Wound Botulism

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