Wound contraction under negative pressure therapy measured with digital image correlation and finite-element analysis in tissue phantoms and wound models

Continuous negative‐pressure wound therapy improves the survival rate of skin grafts and shortens the time required for skin graft survival

“…22 They reported that NPWT increased blood flow levels, rates of formation of the granulation tissue, and survival rates of the random-pattern flap and decreased the bacterial count on the wound in pig models. Subsequently, many in vitro and in vivo studies have shown that NPWT promotes wound healing through the following actions: wound contraction caused by negative pressure, 23,24 generation of various growth factors and cytokines from the wound bed caused by mechanical stress, [25][26][27] improvement of bacterial clearance for wound irrigation, and elimination of excessive exudate. 22,28 The effectiveness of NPWT in skin graft fixation has been demonstrated in several clinical studies.…”