Wound dressings

Lionelli, Gerald T.; Wt, Lawrence

doi:10.1016/s0039-6109(02)00192-5

Cited by 115 publications

(81 citation statements)

References 50 publications

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“…The science behind topical negative pressure dressings is to apply a sub-atmospheric pressure over a wound bed and maintain the negative pressure environment by means of a semi-permeable occlusive coverage.  Traditional frequent wet dressing changes (3)(4) times daily) are protracted and painful 8 .  Interstitial fluid from local wound reduces local blood supply and disturbs wound healing due to collagenase and metalloproteinase enzyme constituents 9 .…”

Section: Resultsmentioning

confidence: 99%

Vacuum Assisted Closure in Chronic Wound Management- A Study of 20 Cases

Gul¹

2018

jmscr

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Section: Resultsmentioning

confidence: 99%

Vacuum Assisted Closure in Chronic Wound Management- A Study of 20 Cases

Gul¹

2018

jmscr

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“…34 However, these products have been designed to ''manage wounds'' and not to prevent scarring. The aggregate body of scientific literature and clinical experience strongly supports a primary role for mechanical forces in fibrogenesis and cutaneous scar formation.…”

Section: Discussionmentioning

confidence: 99%

A Mechanomodulatory Device to Minimize Incisional Scar Formation

Wong

Beasley²,

Zepeda³

et al. 2013

Advances in Wound Care

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Objective: To mechanically control the wound environment and prevent cutaneous scar formation. Approach: We subjected various material substrates to biomechanical testing to investigate their ability to modulate skin behavior. Combinations of elastomeric materials, adhesives, and strain applicators were evaluated to develop topical stress-shielding devices. Noninvasive imaging modalities were utilized to characterize anatomic site-specific differences in skin biomechanical properties in humans. The devices were tested in a validated large animal model of hypertrophic scarring. Phase I within-patient controlled clinical trials were conducted to confirm their safety and efficacy in scar reduction in patients undergoing abdominoplasty surgery. Results: Among the tested materials and device applicators, a polymer device was developed that effectively off-loaded high tension wounds and blocked profibrotic pathways and excess scar formation in red Duroc swine. In humans, different anatomic sites exhibit unique biomechanical properties that may correlate with the propensity to form scars. In the clinical trial, utilization of this device significantly reduced incisional scar formation and improved scar appearance for up to 12 months compared with control incisions that underwent routine postoperative care. Innovation: This is the first device that is able to precisely control the mechanical environment of incisional wounds and has been demonstrated in multiple clinical trials to significantly reduce scar formation after surgery. Conclusion: Mechanomodulatory strategies to control the incisional wound environment can significantly reduce pathologic scarring and fibrosis after surgery. INTRODUCTIONWound healing proceeds through overlapping stages of inflammation, proliferation, and remodeling.1 All wounds heal with some degree of scar formation, but the mechanisms that govern whether the result will be a fine thin scar, a prominent hypertrophic scar, or a tumor-like keloid remain unclear.2,3 It is estimated that more than 230 million major surgical procedures are performed around the world each year, all of which result in cutaneous wounds which heal with scars. 4 In addition, fibrotic complications after injury can cause considerable dysfunction and disfigurement, costing more than $4 billion yearly in healthcare costs in the United States alone.5 Modern multimodality regimens have produced inconsistent outcomes, and recombinant cytokinebased strategies have failed to prevent scar formation in phase III clinical trials (www.renovo.com). 6 The current challenge for researchers and health care providers is to develop highly effective approaches that combat this significant biomedical problem.The role of mechanical force in wound healing was observed by anatomists and surgeons more than a century ago.7 Subsequent clinical observations and reports have substantiated the importance of tension in scar formation after injury. For example, sternotomy wounds develop greater fibrosis in the lower half of the incision that is subj...

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“…Los apósitos o wound dressing son elementos que ayudan a evitar la infección y mantener un entorno apropiado que permita la correcta cicatrización de la herida [1], para ello deben contar con ciertas características esenciales como la capacidad hemostática o antihemorrágica, poder antibacteriano, absorción de excesos de líquidos exudados como fluidos de la herida o pus, transmisión apropiada entre agua y vapor, capacidad de ajustarse al contorno de la herida, adhesión funcional al tejido sano, no al herido, indoloro para el paciente y finalmente que pueda removerse con facilidad [2][3][4][5]. Lograr estas propiedades es posible con procesos tecnológicos como el electrospinning, proceso utilizado para la formación de fibras a escala nano y micrométrica.…”

Section: Introductionunclassified

Usos de la Sangre de drago (Croton Lechleri Müll) en apósitos para heridas crónicas obtenidos mediante la técnica de Electrospinning

Melo

Núñez

Vizuete

et al. 2018

CCTESPE

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El presente estudio tiene como principal objetivo dar uso a un material ancestral poco usado como es la sangre de drago (Croton Lechleri Müll), tecnificándolo por primera vez a través de un proceso tecnológico como el electrospinning para la obtención de fibras y partículas a escalas nano y micrométricas proyectándolas a posteriores aplicaciones en apósitos bioactivos para heridas crónicas, que aprovechen las propiedades curativas (antibacteriales, cicatrizantes, antibióticas, antioxidantes, etc.) de la savia y las características morfológicas de las estructuras propias de la técnica. Se consideraron varias concentraciones de sangre de drago en diferentes soluciones poliméricas base, siendo principal la solución de fibroína de seda aprovechando las propiedades de la seda en aplicaciones de ingeniería de tejidos desarrollando de 4 alternativas de apósito analizadas mediante microscopia electrónica de barrido (SEM) y finalmente aproximando cual sería la mejor para la aplicación antes definida.

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Wound dressings

Cited by 115 publications

References 50 publications

Vacuum Assisted Closure in Chronic Wound Management- A Study of 20 Cases

Vacuum Assisted Closure in Chronic Wound Management- A Study of 20 Cases

A Mechanomodulatory Device to Minimize Incisional Scar Formation

Usos de la Sangre de drago (Croton Lechleri Müll) en apósitos para heridas crónicas obtenidos mediante la técnica de Electrospinning

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