Wound Dressings: An Advanced Multifunctional Hydrogel‐Based Dressing for Wound Monitoring and Drug Delivery (Adv. Healthcare Mater. 19/2017)

Mirani, Bahram; Pagan, Erik; Currie, Barbara; Siddiqui, Mohammad Ali; Hosseinzadeh, Reihaneh; Mostafalu, Pooria; Zhang, Yu Shrike; Ghahary, Aziz; Akbari, Mohsen

doi:10.1002/adhm.201770103

Cited by 5 publications

(3 citation statements)

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“…Achieving stable, localized drug delivery requires a multifaceted material design strategy to ensure prolonged adhesion and desired drug release kinetics. ,,− From the perspective of adhesion, the design of a tough matrix with tissue-bonding surface groups forms the basis for realizing a robust, long-term residence. From the perspective of drug delivery, the mesh size of the matrix, drug-polymer interactions, and matrix degradation kinetics are key factors for determining the drug delivery rate .…”

Section: Nontraditional Applications Of Bioadhesivesmentioning

confidence: 99%

Bioadhesive Technology Platforms

Wu,

Zhao

2023

Chem. Rev.

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Bioadhesives have emerged as transformative and versatile tools in healthcare, offering the ability to attach tissues with ease and minimal damage. These materials present numerous opportunities for tissue repair and biomedical device integration, creating a broad landscape of applications that have captivated clinical and scientific interest alike. However, fully unlocking their potential requires multifaceted design strategies involving optimal adhesion, suitable biological interactions, and efficient signal communication. In this Review, we delve into these pivotal aspects of bioadhesive design, highlight the latest advances in their biomedical applications, and identify potential opportunities that lie ahead for bioadhesives as multifunctional technology platforms.

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Section: Nontraditional Applications Of Bioadhesivesmentioning

confidence: 99%

Bioadhesive Technology Platforms

Wu,

Zhao

2023

Chem. Rev.

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“…[1,2] The traditional wound dressings have many problems such as easy adherence to the wound area to cause collateral damage, being too dry to slow down the speed of wound healing, and low antibacterial capability to lead to infection. [3][4][5][6] An ideal wound dressing should have the following characteristics: 1) fit closely to the wound but without strong adhesion or too easy to be removed, 2) good moisturization and water keeping ability, 3) good air permeability, and 4) efficient antibacteria capability. [7][8][9][10] To realize these requirements, the simple wound treatment using gel materials blended with specific medicine or solid cover coated with antibacteria layer are thus inefficient.…”

Section: Introductionmentioning

confidence: 99%

Silk Fibroin‐Based Nanoparticles Blended Fluoridated Hydrogel with Photodynamic Antibacterial for Infected Wound Healing

Liu,

Zhang

et al. 2024

Advanced Therapeutics

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Traditional approaches for treating wound infections often involve the use of chitosan or hyaluronic acid as carriers for antibacterial agents. In contrast, an innovative method is devised for wound infection management that synergizes photodynamic therapy (PDT) with novel functional matrix materials. This new strategy offers multiple benefits, such as reduced secondary damage to the wound area, a multifaceted antibacterial mechanism, and enhanced moisturization and biocompatibility. The method employs a novel organic semiconductor nanoparticle (OSN) capable of mediating PDT, which is integrated with silk fibroin (SF), perfluorosulfonic acid (PFSA), and agar. Silk fibroin is demonstrated to effectively induce macrophage aggregation, while PDT can further activate these immune cells. The inclusion of PFSA bestows the hydrogel with moisturizing and porous characteristics. Both in vivo and in vitro antibacterial assays confirm the efficacy of PDT in eliminating bacteria, and mouse wound infection model studies show that the hydrogels significantly enhance wound healing and hair follicle regeneration. This novel hydrogel dressing holds promise as an advanced wound care solution, with substantial potential for promoting hair follicle regeneration and providing effective sterilization.

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“…[4][5][6] To deal with these problems, a huge amount of efforts has been made, for example, some reports utilized protein [7,8] and antibacterial agents [9][10][11] to heal the wounds; however, these problems are still a challenge to medicine. [12,13] www.advancedsciencenews.com www.mcp-journal.de…”

Section: Introductionmentioning

confidence: 99%

Covalent Chitosan‐Cellulose Hydrogels via Schiff‐Base Reaction Containing Macromolecular Microgels for pH‐Sensitive Drug Delivery and Wound Dressing

Chen

et al. 2019

Macro Chemistry & Physics

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Wound dressings with pH‐sensitive properties, stable mechanical performance, and antibacterial properties have great potential for clinical applications. Herein, drug‐loaded microgels via Schiff‐base reaction between carboxymethyl chitosan and oxidized carboxymethyl cellulose are fabricated. Then they are embedded in hydrogels to form a hydrogel‐microgels composite (Gel/MGs). The gelation time, morphologies, swelling ratio, weight loss ratio, mechanical properties, pH‐sensitive drug release profiles, and antibacterial activities are examined. Adding microgels endows the hydrogels with more stable properties, enhanced mechanical performance, and drug release sensitivity to both acid and alkali in vitro. Gel/MGs dressings show a steady mass after 6 h and even maintain its 95.4% initial mass after 14 days in pH 7.4. In pH 9.5, Gel/MGs dressings also show a higher cumulative release of silver sulfadiazine than that in pH 7.4 and pH 5.5. Gel/MGs/AgSD dressings demonstrate desirable antibacterial properties, which may ensure their potential application in wound dressing.

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Wound Dressings: An Advanced Multifunctional Hydrogel‐Based Dressing for Wound Monitoring and Drug Delivery (Adv. Healthcare Mater. 19/2017)

Cited by 5 publications

References 0 publications

Bioadhesive Technology Platforms

Bioadhesive Technology Platforms

Silk Fibroin‐Based Nanoparticles Blended Fluoridated Hydrogel with Photodynamic Antibacterial for Infected Wound Healing

Covalent Chitosan‐Cellulose Hydrogels via Schiff‐Base Reaction Containing Macromolecular Microgels for pH‐Sensitive Drug Delivery and Wound Dressing

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