Wound healing.

Schilling, John A.

doi:10.1152/physrev.1968.48.2.374

Cited by 90 publications

(21 citation statements)

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“…However, the exact mechanism by which jaundice interferes with this process is not known, nor whether other parts of the healing mechanism are affected. In particular, before collagen fibres are deposited in the ground substance the early stage of healing in man and animals is characterized by a massive infiltration and proliferation of reticulo-endothelial cells and fibroblasts into the wound (Schilling, 1968;Alexander, Bossert, McClellan, and Altemeier, 1971). The experiments described in the present paper were carried out to see whether obstructive jaundice interferes with the migratory activity of these cells and prevents their appearance in foreign-body granulomata.…”

Section: Discussionmentioning

confidence: 99%

The effect of obstructive jaundice on the migration of reticulo-endothelial cells and fibroblasts into early experimental granulomata

Lee

1972

Journal of British Surgery

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Clinical and experimental evidence indicates that obstructive jaundice inhibits the healing of wounds. Experiments in the rat designed to investigate the migration of reticulo‐endothelial and fibroblasts into experimental granulomata are described. Standard preparations of obstructive jaundice and controls were devised using Wistar rats. The effects of bile‐duct obstruction and sham ligation are described. In another group of animals which was similarly prepared granuloma‐pouch experiments were carried out by burying sterile cotton‐wool pledgets of a known weight. These peledgets were removed from the jaundiced and control animals on the third, fifth, seventh, and ninth days after implantation, dried to remove the fluid component of the inflammatory process, and weighed on a microbalance. The weights were compared and it was found that a significant inhibition of weight increase occurred in the jaundiced animals during the first week, suggesting a delay in the migratory activity of reticuloendothelial cells and fibroblasts.

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Section: Discussionmentioning

confidence: 99%

The effect of obstructive jaundice on the migration of reticulo-endothelial cells and fibroblasts into early experimental granulomata

Lee

1972

Journal of British Surgery

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“…In general, material necessary for wound healing is derived from the serum [16], After intraperitoneal injection, the major portion of radioac- Fig. 3.…”

Section: / Morphological Changesmentioning

confidence: 99%

Reparative Processes in Heart Muscle Following Myocardial Infarction

Rj¹

1971

Cardiology

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“…Wound has been defined as disruption of anatomic or functional continuity of living tissues 1 . Wound repair may be described as an effort to restore normal function & structural integrity of the injured tissue 2 .…”

Section: Introductionmentioning

confidence: 99%