Wound healing action of topical nitric oxide releasing poly(acrylic acid)/pluronic F127 hydrogel membranes

Militão, Lucas; Champeau, Mathilde; Jara, Carlos Poblete; Oliveira, Marcelo Ganzarolli de; Araújo, Eliana P.

doi:10.19146/pibic-2016-51722

Cited by 1 publication

(1 citation statement)

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“…Hydrogel is commonly employed as a wound dressing due to its ability to maintain moisture in the wound area, creating ideal circumstances for effective wound healing [ 1 ]. Furthermore, GSNO exhibits high solubility in water, making it well-suited for topical and targeted administration in hydrophilic matrices [ 6 ]. Nevertheless, hydrogels have inadequate mechanical characteristics and experience deformation when subjected to external pressures.…”

Section: Introductionmentioning

confidence: 99%

The Formulation and Characterization of Wound Dressing Releasing S-Nitrosoglutathione from Polyvinyl Alcohol/Borax Reinforced Carboxymethyl Chitosan Self-Healing Hydrogel

Palungan,

Luthfiyah,

Mustopa

et al. 2024

Pharmaceutics

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Self-healing hydrogels often lack mechanical properties, limiting their wound-dressing applications. This study introduced S-Nitrosoglutathione (GSNO) to self-healing hydrogel-based wound dressings. Self-healing hydrogel mechanical properties were improved via polymer blends. Applying this hydrogel to the wound site allows it to self-heal and reattach after mechanical damage. This work evaluated polyvinyl alcohol (PVA)-based self-healing hydrogels with borax as a crosslinking agent and carboxymethyl chitosan as a mechanical property enhancer. Three formulations (F1, F4, and F7) developed self-healing hydrogels. These formulations had borax concentrations of 0.8%, 1.2%, and 1.6%. An FTIR study shows that borate ester crosslinking and hydrogen bonding between polymers generate a self-healing hydrogel. F4 has a highly uniform and regular pore structure, as shown by the scanning electron microscope image. F1 exhibited faster self-healing, taking 13.95 ± 1.45 min compared to other formulations. All preparations had pH values close to neutrality, making them suitable wound dressings. Formula F7 has a high drug content (97.34 ± 1.21%). Good mechanical qualities included high tensile stress–strain intensity and Young’s modulus. After 28 h of storage at −20 °C, 5 °C, and 25 °C, the self-healing hydrogel’s drug content dropped significantly. The Korsmeyer–Peppas release model showed that the release profile of GSNO followed Fickian diffusion. Thus, varying the concentration of crosslinking agent and adding a polymer affects self-healing hydrogels’ physicochemical properties.

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Section: Introductionmentioning

confidence: 99%