Wound-healing activity of Algerian <i>Lavandula stoechas</i> and <i>Mentha pulegium</i> extracts: from traditional use to scientific validation

Baali, Faiza; Boumerfeg, Sabah; Boudjelal, Amel; Denaro, Marcella; Ginestra, Giovanna; Baghiani, Abderrahmane; Righi, Nadjat; Deghima, Amirouche; Benbacha, Faycel; Smeriglio, Antonella; Trombetta, Domenico

doi:10.1080/11263504.2020.1869117

Cited by 11 publications

(13 citation statements)

References 41 publications

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“…These results may be due to differences in cell wall composition or genes responsible for extract resistance. According to a recent study [ 47 ], M. pulegium extract exhibited antibacterial potential against S. aureus only, and therefore it was applied for wound healing. Previous reports have indicated the antimicrobial activity of M. pulegium extract towards many bacteria (including five gram-positive and five gram-negative types) and fungi including six fungal species [ 7 ].…”

Section: Resultsmentioning

confidence: 99%

“…The current study suggested that the main contributors to the antioxidant potential are associated with phenolic and flavonoid contents. Strong antioxidant activity of M. pulegium extract has been documented via numerous techniques including DPPH, trolox equivalent antioxidant capacity, ferric reducing antioxidant power, and oxygen radical absorbance capacity [ 47 ]. Many studies have reported relationships between phenolic content and antioxidative activity in plants [ 10 , 11 ].…”

Section: Resultsmentioning

confidence: 99%

“…This was noted in the GC-MS analysis, and it was previously demonstrated that pulegone can inhibit inflammation mechanisms [ 51 , 52 ]. Recently, Baali et al [ 47 ] mentioned the promising activity of M. pulegium extract as a wound healing agent and documented a scientific rationale that confirmed the traditional application of this plant.…”

Section: Resultsmentioning

confidence: 99%

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Molecular Interaction Studies and Phytochemical Characterization of Mentha pulegium L. Constituents with Multiple Biological Utilities as Antioxidant, Antimicrobial, Anticancer and Anti-Hemolytic Agents

et al. 2022

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Multiple biological functions of Mentha pulegium extract were evaluated in the current work. Phytochemical components of the M. pulegium extract were detected by Gas Chromatography-Mass Spectrometry (GC-MS) and High-performance liquid chromatography (HPLC). Moreover, M. pulegium extract was estimated for antioxidant potential by 2,2-Diphenyl-1-picryl-hydrazyl-hydrate (DPPH) free radical scavenging, antimicrobial activity by well diffusion, and anticoagulant activity via prothrombin time (PT) and activated partial thromboplastin time (APTT). GC-MS analysis detected compounds including cholesterol margarate, stigmast-5-en-3-ol, 19-nor-4-androstenediol, androstan-17-one, pulegone-1,2-epoxide, isochiapin B, dotriacontane, hexadecanoic acid and neophytadiene. Chrysoeriol (15.36 µg/mL) was followed by kaempferol (11.14 µg/mL) and 7-OH flavone (10.14 µg/mL), catechin (4.11 µg/mL), hisperdin (3.05 µg/mL), and luteolin (2.36 µg/mL) were detected by HPLC as flavonoids, in addition to ferulic (13.19 µg/mL), cinnamic (12.69 µg/mL), caffeic (11.45 µg/mL), pyrogallol (9.36 µg/mL), p-coumaric (5.06 µg/mL) and salicylic (4.17 µg/mL) as phenolics. Antioxidant activity was detected with IC50 18 µg/mL, hemolysis inhibition was recorded as 79.8% at 1000 μg/mL, and PT and APTT were at 21.5 s and 49.5 s, respectively, at 50 μg/mL of M. pulegium extract. The acute toxicity of M. pulegium extract was recorded against PC3 (IC50 97.99 µg/mL) and MCF7 (IC50 80.21 µg/mL). Antimicrobial activity of M. pulegium extract was documented against Bacillus subtilis, Escherichia coli, Pseudomonasaureus, Candida albicans, Pseudomonas aeruginosa, but not against black fungus Mucor circinelloides. Molecular docking was applied using MOE (Molecular Operating Environment) to explain the biological activity of neophytadiene, luteolin, chrysoeriol and kaempferol. These compounds could be suitable for the development of novel pharmacological agents for treatment of cancer and bacterial infections.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Molecular Interaction Studies and Phytochemical Characterization of Mentha pulegium L. Constituents with Multiple Biological Utilities as Antioxidant, Antimicrobial, Anticancer and Anti-Hemolytic Agents

et al. 2022

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“…The proanthocyanidin content was evaluated according to Baali et al [ 80 ]. Briefly, 2.0 mL of sample solution diluted with 0.05 M H 2 SO 4 (0.75 mg/mL for PCC; 5 mg/mL for PCF, PCC, ADF and ADC; 10 mg/mL for RAC and CIF; 20 mg/mL for RAF), was loaded onto a Sep-Pak C18 cartridge (Waters, Milan, Italy) preconditioned with 5 mM H 2 SO 4 (2.0 mL), and purged with air.…”

Section: Methodsmentioning

confidence: 99%

Characterization of Ingredients Incorporated in the Traditional Mixed-Salad of the Capuchin Monks

Cornara

Ambu

Alberto

et al. 2022

Plants

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Recipes on the composition of the “salad of the monks” (Capuchin monks) have been reported in Italy since the 17th century. Different wild edible plants were highly regarded as an important ingredient of this mixed salad. Among these, some species played a key role for both their taste and nutritional properties: Plantago coronopus L. (PC), Rumex acetosa L., Cichorium intybus L., and Artemisia dracunculus L. In the present study, the micromorphological and phytochemical features as well as the antioxidant and anti-inflammatory properties of extracts of these fresh and blanched leaves, were investigated. The extracts obtained by blanched leaves, according to the traditionally used cooking method, showed the highest content of bioactive compounds (total phenols 1202.31–10,751.88 mg GAE/100 g DW; flavonoids 2921.38–61,141.83 mg QE/100 g DW; flavanols 17.47–685.52 mg CE/100 g DW; proanthocyanidins 2.83–16.33 mg CyE/100 g DW; total chlorophyll 0.84–1.09 mg/g FW; carbohydrates 0.14–1.92 g/100 g FW) and possess the most marked antioxidant (IC50 0.30–425.20 µg/mL) and anti-inflammatory activity (IC50 240.20–970.02 µg/mL). Considering this, our results indicate that increased consumption of the investigated plants, in particular of PC, raw or cooked briefly, could provide a healthy food source in the modern diet by the recovery and enhancement of ancient ingredients.

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“…Lavender oil, in particular, has a long history of use in wound repair. It has been stated that lavender EOs have a wide range of pharmacological properties that could be beneficial in the wound healing process [46][47][48]. Antimicrobial agents play a vital part in tissue regeneration.…”

Section: A1 A2mentioning

confidence: 99%

Topical Emulsion Containing Lavandula stoechas Essential Oil as a Therapeutic Agent for Cutaneous Wound Healing

Boukhatem

Chader²,

Houche

et al. 2021

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Background and objectives: The present research was designed to evaluate the chemical composition of Lavandula stoechas essential oil (EOLS) as well as the in vivo wound-healing property. The chemical composition of EOLS was identified by gas chromatography mass spectrometry. Nineteen compounds of EOLS were reported. Linalool was identified as the major chemical compound (24.87%), followed by linalyl acetate (19.10%). EOLS showed a high content of oxygenated compounds (63.54%). In vivo wound healing activity of the topical cream prepared from EOLS (0.5% w/w) was assessed using a circular excision wound model. The wound area (mm2) in all animal groups was estimated and measured on day 0, 4, 8, 11, and 16. Results: The EOLS formulation cream (0.5% v/w) showed the highest effect on wound models when compared to reference Madecassol® (Asiaticoside). On days 4, 11, and 16, wound contractions were 26.4%, 78%, and 96.3% for the EOLS-treated group, and 8.5%, 64.1%, and 86.1% for the vehicle cream-treated group. Animals treated with EOLS cream showed a significant decrease in the epithelization period, wound area, and scar thickness, whereas the rate of wound contraction significantly increased. This is the first such report to be published. Histological analyses were also consistent with the results of the excision experimental method. Treatment with EOLS cream formulation resulted in decreased inflammation and an increased rate of tissue perfusion and proliferation as well as remodeling, along with re-epithelization. Conclusions: Our results support the use of EOLS in the development of pharmaceuticals for the management of wounds, and/or inflammatory-related diseases. Additional studies are needed to elucidate and explain the exact mechanism of its pharmacological activity.

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Wound-healing activity of Algerian Lavandula stoechas and Mentha pulegium extracts: from traditional use to scientific validation

Cited by 11 publications

References 41 publications

Molecular Interaction Studies and Phytochemical Characterization of Mentha pulegium L. Constituents with Multiple Biological Utilities as Antioxidant, Antimicrobial, Anticancer and Anti-Hemolytic Agents

Molecular Interaction Studies and Phytochemical Characterization of Mentha pulegium L. Constituents with Multiple Biological Utilities as Antioxidant, Antimicrobial, Anticancer and Anti-Hemolytic Agents

Characterization of Ingredients Incorporated in the Traditional Mixed-Salad of the Capuchin Monks

Topical Emulsion Containing Lavandula stoechas Essential Oil as a Therapeutic Agent for Cutaneous Wound Healing

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