Wound healing activity of Sida cordifolia Linn. in rats

Pawar, Rajesh Singh; Chaurasiya, P. K.; Rajak, Harish; Singour, Pradeep Kumar; Toppo, Fedelic Ashish; Jain, Ankit

doi:10.4103/0253-7613.117759

Cited by 56 publications

(39 citation statements)

References 11 publications

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“…The main function of fibroblasts is the maintenance of the structural integrity of connective tissues, starting the synthesis and secretion of ECM components such as glycosaminoglycans and collagen fibers types I and III [10,11]. Fibroblasts are directly involved in the wound healing process being the principal cell type that establishes the collagen matrix at the wound site [64].…”

Section: Discussionmentioning

confidence: 99%

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2015

JPP

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Abstract:Objectives: Burns are shown as a clinical problem for their severity and multiple complications due to the time required to heal. Therapies that improve their healing are of great importance, especially for being minimally invasive, of low cost and best performance, all related to the speed and quality of healing. This study investigated the effects of the magnetic electro stimulator Haihuá CD9 isolated or in association with Aloe vera in rats skin burns. Methods: Experimental groups (n = 30/group) were: (C) Carbopol gel; (F) A. vera/Carbopol gel; (H) Haihuá+Carbopol gel; (H+F) Haihuá+A. vera/Carbopol gel. Samples were collected on the 7th, 14th, and 21st experimental days for structural and morphometric analysis, hydroxyproline and glycosaminoglycans quantification, zymography for MMP-2 and MMP-9 and Western Blotting for TGF-β1, VEGF, Collagen I and III. Key findings: The expression of TGF-β1 in H+F was increased on the 7th day and of MMP-9 on the 7th and 14th days. The expression of VEGF increased in the first experimental periods and decreased in the last for the treated groups. There was an increase in the fibroblasts and birefringent collagen fibers in groups treated with Haihuá isolated or in association with A. vera in all periods. The quantification of collagen I increased, while collagen III decreased in H+F. The higher amount of GAGs and MMP-2 active isoform was detected in H and H+F during all periods. Conclusions: Considering the results of the present study, electromagnetic stimulation in association with the A. vera extract promoted an increase in the number of fibroblasts, GAGs content, MMP-2 activity, the deposition and organization of collagen fibers, favoring the repair of injuries to second degree burns, and may also present therapeutic potential in this injury type.

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Section: Discussionmentioning

confidence: 99%

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2015

JPP

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“…The continuous threads on both wound edges were tightened for good closure of the wound. After stitching, wound was left undressed then ointment base, MEZX ointment and standard ointment were applied daily until 10 days; when wounds were cured thoroughly the sutures were removed on the day 10 and tensile strength of cured wound skin was measured using tensiometer 22 .…”

Section: Incision Wound Modelmentioning

confidence: 99%

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2017

IJPSR

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Aim:The present study provides a scientific evaluation for the wound healing activity of methanolic extract of Ziziphus xylopyrus (Retz) Willd leaves (MEZX). Methods: Incision and excision wound models were used to evaluate the wound healing activity of MEZX on Wistar rats. In each model, animals were divided into four groups of 6 animals each. In both model, Group I was assigned as control (ointment base). Group II and III were treated with 5%w/w and 10% w/w MEZX topical ointment respectively. Group IV was treated with standard nitrofurazone ointment (0.2% w/w). The parameters recorded were percentage of wound contraction, epithelialisation period and tensile strength. Results: It was noted that the effect produced by MEZX ointment showed significant (P < 0.001) healing in all wound models when compared with the control group. All parameters such as wound contraction, epithelialisation period and tensile strength showed significant (P < 0.001) changes when compared with the control. MEZX stimulates wound contraction, decreases epithelialisation period and increases tensile strength. Conclusion: This study suggests that MEZX possesses wound healing activity against Incision and excision wound.

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“…The basic principle in wound healing is to minimize tissue damage, provide enough nourishment, bleeding, oxygenation of tissue, and prevent scar formation (Olczyk, Mencner, & Komosinska‐Vassev, ). The wound repair process consists of three main processes: inflammatory phase (consisting the establishment of homeostasis and inflammation), proliferative phase (consisting of granulation, contraction, and epithelialization), and remodeling phase (Pawar et al, ). These processes requires a complex interaction of cells (platelets, neutrophils, monocytes/macrophages, fibroblasts, endothelial cells, and keratinocytes cells), and of extracellular matrix components (ECM), integrins, growth factors, and matrix metalloproteinases (MMPs) (Olczyk et al, ).…”

Section: Introductionmentioning

confidence: 99%

Effect of Horse-chestnut seed extract on matrix metalloproteinase-1 and -9 during diabetic wound healing

et al. 2019

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The effects of aqueous‐ethanol extract of Horse chestnut (HCE) on MMP‐1 and MMP‐9 expressions during cutaneous wound healing in diabetic rats were investigated in this study. The expressions of MMP‐1 and MMP‐9, wound closure, myeloperoxidase (MPO) activity, hydroxyproline, and malondialdehyde (MDA) levels in wound tissue were measured. Quercetin glucuronide in HCE was identified as main compound using a LC‐MS/MS. The hydroxyproline level was significantly increased in the treated group versus control after the 3rd and 7th days (p < 0.05). The MDA level and MPO activity were significantly lower in the treatment group (p < 0.05). MMP‐1 gene expression level in treated rats was increased in the 7th day while it was reduced in 14th day. MMP‐9 gene expression level in treated rats was decreased in 7th, and 14th days compared to control (p < 0.05). These results show that HCE accelerated the cutaneous wound‐healing process in diabetic rats via MMP‐1 and MMP‐9 regulation. Practical applications The main function of MMPs is to degrade and deposite the various components of the extracellular matrix. Also, they participate physiological processes such as inflammation, angiogenesis, and tissue remodeling. Horse chestnut seeds (HC) are known to be rich in saponins and flavonoids. HC are used for the treatment of abdominal pain, stomach ache, cold, hemorrhoids, arterial stiffness, rheumatism, oedema, diarrhea, chronic venous insufficiency and also as an antihemorrhagic and antipyretic in traditional medicine. It has been shown that HC has anti‐inflammatory, antioedema, vessel protective, and free radical scavenging properties. This study indicates that HCE could be an effective agent for wound healing in diabetic wound model via its ability to suppress the MMP‐9 gene expression and regulates MMP‐1 gene expression besides its antioxidative, anti‐inflammatory effects.

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Wound healing activity of Sida cordifolia Linn. in rats

Cited by 56 publications

References 11 publications

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Effect of Horse-chestnut seed extract on matrix metalloproteinase-1 and -9 during diabetic wound healing

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