Wound healing activity of terpinolene and α-phellandrene by attenuating inflammation and oxidative stress in vitro

Scherer, Marcella Malavazi de Christo; Marques, Franciane Martins; Figueira, Mariana Moreira; Peisino, Maria Carolina Oliveira; Schmitt, Elisângela Flávia Pimentel; Kondratyuk, Tamara P.; Endringer, Denise Coutinho; Scherer, Rodrigo; Fronza, Márcio

doi:10.1016/j.jtv.2019.02.003

Cited by 87 publications

(55 citation statements)

References 39 publications

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“…For instance, thymol is reported to protect the heart against isoproterenol-induced myocardial infarction and cardiac hypertrophy via anti-apoptotic effect [43]. In addition, elemol, β-elemene, terpinolene, βcaryophyllene, and thymol, which represented more than 33% of the total essential oil, are known to suppress several pro-inflammatory cytokines, including TNF-α, IL-1β, and IL-6 [44][45][46][47][48]. In addition, production of pro-inflammatory cytokines IL-4, IL-8, and IL-12 was inhibited by elemol, thymol, and β-elemene, respectively [49][50][51].…”

Section: Discussionmentioning

confidence: 99%

Cymbopogon Proximus Essential Oil Protects Rats against Isoproterenol-Induced Cardiac Hypertrophy and Fibrosis

et al. 2020

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Cymbopogon proximus (Halfabar), a wild plant that is usually used in folk medicine due to its diuretic and antispasmodic effects, was shown to exhibit several cardiovascular protective actions such as antidiabetic, antihypertensive, antioxidant, and antinflammatory effects. However, no reports are available regarding the investigation of the role of Cymbopogon proximus essential oil on cardiac hypertrophy. Therefore, the goals of the present study were to find whether Cymbopogon proximus could alleviate isoproterenol induced‐cardiac hypertrophy and to determine the underlying molecular mechanisms. For this purpose, male albino rats were treated daily with either Cymbopogon proximus essential oil (800 μl/kg/day, ip), isoproterenol (5 mg/kg/day, ip), or the combination of both. Oil administration was started four days prior to isoproterenol administration and continued concurrently thereafter for another three days. All animal groups were euthanized 24 hours after the last dose of treatment. Thereafter, the hearts were harvested and heart weight to body weight (HW:BW) ratios were measured and sections of hearts were stained with Masson's trichrome and H&E to assess cardiac fibrosis and morphology. Our results showed that isoproterenol alone resulted in a significant increase in HW:BW ratio and marked myocardial fibrosis in treated rats. On the other hand, treatment with Cymbopogon proximus essential oil significantly reduced the isoproterenol‐mediated increase in HW:BW ratio by 55%. However, oil treatment did not affect isoproterenol mediated‐increase in myocardial fibrosis. Conclusion Cymbopogon proximus essential oil partly protects against isoproterenol‐induced cardiac hypertrophy with no effect on cardiac fibrosis. These findings provide support for the promising therapeutic effects of Cymbopogon proximus on cardiac diseases. This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.

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Section: Discussionmentioning

confidence: 99%

Cymbopogon Proximus Essential Oil Protects Rats against Isoproterenol-Induced Cardiac Hypertrophy and Fibrosis

et al. 2020

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“…Therefore, from the findings of both GC and LC chromatographic analyses, the identified notable compounds were highly possible for the antioxidant activity. Some aroma compounds such as limonene, furfural, α-pinene, terpinen-4-ol, and γ-terpinene and polar compounds like dicaffeoylquinic acid, quercetagetin, and 2 -O-acetylrutin have been reported to possess potent antioxidant activity [22][23][24][25][26][27][28][29][30][31][32].…”

Section: Discussionmentioning

confidence: 99%

Untargeted and Targeted Metabolomic Profiling of Australian Indigenous Fruits

et al. 2020

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Selected Australian native fruits such as Davidson's plum, finger lime and native pepperberry have been reported to demonstrate potent antioxidant activity. However, comprehensive metabolite profiling of these fruits is limited, therefore the compounds responsible are unknown, and further, the compounds of nutritional value in these native fruits are yet to be described. In this study, untargeted and targeted metabolomics were conducted using the three fruits, together with assays to determine their antioxidant activities. The results demonstrate that targeted free and hydrolysed protein amino acids exhibited high amounts of essential amino acids. Similarly, important minerals like potassium were detected in the fruit samples. In antioxidant activity, Davidson's plum reported the highest activity in ferric reducing power (FRAP), finger lime in antioxidant capacity (ABTS), and native pepperberry in free radical scavenging (DPPH) and phosphomolybdenum assay. The compounds responsible for the antioxidant activity were tentatively identified using untargeted GC×GC-TOFMS and UHPLC-QqQ-TOF-MS/MS metabolomics. A clear discrimination into three clusters of fruits was observed using principal component analysis (PCA) and partial least squares (PLS) analysis. The correlation study identified a number of compounds that provide the antioxidant activities. GC×GC-TOFMS detected potent aroma compounds of limonene, furfural, and 1-R-α-pinene. Based on the untargeted and targeted metabolomics, and antioxidant assays, the nutritional potential of these Australian bush fruits is considerable and supports these indigenous fruits in the nutraceutical industry as well as functional ingredients for the food industry, with such outcomes benefiting Indigenous Australian communities.

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“…For example, when the RAW 264.7 cells, murine macrophages, were stimulated by lipopolysaccharide (LPS), the levels of pro-inflammatory mediators were significantly increased [125]. Pre-treatment with several terpenes including d-limonene, terpinolene, linalool, α-terpineol, α-phellandrene, and γ-terpinene, reduced LPS-induced pro-inflammatory mediator production in in vitro cultured RAW 264.7 cells [46,50,51,53,68,71]. In cultured chondrocytes, an in vitro model of arthritis-related inflammation [126], d-limonene and myrcene decreased NO and iNOS levels [49], while bornyl acetate elevated the expression of IL-11, which inhibits IL-1β-mediated up-regulation of IL-6, IL-8, matrix metallopeptidases (MMP)-1, and MMP-13 [77].…”

Section: Regulation Of Pro-inflammatory Mediatorsmentioning

confidence: 99%

“…Furthermore, myrcene treatment dramatically reduced the phosphorylation of various MAPK-related signaling molecules, suggesting its potential application in the skincare industry owing to its protective effect on photoaging. Terpinolene and α-phellandrene have also been shown to attenuate inflammation and oxidative stress in vitro by significantly inhibiting NO and superoxide production in a macrophage cell-culture-based assay [53]. In another in vitro experiment to assess antioxidant capacities, four monoterpenes, linalool, linalyl acetate, α-terpinene, and γ-terpinene, were found to scavenge peroxyl radicals, strong oxidant nitrogen radicals, weak oxidant nitrogen radicals, and lipidic peroxyl radicals, as well as to chelate oxidant metal ions [108].…”

Section: Function Of Terpene Compounds Against Oxidative Stressmentioning

confidence: 99%

“…Treatment with α-phellandrene-induced ROS production and cytochrome c release from mitochondria, subsequently triggering apoptosis of the tumor cells, thus suggesting its potential as an anti-tumor agent. However, interestingly, an opposite activity of α-phellandrene on wound healing has recently been reported, as it was shown to attenuate inflammation and oxidative stress in vitro [53].…”

Section: Function Of Terpene Compounds Against Oxidative Stressmentioning

confidence: 99%

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Therapeutic Potential of Volatile Terpenes and Terpenoids from Forests for Inflammatory Diseases

Kim

Song

Cho

et al. 2020

IJMS

174

131

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Forest trees are a major source of biogenic volatile organic compounds (BVOCs). Terpenes and terpenoids are known as the main BVOCs of forest aerosols. These compounds have been shown to display a broad range of biological activities in various human disease models, thus implying that forest aerosols containing these compounds may be related to beneficial effects of forest bathing. In this review, we surveyed studies analyzing BVOCs and selected the most abundant 23 terpenes and terpenoids emitted in forested areas of the Northern Hemisphere, which were reported to display anti-inflammatory activities. We categorized anti-inflammatory processes related to the functions of these compounds into six groups and summarized their molecular mechanisms of action. Finally, among the major 23 compounds, we examined the therapeutic potentials of 12 compounds known to be effective against respiratory inflammation, atopic dermatitis, arthritis, and neuroinflammation among various inflammatory diseases. In conclusion, the updated studies support the beneficial effects of forest aerosols and propose their potential use as chemopreventive and therapeutic agents for treating various inflammatory diseases.

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Wound healing activity of terpinolene and α-phellandrene by attenuating inflammation and oxidative stress in vitro

Cited by 87 publications

References 39 publications

Cymbopogon Proximus Essential Oil Protects Rats against Isoproterenol-Induced Cardiac Hypertrophy and Fibrosis

Cymbopogon Proximus Essential Oil Protects Rats against Isoproterenol-Induced Cardiac Hypertrophy and Fibrosis

Untargeted and Targeted Metabolomic Profiling of Australian Indigenous Fruits

Therapeutic Potential of Volatile Terpenes and Terpenoids from Forests for Inflammatory Diseases

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