Wound Healing Agents: The Role of Natural and Non-Natural Products in Drug Development

Abstract

Impaired wound healing leads to infection and tissue necrosis. This has spurred the search for wound healing agents derived from natural and non-natural sources. Although natural products are widely used as lead compounds for the design of therapeutic drugs, few studies have looked for potential wound healing compounds in nature. In this review, we briefly discuss each phase of the wound healing process. Examples of natural and non-natural products with wound healing activities are listed, and the structure-activity relationship of fifty one compounds are described. An understanding of how these compounds exert their activities in biological systems is essential for their future development and application as wound healing agents.

Silver Nanoparticles as Real Topical Bullets for Wound Healing

“…To prevent extensive loss and damage to the tissue, skin grafting 64 and biological dressings 65 were developed. In order to heal the larger wound, the skin surface must be covered with sufficient dressing, even it is temporary.…”

The Influence of Tribenoside on Expression and Deposition of Epidermal Laminins in HaCaT Cells

“…Some agents promote wound healing without disturbing the biological process. 24) Tribenoside, used for treatment of hemorrhoidal disease, promotes not only improvement of microcirculation but also wound healing. In human epidermal cells, tribenoside up-regulated the transcription of laminin a5, which is a major component of epidermal BMs.…”

Nitric oxide based strategies for applications of biomedical devices

“…NO has excellent anti-bacterial properties, which is of great importance to wound healing. Moreover, NO is widely believed to be responsible for promoting wound healing by re-epithelialization, improving angiogenesis by stimulating growth factor expression and increasing collagen synthesis [177,178]. Thus NO is essential to wound healing.…”