2006
DOI: 10.1097/01.prs.0000222562.60260.f9
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Wound Healing: An Overview

Abstract: Understanding wound healing today involves much more than simply stating that there are three phases: inflammation, proliferation, and maturation. Wound healing is a complex series of reactions and interactions among cells and "mediators." Each year, new mediators are discovered and our understanding of inflammatory mediators and cellular interactions grows. This article will attempt to provide a concise overview on wound healing and wound management.

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Cited by 689 publications
(648 citation statements)
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References 267 publications
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“…These seemingly contradictory data might be reconcile if one considers that the wound healing process is complex, consisting of four distinct phases. These are the homeostasis phase (immediately upon injury; mainly characterized by rapid thrombus formation), the inflammation phase (up to 4-6 days after injury; leading to the recruitment of inflammatory cells), the migration phase (up to 6-8 days upon injury; mostly featuring the accumulation of fibroblasts and the production of extracellular matrix structures), and the remodelling phase (day 8 through 1 year after injury) [17,18]. The migration phase is sometimes termed proliferation phase (day 4 through 14 after injury) [17].…”
Section: Introductionmentioning
confidence: 99%
“…These seemingly contradictory data might be reconcile if one considers that the wound healing process is complex, consisting of four distinct phases. These are the homeostasis phase (immediately upon injury; mainly characterized by rapid thrombus formation), the inflammation phase (up to 4-6 days after injury; leading to the recruitment of inflammatory cells), the migration phase (up to 6-8 days upon injury; mostly featuring the accumulation of fibroblasts and the production of extracellular matrix structures), and the remodelling phase (day 8 through 1 year after injury) [17,18]. The migration phase is sometimes termed proliferation phase (day 4 through 14 after injury) [17].…”
Section: Introductionmentioning
confidence: 99%
“…Nevertheless, during the mal nu tri tion pro cess, col la gen depo si tion falls, com pro mi sing the func tion of col la gen in healing the skin. 15,26,27 The results shown in the two models of mal nutri tion were simi lar irres pec ti ve of the model used, sho wing the nega ti ve effect of mal nu tri tion on skin tro phism in these ani mals, an effect that was con fir - …”
Section: Discussionmentioning
confidence: 86%
“…It refers to a cascade of events that begins with the trauma and ends with the complete and organized closure of the wound with the scar tissue [1][2][3]. The skin is one of the organs most susceptible to injury and needs regeneration to restore its structure and functions, such as protective physical barrier against various environmental stimuli and infections and against excessive water loss [3][4][5]. According to Broughton et al [5], after the skin damage, the wound process is common to all wounds, regardless of the causative agent, being systemic and dynamic and directly related to the general conditions of the organism [6,7].…”
Section: Introductionmentioning
confidence: 99%
“…The skin is one of the organs most susceptible to injury and needs regeneration to restore its structure and functions, such as protective physical barrier against various environmental stimuli and infections and against excessive water loss [3][4][5]. According to Broughton et al [5], after the skin damage, the wound process is common to all wounds, regardless of the causative agent, being systemic and dynamic and directly related to the general conditions of the organism [6,7]. Wound healing is classically divided into three stages: a) Inflammation b) Formation of granulation tissue with extracellular matrix deposition (fibroblastic proliferation) and c) Remodelling (including reepithelialisation), (Figure 1) [5,[8][9][10][11].…”
Section: Introductionmentioning
confidence: 99%