Wound-healing and cytokine-modulating potential of medicinal oil formulation comprising leaf extract of Murraya koenigii and olive oil

Abstract

The study investigated the wound healing effect of medicinal oil (MO) formulation prepared from Murraya koenigii leaves extract (methanolic) incorporated in olive oil. The MO was visually transparent, homogenous, smooth in texture, the viscosity grade was observed as 140 cP and easily spreadable. Pro-inflammatory cytokines IL-1β, IL-6, and TNF-α were significantly reduced to 82.3 ± 3.5, 156 ± 6.2, 137.3. ± 5.5 pg/ml, respectively after treatment with MO when compared to disease control animals that showed IL-1β, IL-6, and TNF-α levels of 170 ± 6, 265 ± 7, and 288.6 ± 11, pg/ml respectively. The level of pro-inflammatory cytokine in povidone iodine solution (PIS) group was 95.3 ± 3, 162 ± 6, 177.6 ± 8.9 pg/ml of IL-1β, IL-6, and TNF-α respectively. Interestingly, the wound-healing efficacy of MO was found better as compared to povidone iodine treated standard group and concluded that MO has excellent wound healing effect.

Histopathological Evaluation of the Healing Process of Standardized Skin Burns in Rabbits: Assessment of a Natural Product with Honey and Essential Oils

“…Sesame oil is rich in many biological active ingredients especially β-sitosterol [ 7 , 8 , 37 , 51 ], which is the active ingredient of a commercially available cream (MEBO ® -cream). Additionally, olive oil has been used in various previous studies investigating its role in the wound healing process [ 8 , 43 , 52 , 53 ].…”

Phyto‐Pharmacological Review onMurraya koenigii(L.) Spreng: As an Indigenous Plant of India with High Medicinal Potential

“…Research investigated the wound healing activity of medicated oil formulation obtained from methanol leaf extract of M. koenigii along with olive oil. After treatment given with medicated oil to the treatment group animals, it showed potential reduced effect in inflammatory cytokines such as IL‐6, TNF‐alpha and IL‐1β, compared to povidone iodine solution treated group, respectively [57] …”

“…After treatment given with medicated oil to the treatment group animals, it showed potential reduced effect in inflammatory cytokines such as IL-6, TNF-alpha and IL-1β, compared to povidone iodine solution treated group, respectively. [57]…”