Wound healing and<i>in vitro</i>antiradical activity of five<i>Sedum</i>species grown within two sites of community importance in Emilia-Romagna (Italy)

Chiocchio, Ilaria; Poli, Ferruccio; Governa, Paolo; Biagi, Marco; Lianza, Mariacaterina

doi:10.1080/11263504.2018.1549611

Cited by 14 publications

(14 citation statements)

References 31 publications

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“…where A 0 is the absorbance of a standard that was prepared in the same conditions, but without any sample, and A 1 is the absorbance of the analyzed samples. The scavenger ability of the sample toward DPPH specie was expressed as IC 50 value [31]. Each measurement was carried out in triplicate and data expressed as means (± SD).…”

Section: Determination Of Scavenging Activity On Dpph Radicalsmentioning

confidence: 99%

Sangiovese cv Pomace Seeds Extract-Fortified Kefir Exerts Anti-Inflammatory Activity in an In Vitro Model of Intestinal Epithelium Using Caco-2 Cells

et al. 2020

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Inflammatory bowel disease and food allergies are a growing topic in the field of nutrition science. Polyphenols, which are the most important secondary metabolites of plants, demonstrated to modulate the expression and/or production of numerous proteins, but also to regulate the intestinal ecosystem. In this context, our aim was the investigation of protective effects against the gastrointestinal mucosa of fortified milk kefir obtained by adding seeds extract from Sangiovese cv. Pomace. Methods: An ultrasound-assisted method was used to obtain the extracts. All the extracts were assayed for the antioxidant activity. The best extract was used as an additive of fermented milk kefir to obtain a fortified final product. Kefir samples were analyzed by NMR spectroscopy. The efficiency of the barrier functions was evaluated by measuring trans-epithelial electric resistance (TEER) using a voltmeter. Results: the enriched kefir (Ksgn) possesses higher antioxidant performances compared to the unfortified sample (Kwht). Kwht and Ksgn did not alter Caco-2 TEER in basal condition.

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Section: Determination Of Scavenging Activity On Dpph Radicalsmentioning

confidence: 99%

Sangiovese cv Pomace Seeds Extract-Fortified Kefir Exerts Anti-Inflammatory Activity in an In Vitro Model of Intestinal Epithelium Using Caco-2 Cells

et al. 2020

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“…We also found that the dose-effect relationship of TMM was biphasic, showing a bell-shaped effect. Natural products have been frequently shown to have a biphasic pharmacological effect, both in vitro and in vivo [ 38 , 39 , 40 ]. In particular, we previously reported that a standardized Hypericum perforatum L. extract, which is a well-known anti-depressant herbal drug, can exert an anti-nociceptive effect in mice models of neuropathic pain at lower doses compared to the one used for treating depression, with a mechanism of action involving the opioid system.…”

Section: Discussionmentioning

confidence: 99%

Novel Therapeutic Approach for the Management of Mood Disorders: In Vivo and In Vitro Effect of a Combination of L-Theanine, Melissa officinalis L. and Magnolia officinalis Rehder & E.H. Wilson

et al. 2020

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Mood disorders represent one of the most prevalent and costly psychiatric diseases worldwide. The current therapies are generally characterized by several well-known side effects which limit their prolonged use. The use of herbal medicine for the management of several psychiatric conditions is becoming more established, as it is considered a safer support to conventional pharmacotherapy. The aim of this study was to investigate the possible anxiolytic and antidepressant activity of a fixed combination of L-theanine, Magnolia officinalis, and Melissa officinalis (TMM) in an attempt to evaluate how the multiple modulations of different physiological systems may contribute to reducing mood disorders. TMM showed an anxiolytic-like and antidepressant-like activity in vivo, which was related to a neuroprotective effect in an in vitro model of excitotoxicity. The effect of TMM was not altered by the presence of flumazenil, thus suggesting a non-benzodiazepine-like mechanism of action. On the contrary, a significant reduction in the effect was observed in animals and neuronal cells co-treated with AM251, a cannabinoid receptor type 1 (CB1) antagonist, suggesting that the endocannabinoid system may be involved in the TMM mechanism of action. In conclusion, TMM may represent a useful and safe candidate for the management of mood disorders with an innovative mechanism of action, particularly as an adjuvant to conventional therapies.

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“…Moreover, the wound-healing capacity of polyphenol-enriched products, such as honey, may result from an elaborate balance between the anti-inflammatory and immune-stimulatory effect of polyphenols [41]. At high concentration, or after prolonged exposure, polyphenols are able to reduce the production of pro-inflammatory cytokines and interact with cells metabolism and proliferation, thus reducing wound healing [27].…”

Section: Discussionmentioning

confidence: 99%

“…The scratch wound-healing assay was applied by slightly modifying the protocol of Chen (2012) [26], as previously described [27]. Briefly, HaCaT cells (5 × 10 4 ) were seeded into six-well cell culture plates and allowed to grow to 70–80% confluence as a monolayer.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of the In Vitro Wound-Healing Activity of Calabrian Honeys

et al. 2019

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The healing of skin wounds and particularly chronic wounds, such as diabetic foot ulcers, is still a clinical emergency. Despite the many therapeutic tools that are available so far, none seems to be really effective and safe. In this context, we highlighted the renewed wound healing activity of honey, a viscous aromatic and sweet food, by way of in vitro wound-healing assays, using the HaCaT cell line. Specifically, we investigated five monofloral or multifloral honeys from different Calabrian provinces using them as such or extracted (by Amberlite® or n-hexane and ethyl acetate). The chemical composition of honeys was ascertained by 1H NMR spectroscopy and by the gas chromatography/mass spectrometry (GC/MS) method for volatile organic compounds (VOCs). Amongst the five tested honeys, BL1 and BL5 honeys showed the most promising healing properties. Pinocembrin, which was revealed in BL1 (multifloral) and BL5 (orange) honey samples, is a flavanol that is already known to possess interesting biological activities, including healing. This study aims to investigate how a traditional food such as honey, which is appreciated for its nutritional value and used in folk medicine, can be enhanced as an effective modern remedial to promote a multifaceted and safe healing activity for all skin wounds.

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Wound healing andin vitroantiradical activity of fiveSedumspecies grown within two sites of community importance in Emilia-Romagna (Italy)

Cited by 14 publications

References 31 publications

Sangiovese cv Pomace Seeds Extract-Fortified Kefir Exerts Anti-Inflammatory Activity in an In Vitro Model of Intestinal Epithelium Using Caco-2 Cells

Sangiovese cv Pomace Seeds Extract-Fortified Kefir Exerts Anti-Inflammatory Activity in an In Vitro Model of Intestinal Epithelium Using Caco-2 Cells

Novel Therapeutic Approach for the Management of Mood Disorders: In Vivo and In Vitro Effect of a Combination of L-Theanine, Melissa officinalis L. and Magnolia officinalis Rehder & E.H. Wilson

Evaluation of the In Vitro Wound-Healing Activity of Calabrian Honeys

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