Wound Healing and Management

McCulloch, Joseph

doi:10.1016/b978-156053708-3.50029-5

Cited by 6 publications

(12 citation statements)

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“…An effective means of promoting wound healing is electrical stimulation [1][2][3][4]. Despite many studies on wound healing, the application of electrical stimulation is still in its infancy because of the varied and inconsistent modes of stimulation used and results obtained among the studies [1][2].…”

Section: Introductionmentioning

confidence: 99%

“…Despite many studies on wound healing, the application of electrical stimulation is still in its infancy because of the varied and inconsistent modes of stimulation used and results obtained among the studies [1][2]. An important parameter of electrical stimulation in wound healing is the type of applied polarity, which may affect protein synthesis, cell migration, growth of bacteria, galvanotaxis, inflammation, edema, and also the processes of bioelectric events of injury [1][2]5].…”

Section: Introductionmentioning

confidence: 99%

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Anodal and cathodal pulsed electrical stimulation on skin wound healing in guinea pigs

Mehmandoust¹,

Torkaman²,

Firoozabadi³

et al. 2007

JRRD

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Abstract-We investigated the effects of anodal and cathodal electrical stimulation on wound healing. In a randomized controlled trial, we divided 42 male albino guinea pigs into two control (C1 and C2) and four experimental (E1-E4) groups. A 3 cm linear incision was made at the dorsal skin of all guinea pigs. A unidirectional pulse current of 300 to 600 microamperes, 80 pps, and 0.3 ms pulse duration was administered for 1 hour a day. In groups E1 and E3 (anodal), a positive polarity was applied for the first 3 days followed by negative polarity the remaining days. In groups E2 and E4 (cathodal), negative polarity was applied for the first 3 days and positive polarity the remaining days. Groups E1, E2, and C1 were killed on day 14 and E3, E4, and C2 on day 21. We measured the percentage of decrease in wound surface area (daily tracing) and tensile strength (on days 14 and 21). The results indicated that both cathodal and anodal stimulations increased the rate of wound closure. Beginning with day 12, we saw a significant difference in the percentage of the decrease in wound surface between all treatment and control groups (p < 0.05). Ultimate tensile strength and stress increased in the anodal compared with the cathodal and control groups; at the end of day 14, ultimate tensile stress in E1 was significantly greater compared with C1 (p < 0.05). We conclude that electrical stimulation, regardless of polarity regimen, benefits wound healing, but anodal stimulation the first 3 days and cathodal stimulation the remaining days can lead to stronger repaired tissue.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anodal and cathodal pulsed electrical stimulation on skin wound healing in guinea pigs

Mehmandoust¹,

Torkaman²,

Firoozabadi³

et al. 2007

JRRD

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“…Dyson (1987), Kitchen & Partridge (1990) warn that the possible problems of heating at higher doses can be damaging to tissue. McCulloch et al (1995) report that some of the physiological changes induced by therapeutic US that can affect the healing process are primarily of nonthermal origin.…”

Section: Physiological Effects Of Ultrasoundmentioning

confidence: 99%

“…Williams (1987) reported the functions of a coupling medium are simply to exclude air from the region between the transducer and the patient so that US can get to the site to be treated. McCulloch et al (1995) described the ideal coupling medium. They felt that it should have the same acoustic impedance as skin, excellent ultrasonic propagation properties, and the ability to double as a wound dressing.…”

Section: Physics Of Ultrasoundmentioning

confidence: 99%

“…The goals of facilitating wound healing, repairing injured tissues, preventing infection, maximizing wound strength and preventing disability have been sought by many throughout history. Wound management is best attained by using a multidisciplinary team approach, (McCulloch, Kloth, & Feedar, 1995;Sparks, 1994) and physical therapists play a logical role in this team. Physical therapists can add unique treatments to the plan of care in wound management.…”

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confidence: 99%

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The effects of therapeutic ultrasound on open wounds

Bloyer¹

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IntroductionThe problem of wound healing has long presented challenges to those in the medical profession. The goals of facilitating wound healing, repairing injured tissues, preventing infection, maximizing wound strength and preventing disability have been sought by many throughout history. Wound management is best attained by using a multidisciplinary team approach, (McCulloch, Kloth, & Feedar, 1995;Sparks, 1994) and physical therapists play a logical role in this team. Physical therapists can add unique treatments to the plan of care in wound management. These treatments include electrotherapy, ultrasound (US), and hydrotherapy, as well as mobility and positioning techniques and devices.Byl, Mckenzie, West, Whitney, Hunt, and Sceuenstuhl (1992) wrote that the most frequently used technique to accelerate wound healing is the application of heat.However, they hypothesized that deep heat such as US might be more effective than superficial heat. Their study concluded that low-dose ultrasound would facilitate wound healing. Riet, Kessels, and Knipschild (1996) found in their research that the data did not support the idea that US speeds up the healing of pressure ulcers. The literature on the effectiveness of US in accelerating healing is incomplete, conflicting and inconclusive.Wound healing is a complex process involving the synthesis of intracellular and extracellular materials. Vascular responses and release of chemical mediators within wounded tissues combine to form inherent interrelated components of the healing process . The biological effects of US, if applied correctly, should produce physiological changes that could accelerate wound healing and other tissue repair . & Meneses, 1995;McCulloch, 1995;Sparks, 1994). Review of Literature Physics of UltrasoundUltrasound (US) has been used in medicine for over 50 years, and its biological effects on tissue were first reported by Wood and Loomis in 1927. Lysis of red blood cells and decreased mobility in mice following exposure to high-frequency (300kHz),high intensity sound waves were demonstrated. Ultrasound for medical treatment was introduced in Germany in the late 1930's according to Michlovitz (1996) and in the United States in the late 1940 's (Michlovitz, 1996. Ultrasound has a variety of uses in contemporary medicine including diagnostic imaging of internal structures, functional restoration and healing of soft tissue conditions, tissue destruction, and hyperthermia for tumor irradiation according to Michlovitz (1996). The intensity of US in each varies, with the lowest intensity used for diagnostic purposes and the highest for tissue destruction.Ultrasound is defined as a non-ionizing radiation; an inaudible, acoustic, mechanical vibration transmitted at a frequency above the upper limit of human hearing . Solids and liquids consist of molecules held together by elastic forces that behave like rubber bands connecting each molecule to its neighbor. If the molecule is vibrated, it will cause the neighboring molecule to vibrate. This will continue unt...

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ATP Release and P₂Y Receptor Signaling are Essential for Keratinocyte Galvanotaxis

Riding

Pullar

2015

Journal Cellular Physiology

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Repair to damaged tissue requires directional cell migration to heal the wound. Immediately upon wounding an electrical guidance cue is created with the cathode of the electric field (EF) located at the center of the wound. Previous research has demonstrated directional migration of keratinocytes toward the cathode when an EF of physiological strength (100-150 mV/mm) is applied in vitro, but the "sensor" by which keratinocytes sense the EF remains elusive. Here we use a customized chamber design to facilitate the application of a direct current (DC) EF of physiological strength (100 mV/mm) to keratinocytes whilst pharmacologically modulating the activation of both connexin hemichannels and purinergic receptors to determine their role in EF-mediated directional keratinocyte migration, galvanotaxis. In addition, keratinocytes were exposed to DiSCAC2 (3) dye to visualize membrane potential changes within the cell upon exposure to the applied DC EF. Here we unveil ATP-medicated mechanisms that underpin the initiation of keratinocyte galvanotaxis. The application of a DC EF of 100 mV/mm releases ATP via hemichannels activating a subset of purinergic P2 Y receptors, locally, to initiate the directional migration of keratinocytes toward the cathode in vitro, the center of the wound in vivo. The delineation of the mechanisms underpinning galvanotaxis extends our understanding of this endogenous cue and will facilitate the optimization and wider use of EF devices for chronic wound treatment. J. Cell. Physiol. 230: 181-191, 2016. © 2015 Wiley Periodicals, Inc.

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Wound Healing and Management

Cited by 6 publications

References 0 publications

Anodal and cathodal pulsed electrical stimulation on skin wound healing in guinea pigs

Anodal and cathodal pulsed electrical stimulation on skin wound healing in guinea pigs

The effects of therapeutic ultrasound on open wounds

ATP Release and P₂Y Receptor Signaling are Essential for Keratinocyte Galvanotaxis

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Wound Healing and Management

Cited by 6 publications

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Anodal and cathodal pulsed electrical stimulation on skin wound healing in guinea pigs

Anodal and cathodal pulsed electrical stimulation on skin wound healing in guinea pigs

The effects of therapeutic ultrasound on open wounds

ATP Release and P2Y Receptor Signaling are Essential for Keratinocyte Galvanotaxis

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ATP Release and P₂Y Receptor Signaling are Essential for Keratinocyte Galvanotaxis