Wound healing, antimicrobial and antioxidant properties of the leaf and stem bark of Entada africana Guill. &amp; Perr.

Baidoo, Michael Frimpong; Mensah, Abraham Yeboah; Ossei, Paul Poku Sampene; Asante-Kwatia, Evelyn; Amponsah, Isaac Kingsley

doi:10.1016/j.sajb.2020.09.037

Cited by 14 publications

(8 citation statements)

References 33 publications

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“…and Entada africana Guill. & Perr ( Baidoo et al, 2021 ). have reported the use of plant extracts enriched with phenolic compounds accelerate the wound healing activity due to their higher antioxidant, anti-inflammatory and antimicrobial properties.…”

Section: Discussionmentioning

confidence: 99%

“…Antioxidants are the agents that convert ROS into more stable molecules through complex cascade of reactions and protect the cells from being damaged by these free radicals. It has been attributed that the antioxidant activities of plant extracts are mainly due to high phenolic and flavonoid content and they are positively correlated with wound healing efficacy ( Agyare et al, 2013 ; Vittorazzi et al, 2016 ; Baidoo et al, 2021 ). Our results suggest that the significant antioxidant property of PEF might have contributed to a great extent in the observed wound healing activity.…”

Section: Discussionmentioning

confidence: 99%

“…Effective antimicrobial agents enhance the wound healing process in one or more phases by forming a barrier against infectious microbes. Therefore, the topical application of active antimicrobial agents is one of the efficient wound healing therapies to alleviate the possible wound infections ( Suntar et al, 2013 ; Baidoo et al, 2021 ). In the present study PEF showed broad spectrum of antimicrobial activity against microbial skin pathogens with significant MIC and ZI, even more than crude ethanol extract.…”

Section: Discussionmentioning

confidence: 99%

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Attenuation of dermal wounds through topical application of ointment containing phenol enriched fraction of Caesalpinia mimosoides Lam.

Bhat

Upadhya²,

Hegde

et al. 2022

Front. Pharmacol.

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Caesalpinia mimosoides Lam. is one of the important medicinal plants used by the traditional healers of Uttara Kannada district, Karnataka (India) for treating wounds. In our previous study ethanol extract of the plant was evaluated for its wound healing activity. In continuation, the present study was aimed to evaluate the phenol enriched fraction (PEF) of ethanol extract for wound healing activity along with its antioxidant, anti-inflammatory and antimicrobial properties. The potent wound healing activity of PEF was evidenced by observation of increased rate of cell migration in L929, 3T3L1 and L6 cells (92.59 ± 1.53%, 98.42 ± 0.82% and 96.63 ± 0.61% respectively) at 7.81 μg/ml doses in assays carried out in vitro. Significantly enhanced rate of wound contraction (97.92 ± 0.41%), tensile strength (973.67 ± 4.43 g/mm2), hydroxyproline (31.31 ± 0.64 mg/g) and hexosamine (8.30 ± 0.47 mg/g) contents were observed on 15th post wounding day in 5% PEF treated animals. The enzymatic and non-enzymatic cellular antioxidants (superoxide dismutase, catalase and reduced glutathione) were upregulated (15.89 ± 0.17 U/mg, 48.30 ± 4.60 U/mg and 4.04 ± 0.12 μg/g respectively) with the administration of 5% PEF. The significant antimicrobial, antioxidant and anti-inflammatory activities support the positive correlation of PEF with its enhanced wound healing activity. PEF contains expressive amounts of total phenolic and total flavonoid contents (578.28 ± 2.30 mg GAE/g and 270.76 ± 2.52 mg QE/g). Of the various chemicals displayed in RP-UFLC-DAD analysis of PEF, gallic acid (68.08 μg/mg) and ethyl gallate (255.91 μg/mg) were predominant. The results indicate that PEF has great potential for the topical management of open wounds.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Attenuation of dermal wounds through topical application of ointment containing phenol enriched fraction of Caesalpinia mimosoides Lam.

Bhat

Upadhya²,

Hegde

et al. 2022

Front. Pharmacol.

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“…In a previous study, the MeOH–CH 2 Cl 2 (1:1) extract of A. petrocarpoides roots exhibited DPPH radical scavenging effect (IC 50 = 63.59) [ 14 ]. Previous works have demonstrated a positive correlation between phenolic content, antioxidant activity and wound healing effects of plant extracts [ 41 , 42 ]. This suggests that the amount of phenolic content in A. pterocarpoides greatly influences its antioxidant activity and in turn its wound healing activity.…”

Section: Discussionmentioning

confidence: 99%

Amphimas pterocarpoides harms.: An Evaluation of flavonoid and phenolic contents, wound healing, anthelmintic and antioxidant activities of the leaves and stem bark

Asante-Kwatia

Adjei

Jibira

et al. 2021

Heliyon

Self Cite

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“…Baidoo et al [ 126 ] investigated the wound healing, antimicrobial and anti-oxidant activities of methanol extracts of the leaf and stem of E. africana tested in the dermal excision wound model in rats. The methanol extract of bark stem, having GA as the main phenolic compound, demonstrated antibacterial activity against Staphylococcus aureus and Streptococcus pyogenes with a minimum inhibitory concentration of 1.56 mg/mL and thereby a great potential for the treatment of open wounds.…”

Section: Biochemical and Health Properties Of The Examined Phenolic Acidsmentioning

confidence: 99%

A Review of the Health Protective Effects of Phenolic Acids against a Range of Severe Pathologic Conditions (Including Coronavirus-Based Infections)

Kiokias

Oreopoulou

2021

Molecules

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Phenolic acids comprise a class of phytochemical compounds that can be extracted from various plant sources and are well known for their antioxidant and anti-inflammatory properties. A few of the most common naturally occurring phenolic acids (i.e., caffeic, carnosic, ferulic, gallic, p-coumaric, rosmarinic, vanillic) have been identified as ingredients of edible botanicals (thyme, oregano, rosemary, sage, mint, etc.). Over the last decade, clinical research has focused on a number of in vitro (in human cells) and in vivo (animal) studies aimed at exploring the health protective effects of phenolic acids against the most severe human diseases. In this review paper, the authors first report on the main structural features of phenolic acids, their most important natural sources and their extraction techniques. Subsequently, the main target of this analysis is to provide an overview of the most recent clinical studies on phenolic acids that investigate their health effects against a range of severe pathologic conditions (e.g., cancer, cardiovascular diseases, hepatotoxicity, neurotoxicity, and viral infections—including coronaviruses-based ones).

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Wound healing, antimicrobial and antioxidant properties of the leaf and stem bark of Entada africana Guill. & Perr.

Cited by 14 publications

References 33 publications

Attenuation of dermal wounds through topical application of ointment containing phenol enriched fraction of Caesalpinia mimosoides Lam.

Attenuation of dermal wounds through topical application of ointment containing phenol enriched fraction of Caesalpinia mimosoides Lam.

Amphimas pterocarpoides harms.: An Evaluation of flavonoid and phenolic contents, wound healing, anthelmintic and antioxidant activities of the leaves and stem bark

A Review of the Health Protective Effects of Phenolic Acids against a Range of Severe Pathologic Conditions (Including Coronavirus-Based Infections)

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