Wound‐healing effect of acupuncture for treating phonotraumatic vocal pathologies: A cytokine study

Yiu, Eml; Chan, Karen M. K.; Li, Nicole Y. K.; Tsang, Raymond Chi-Chung; Abbott, Katherine Verdolini; Kwong, Elizabeth; P.-M., Estella; Tse, Fred W.; Lin, Zhi‐Xiu

doi:10.1002/lary.25483

Cited by 12 publications

(9 citation statements)

References 26 publications

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“…In a separate study that investigated the anti-inflammatory effect of acupuncture, a wound-healing hypothesis of acupuncture was proposed. The study found that anti-inflammatory cytokine increased following genuine but not sham acupuncture 38 . It was concluded that acupuncture enhances the anti-inflammatory effect in vocal fold lesion healing.…”

Section: Discussionmentioning

confidence: 84%

Is Acupuncture Efficacious for Treating Phonotraumatic Vocal Pathologies? A Randomized Control Trial

et al. 2016

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Objective To investigate the effectiveness of acupuncture in treating phonotraumatic vocal fold lesions. Study Design/Methods A total of 123 dysphonic individuals with benign vocal pathologies were recruited. They were given either genuine acupuncture (N=40), sham acupuncture (N=44) or a no-treatment (N=39) for six weeks (two 30-minute sessions per week). The genuine acupuncture group received needles puncturing nine voice-related acupoints for 30 minutes, two times a week for six weeks; while the sham acupuncture group received blunted needles stimulating the skin surface of the nine acupoints for the same frequency and duration. The no-treatment group did not receive any intervention but attended just the assessment sessions. One hundred and seventeen subjects completed the study (genuine acupuncture=40; sham acupuncture=43, and no-treatment=34), but only 84 of them had a complete set of vocal functions and quality of life measures (genuine acupuncture=29; sham acupuncture=33, and no-treatment=22), and 42 of them with a complete set of endoscopic data (genuine acupuncture=16; sham acupuncture=15 and no-treatment=11). Results Significant improvement in vocal function, as indicated by the maximum fundamental frequency produced, and also perceived quality of life, were found in both the genuine and sham acupuncture groups, but not in the no-treatment group. Structural (morphological) improvements were, however, only noticed in the genuine acupuncture group, which demonstrated a significant reduction in the size of the vocal fold lesions. Conclusions The findings showed that acupuncture of voice-related acupoints could bring about improvement in vocal function and healing of vocal fold lesions.

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Section: Discussionmentioning

confidence: 84%

Is Acupuncture Efficacious for Treating Phonotraumatic Vocal Pathologies? A Randomized Control Trial

et al. 2016

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“…Locally, each plays a role in wound healing. During wound repair, acupuncture can increase serum immunoglobulin, increase the leukocyte phagocytic index and lymphocyte transformation rate, and enhance the body's anti-infective ability, which can alleviate local prolonged inflammatory response (30,31). Acupuncture can adjust the inflammatory response and immune regulation of the body to the injury in various ways and enhance the tissue repair process.…”

Section: Discussionmentioning

confidence: 99%

An mRNA sequencing analysis of the healing-promoting role of electroacupuncture a in rat skin wound model

Bao

et al. 2020

Ann Palliat Med

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Background: Many studies have confirmed that electroacupuncture can regulate the body's environment to treat a variety of diseases. However, there are few reports on the mechanism of electroacupuncture therapy for diseases involving skin injury. Transcriptome sequencing can reveal changes in gene expression within cells and the signaling pathways involved. In this study, we used transcriptome sequencing to study the molecular mechanisms by which electroacupuncture promotes the healing of skin lesions.Methods: A total of 10 SD rats were divided into two groups of 5: a control group and an electroacupuncture treatment group. The wound-healing area was compared between the two groups after 3 and 14 days. Then, mRNA sequencing and bioinformatics were used to analyze the changes in gene expression profiles in skin tissue after electroacupuncture stimulation.Results: (I) The wound area was significantly reduced after 3 and 14 days of electroacupuncture compared with the control group (P<0.05). (II) There was a total of 694 gene expression changes, 496 of which were upregulated and 198 of which were downregulated. Analysis of variable gene-related signaling pathways by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG), identified immuneinflammatory response, cell proliferation, tissue remodeling, cell metabolism, graft-versus-host disease, antigen processing and presentation, Th17 cell differentiation, cytokine-cytokine receptor interaction, PPAR signaling pathway, Wnt signaling pathway and other signaling pathways were changed.Conclusions: Electroacupuncture can promote wound repair, as shown by the changes in gene expression profiles during the healing of skin wounds under electroacupuncture. This study provides a scientific basis that deepens the understanding of the mechanism underlying electroacupuncture.

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“…Proinflammatory cytokines IL-1 beta, IL-2, IL-8, and IL-18; C-reactive protein (CRP) [37,38]; and TNF alpha, the anti-inflammatory cytokines IL-4 and IL-10 [37], and the dual pro/anti-inflammatory IL-6 [39] will be measured to determine if there is a significant change from baseline to post study (5 week). Venous blood (4.5 mL) will be collected in a blue-top collection tube containing 3.2% sodium citrate.…”

Section: Methodsmentioning

confidence: 99%

Acupuncture to Improve Symptoms for Stable Angina: Protocol for a Randomized Controlled Trial

Schlaeger¹,

Cai²,

Steffen³

et al. 2019

JMIR Res Protoc

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Background Acupuncture has demonstrated physiologic analgesic effects in Chinese patients with stable angina. One proposed mechanism of action for these analgesic effects is the downregulation of M1 macrophages, interleukin 1 beta, interleukin-6, interleukin-18, and tumor necrosis factor alpha. Objective This study aims to test a 10-session, 5-week acupuncture treatment protocol as a complementary therapy for symptoms of stable angina for American patients, who vary from Chinese patients in health care systems and other salient variables. Methods We are conducting a randomized controlled trial (RCT) of 69 adults (35 assigned to initial acupuncture and 34 to an attention control condition) with a medically confirmed diagnosis of stable angina, whose pain and associated symptoms have not been controlled to their satisfaction with guideline-directed medical management. Participants in the experimental group will receive a standardized traditional Chinese medicine point prescription. The attention control group will view non–pain-related health education videos over 5 weeks equal to the 10 hours of treatment for the acupuncture group. Participants will complete the McGill Pain Questionnaire and the Seattle Angina Questionnaire-7, as well as have inflammatory cytokines measured at baseline and study completion. The primary outcomes are anginal pain and quality of life. Results This study has been funded over 2 years by the National Institutes of Health, National Institute for Nursing Research. We are currently recruiting and expect to have initial results by December 2020. Conclusions We will generate data on feasibility, acceptability, effect sizes, and protocol revisions for a future fully powered RCT of the protocol. Findings will help determine if patients with persistent ischemic symptoms experience a proinflammatory state and hyperalgesia caused by multiple neural and immune processes not always relieved with medication. International Registered Report Identifier (IRRID) DERR1-10.2196/14705

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Wound‐healing effect of acupuncture for treating phonotraumatic vocal pathologies: A cytokine study

Cited by 12 publications

References 26 publications

Is Acupuncture Efficacious for Treating Phonotraumatic Vocal Pathologies? A Randomized Control Trial

Is Acupuncture Efficacious for Treating Phonotraumatic Vocal Pathologies? A Randomized Control Trial

An mRNA sequencing analysis of the healing-promoting role of electroacupuncture a in rat skin wound model

Acupuncture to Improve Symptoms for Stable Angina: Protocol for a Randomized Controlled Trial

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