Wound Healing Effect of an Ointment Made From a Mixture of Brassica oleracea var, Punica granatum, and Plantago major L Extracts in Rats

Bazafkan, Mohammad Hassan; Hardani, Ameneh; Zadeh, Mohammad Reza Afzal; Zargar, Ashraf Amir; Zadeh, Mahmoud Orazi; Hemmati, Ali Asghar; Mansori, Esrafil; Asadi-Samani, Majid; Ghasemiboroon, Maryam; Kooti, Vesam

doi:10.17795/jjhr-21877

Cited by 4 publications

(3 citation statements)

References 23 publications

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“…Another study has revealed that linoleic acid can increase the production of VEGF in various cell types such as macrophages, and cancer cells (Rodrigues et al, 2016). Furthermore, one of the possible mechanisms for the effect of plantago major L on such conditions is the contractile property of smooth muscles such as vasoconstriction, which is resulted from some of its active compounds (Bazafkan et al, 2014;Nejati et al, 2018). Another mechanism that might be involved is the generation of reactive oxygen species (ROS) that modulate the expression and activity of angiogenic factors and signaling pathways (Asif et al, 2016;Entezari Heravi et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

A Double-blind, Randomized Clinical Trial Study of Plantago major l. Syrup on Menorrhagia

2024

J Angiotherapy

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Objective: Menorrhagia is a common and costly complaint of patients in gynecology. Plantago major L. (P.major) is one of the herbal remedies recommended by Persian medicine for menorrhagia. Materials and methods: In this study, women with menorrhagia who did not have abnormal findings in para-clinical evaluation, were divided into two groups: herbal drug (P.major syrup) and placebo (simple syrup). After one cycle, menstrual blood loss based on Pictorial Blood Loss Assessment Chart (PBAC), menstrual duration, hemoglobin and hematocrit were assessed in both groups. Results: 65 patients completed the study. In the herbal drug group, menstrual blood loss and menstrual duration decreased from 205.5 ± 8.38 to 185.03 ± 12.30 (P< 0.001) and from 8.30 ± 0.85 to 7.68 ± 1.62 (P= 0.003), respectively. Although the difference between groups in terms of blood loss in the baseline was not significant, it became significant after intervention (P< 0.001). Also, after intervention hemoglobin and hematocrit were significantly increased from 11.82 ± 0.39 to 11.99 ± 0.20 and from 35.47 ± 1.18 to 35.69 ± 1.32 resp. (P< 0.001) in herbal drug group, however they were decreased significantly in placebo group. No adverse effects were reported after using the herbal drug. Conclusions: P.major may be a good candidate for further study to be considered as a safe and effective remedy for menorrhagia.

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Section: Discussionmentioning

confidence: 99%

A Double-blind, Randomized Clinical Trial Study of Plantago major l. Syrup on Menorrhagia

2024

J Angiotherapy

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“…Evaluation of the impact on Wistar rats’ local wound healing of an ointment made from a combination of cabbage, pomegranate, and Plantago major ethanolic extract found that on Days 3, 6, 9, and 12, the average percentage of wound healing in the various groups was as follows: In the control group, there were 21.3%, 37.87%, 67.39%, and 77.17%; in the positive control group, there were 24.98%, 34.21%, 70.74%, and 88.55%; and in the ointment group, there were 32.35%, 61.27%, 94.53%, and 99.91%. There was a noticeable difference between the control and main groups ( p < 0.05) [ 98 ]. The topical application of 10% Plantago major leaf extract (PMLE) to infected wounds in rabbits confirmed that PMLE plays a role in promoting healing.…”

Section: Wound-healing Effectsmentioning

confidence: 99%

Antimicrobial and Other Biomedical Properties of Extracts from Plantago major, Plantaginaceae

Zhakipbekov,

Turgumbayeva,

Issayeva

et al. 2023

Pharmaceuticals

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Since ancient times, many scientists and doctors have used various herbs to treat diseases. Conventional drugs often have side effects, and pathogens are becoming resistant to these types of drugs. In such circumstances, the study of traditional medicinal plants is an effective and logical strategy for finding new herbal medicines. One such herb is Plantago major, a perennial plant in the Plantaginaceae family that is found throughout the world. The Plantago major plant has been used as a medicine for the treatment of various diseases. Studies have shown that plant extracts of Plantago major exhibit antimicrobial, antiviral, and anti-inflammatory effects, and have wound-healing properties. This review collects and presents the results of various studies of Plantago major plant extracts with antimicrobial, antiviral, antifungal, anti-inflammatory, and wound-healing properties, which demonstrate a wide range of therapeutic possibilities of Plantago major plant extracts and have a huge potential for use as a medicinal raw material.

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“…In Romanian ethnopediatry, the plant leaves were considered to be beneficial against cough, oliguria, intestinal worms, trauma, and debility [75,86]. Modern studies provided some evidence for its wound healing [164,165], antibronchitis [166], anti-inflammatory [167,168], immunoenhancing [169], and antiparasitic potential [170]. On the contrary, one adult clinical study reported the lack of diuretic effect, which is claimed by various ethnomedical systems [171].…”

Section: Comparison Of Relative Therapeutic Versatility Of Top Medicimentioning

confidence: 99%

Historical ethnobotanical review of medicinal plants used to treat children diseases in Romania (1860s–1970s)

Petran

Dragoș

Gîlcă

2020

J Ethnobiology Ethnomedicine

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Background: Romanian ethnopediatrics has a long history of medicinal plant use. The main objective of the present review was to identify, collect, systematize, and prioritize the available bibliographical data related to medicinal plants traditionally used to treat various pediatric diseases in Romania during the 1860s-1970s. Methods: Information was mainly obtained by manual systematic search in various relevant historical works focused on the traditional use of medicinal plants in Romania (1860s-1970s), found in the Archives of Romanian Academy Library and National Romanian Library. Results: A total of 153 medicinal plants belonging to 52 families were identified as having ethnopediatric significance. The plant traditional indications, targeted body systems, parts used, and way of administration were provided. We have also proposed one index (expressed as percentage) in order to assess the ethnopediatric applicability area of species: ethnopediatric relative therapeutic versatility (ERTV), which was calculated on the basis of the number of distinct uses mentioned for a species. The species identified to have the highest ERTV scores were Dryopteris filix-mas (100%), Gratiola officinalis (85.71%), Allium sativum (71.42%), Eryngium planum (71.42%), Juglans regia (71.42%), Matricaria chamomilla (71.42%), Plantago major (71.42%). Conclusions: The present study exposed for the first time to the international scientific community important ethnopediatric information contained in several local Romanian bibliographical resources that could guide the local and international researchers towards new directions of plant valorization.

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Wound Healing Effect of an Ointment Made From a Mixture of Brassica oleracea var, Punica granatum, and Plantago major L Extracts in Rats

Cited by 4 publications

References 23 publications

A Double-blind, Randomized Clinical Trial Study of Plantago major l. Syrup on Menorrhagia

A Double-blind, Randomized Clinical Trial Study of Plantago major l. Syrup on Menorrhagia

Antimicrobial and Other Biomedical Properties of Extracts from Plantago major, Plantaginaceae

Historical ethnobotanical review of medicinal plants used to treat children diseases in Romania (1860s–1970s)

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