Wound healing effect of bioactive ion released from Mg-smectite

Sasaki, Yu; Sathi, Gulsan Ara; Yamamoto, Osamu

doi:10.1016/j.msec.2017.03.236

Cited by 35 publications

(33 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mg 2+ cations, abundant in both ALI and GR, have demonstrated remarkable properties for tissue regeneration and repair, particularly in the promotion of collagen formation and angiogenesis on skin wounds [ 56 , 87 ]. For this reason, it is conceivable that ALI and GR should perform wound healing effects, as previously remarked.…”

Section: Resultsmentioning

confidence: 99%

“…The maximum exchangeable amount of Mg 2+ from PS9 and G30 corresponded to 17.67 and 37.14 mg/L, respectively ( Table 5 ). Magnesium concentration due to the spring water was 5–12 mg/L, and this proved to be effective during wound healing by Sasaki et al [ 56 ]. Consequently, both PS9 and G30 were considered as potentially effective minerals due to their exchangeable Mg 2+ content.…”

Section: Resultsmentioning

confidence: 99%

“…Biocompatibility of clay minerals such as halloysite, montmorillonite, palygorskite, sepiolite and imogolite have been widely studied [ 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ]. Sasaki et al reported that Mg 2+ and Si 4+ ions released by a synthetic Mg-rich smectite clay mineral can promote collagen formation and angiogenesis on skin wounds [ 56 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Wound Healing Activity of Nanoclay/Spring Water Hydrogels

et al. 2020

View full text Add to dashboard Cite

Background: hydrogels prepared with natural inorganic excipients and spring waters are commonly used in medical hydrology. Design of these clay-based formulations continues to be a field scarcely addressed. Safety and wound healing properties of different fibrous nanoclay/spring water hydrogels were addressed. Methods: in vitro biocompatibility, by means of MTT assay, and wound healing properties were studied. Confocal Laser Scanning Microscopy was used to study the morphology of fibroblasts during the wound healing process. Results: all the ingredients demonstrated to be biocompatible towards fibroblasts. Particularly, the formulation of nanoclays as hydrogels improved biocompatibility with respect to powder samples at the same concentration. Spring waters and hydrogels were even able to promote in vitro fibroblasts motility and, therefore, accelerate wound healing with respect to the control. Conclusion: fibrous nanoclay/spring water hydrogels proved to be skin-biocompatible and to possess a high potential as wound healing formulations. Moreover, these results open new prospects for these ingredients to be used in new therapeutic or cosmetic formulations.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Wound Healing Activity of Nanoclay/Spring Water Hydrogels

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Additionally, collagen can also activate macrophage phagocytosis, enhance the immune function and decrease the infectious rate of wounds (29). Sasaki et al (30) reported that collagen deposition was accelerated and the density of collagen fibers was increased upon application of Mg-smectite in a rat cutaneous wound model. In the present study, the collagen was mainly located in the site of application of mineral smectite granules.…”

Section: Discussionmentioning

confidence: 99%

Investigating the efficacy and safety of mineral smectite granules on wound healing

Wang

Zhao

et al. 2020

Exp Ther Med

View full text Add to dashboard Cite

“…It is well known that adequate concentrations of certain elements, including Ca, Mg, Na and K, in the wound bed are important for enhancing the healing process [ 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ]. Transition metals such as Cu, Zn, Mn, Fe, Ag, and Au (among others) have also been demonstrated to play different biological functions in tissue regeneration, as reviewed by Yang et al [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Correlation between Elemental Composition/Mobility and Skin Cell Proliferation of Fibrous Nanoclay/Spring Water Hydrogels

et al. 2020

View full text Add to dashboard Cite

Inorganic hydrogels formulated with spring waters and clay minerals are used to treat musculoskeletal disorders and skin affections. Their underlying mechanism of action for skin disorders is not clear, although it is usually ascribed to the chemical composition of the formulation. The aim of this study was to assess the composition and in vitro release of elements with potential wound healing effects from hydrogels prepared with two nanoclays and natural spring water. In vitro Franz cell studies were used and the element concentration was measured by inductively coupled plasma techniques. Biocompatibility studies were used to evaluate the potential toxicity of the formulation against fibroblasts. The studied hydrogels released elements with known therapeutic interest in wound healing. The released ratios of some elements, such as Mg:Ca or Zn:Ca, played a significant role in the final therapeutic activity of the formulation. In particular, the proliferative activity of fibroblasts was ascribed to the release of Mn and the Zn:Ca ratio. Moreover, the importance of formulative studies is highlighted, since it is the optimal combination of the correct ingredients that makes a formulation effective.

show abstract

Wound healing effect of bioactive ion released from Mg-smectite

Cited by 35 publications

References 27 publications

Wound Healing Activity of Nanoclay/Spring Water Hydrogels

Wound Healing Activity of Nanoclay/Spring Water Hydrogels

Investigating the efficacy and safety of mineral smectite granules on wound healing

Correlation between Elemental Composition/Mobility and Skin Cell Proliferation of Fibrous Nanoclay/Spring Water Hydrogels

Contact Info

Product

Resources

About