Wound healing effect of Euphorbia hirta linn. (Euphorbiaceae) in alloxan induced diabetic rats

Islam

Evidence-Based Complementary and Alternative Medicine

et al. 2019

Self Cite

The stem bark of Oroxylum indicum (O. indicum) was aimed at testing for anti-inflammatory, antiulcerative, antihyperglycemic, and antidyslipidemic activities. Liver enzyme concentration (SGPT, SGOT) had also been assessed. After being extracted in organic solvent, 3 distinct doses, 100, 200, and 400 mg/kg b.w. (p.o.), were used. For edema formation 0.1 ml carrageenan at a dose of 1% w/v was injected into paw of left hind. It showed a fall of edemas 37.50%, 48.34%, and 55.83% while used doses were 100, 200, and 400 mg/kg b.w. (p.o.) individually. The EtOH extract of O. indicum (50%) and its fractions PET, CLF, EtOAc, and nBUT were studied against ethanol-induced gastric mucosal damage. Only PET and n-BuOH exhibited the highest percentage of protection and were 96% and 99%, respectively, persuaded by ethanol. In OGTT glibenclamide revealed reduction of glucose level to 7.55 ± 0.22 mmol/L from 10.57 ± 0.32 mmol/L after 30 minutes. Antihyperglycemic activities were assessed for 8- and 12-week duration in diabetic rats. Glibenclamide reduced glucose level from 33.50±0.31 to 7.90±0.19 mmol/L in 12 weeks. In 12 and 8 weeks, combination therapy lowered blood glucose level to a normal extent by 79% and 61% individually. In antidyslipidemic activities after 12-week treatment, it revealed simvastatin; MEOI (400 mg/kg b.w.) and combination of both reduced TC level by 44%, 28%, and 48% consequently followed by TG and LDL. In 8-week treatment, HDL levels were increased by 34%, 13%, and 36%, and in 12 weeks increased by 36%, 8%, and 38% consequently. Liver enzyme concentration after 12 weeks of treatment with glibenclamide, 400 mg/kg b.w. (p.o.) of MEOI and combination of both, exhibited the fact that concentration of SGPT showed downturn by 43.23%, 8.01%, and 54.86% and SGOT by 42.40%, 5.31%, and 44.85%. This study remarked that O. indicum has anti-inflammatory, antiulcer, antidiabetic, and antidyslipidemic potentials but has no ameliorative effect on liver enzyme.

Section: Discussionmentioning

confidence: 99%

Ethnopharmacological Inspections of Organic Extract ofOroxylum indicumin Rat Models: A Promising Natural Gift

Islam

Evidence-Based Complementary and Alternative Medicine

et al. 2019

Self Cite

“…E. hirta is belonging to Euphorbiaeceae family and known for its anti-inflammatory, antioxidant, anticancer, antifertility, antimicrobial, antiarthritic, antipyretic, and hepatoprotective potential. [17][18][19][20][21]27] Recent reports also revealed the antidiabetic potential of E. hirta in laboratory animals. [27] A recent study suggests that the flavonoid content present in E. hirta may responsible for its α-amylase and α-glucosidase inhibitory activities.…”

Section: Discussionmentioning

confidence: 99%

“…[15,16] However, E. hirta (Euphorbiaceae), vernacularly called as Dudhi or Dudhanim, has unique combination of possible therapeutic action including antidiabetic, antioxidant, and antiobesity. [17][18][19][20][21] E. hirta extensively found in the Western Ghats and Northeastern banks of Tamil Nadu, India. [22] E. hirta has been proclaimed to hold alkaloids, tannins, saponins, and flavonoids.…”

Section: Original Articlementioning

confidence: 99%

“…[17,[23][24][25][26] Moreover, the presence of numerous chief chemical constituents in E. hirta including quercetrin, polyphenolic flavonoid, and palmitic acid confirmed its antioxidant, anti-inflammatory, hepatoprotective, antiobesity, and antidiabetic potential of this folk medicine. [17][18][19][20][21] The antihyperglycemic activity can block the associated complications, and thus, the herbal extract of E. hirta may produce the pivotal action against DM and associated cardiorenal diseases. Indeed, the therapeutic potential of E. hirta against DM-associated cardiorenal toxicity is still unexplored; hence, this present study has designed to evaluate the antihyperglycemic and associated cardiorenal effect of E. hirta in diabetic rats.…”

Section: Original Articlementioning

confidence: 99%

“…Group 3: Drug per se group received only ethanolic extract of E. hirta leaves (400 mg/kg/p.o) [20,27] throughout the study.…”

Section: Experimental Protocolmentioning

confidence: 99%

See 2 more Smart Citations

Untitled

Katare¹

2018

IJGP

Introduction: Euphorbia hirta is a traditional medicine having unique combination of possible therapeutic action including antidiabetic, antioxidant, and antiobesity. The present study focuses to evaluate the therapeutic potency of ethanolic extract of E. hirta against diabetes mellitus (DM) and associated cardiorenal injury. Materials and Methods: DM was induced by administration of double cycle of repetitive (single injection for 3 alternative days in one cycle) dose of streptozotocin (20 mg/kg/i.p) in high-fat diet animals. Fasting and postprandial blood glucose level, glycated hemoglobin A1c (HbA1c), C-peptide, and plasma insulin were measured to confirm the induction of DM. Serum lipid profile and thiobarbituric acid reactive substances (TBARS) were measured in diabetic animals. Diabetic animals were further evaluated for cardiorenal toxicity after 12 weeks by measuring creatine kinase MB, lactate dehydrogenase, cardiac troponin I, serum creatinine, and blood urea nitrogen, respectively. Structural alteration was observed by histological assessments of pancreatic β-cells and cardiorenal tissues. Results: A significant increased level of fasting and postprandial blood glucose, and HbA1c and decreased level of C-peptide and plasma insulin were observed in diabetic animals. Furthermore, diabetic animals showed abnormal lipid profile (dyslipidemia) and increase serum TBARS (oxidative stress). In addition, the increased level of cardiorenal biomarkers in diabetic animals confirmed the associated abnormalities. The treatment of E. hirta (400 mg/kg/p.o) significantly overcomes the perturbed level of hyperglycemic, lipid profile, oxidative stress, and cardiorenal biomarkers. Histological evaluation of pancreatic and cardiorenal tissue also validates the significant protection of E. hirta against DM and-induced cardiorenal toxicity. Discussion and Conclusion: Thus, E. hirtainduced cardiorenal protection may associate with its antihyperglycemic, antidyslipidemia, and antioxidant potential.

Diabetes and plant‐derived natural products: From ethnopharmacological approaches to their potential for modern drug discovery and development

Jugran

Rawat

Devkota

et al. 2020

Phytotherapy Research

Diabetes is a disease of serious concern faced by the health care industry today. Primary diabetes mellitus and its complications are still costly to manage with modern drugs. Extensive research on the screening of anti‐diabetic agents in past decades established natural products as one of the major potential sources of drug discovery. However, only a few drugs of plant origin have been scientifically validated. Therefore, the development of new anti‐diabetic drugs is of great demand. Hence, natural products could be explored as potential anti‐diabetic drugs. Natural plants derived extracts and molecules like berberine, ginsenosides, curcumin, stevioside, gingerols, capsaicin, catechins, simple phenolic compounds, anthocyanins, resveratrol, genistein and hesperidin obtained from different species are used for curing diabetes and found to possess different action mechanisms. In this review, the importance of medicinal plants and their active constituents for anti‐diabetic agents are described. The present study also emphasized the importance of diabetes control, reduction in its complications and use of the anti‐diabetic agents. The detailed action mechanism of these extracts/compounds for their activities are also described. However, the anti‐diabetic drugs from plant origin require scientific validation through animal and clinical studies to exploit in terms of modern commercial medicines.