Wound Healing Effect of Lippia sidoides and Myracrodruon urundeuva Nanogel

Abstract

This study investigated the effect of a nanogel loaded with Lippia sidoides essential oil and Myracrodruon urundeuva extract (NAA) in an excisional wound healing model in rats. Animals were anesthetized and skin wounds were made using a metal punch. The groups were treated with vehicle, NAA or collagenase gel, for 7, 14 or 21 days and then sacrificed for tissue analysis. Results NAA did not show acute dermal irritation, further significantly reduced (p < 0.05) the final wound area, accelerated the wound contraction and organization of collagen in the group treated for 14 days. Conclusions The data presented here demonstrate the therapeutic potential for the use of nanotechnology associated with medicinal plants and provides evidence that corroborate with the use of L. sidoides and M. urundeuva as healing medicinal plants.