Wound Healing Effect of &lt;b&gt;&lt;i&gt;Lawsonia inermis&lt;/i&gt;&lt;/b&gt;

Rekik, Dorsaf Moalla; Khedir, Sameh Ben; Daoud, A.; Moalla, Kamilia Ksouda; Rebai, T; Sahnoun, Zouheir

doi:10.1159/000501730

Cited by 27 publications

(12 citation statements)

References 33 publications

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“…Over the years, medicinal plants have been used to develop a variety of formulations that combat injuries such as wounds, burns and cuts [ 15 ]. Several ethno-medicinal plants have been used for medicinal applications thanks to their wide biological activities and medicinal applications due to counteracting oxidative stress potential, lesser costs and high safety margins [ 16 , 17 , 18 ]. Plant extracts are known to exhibit many pharmacological properties (anti-hyperlipidemic, anti-proliferative, and immunomodulatory, etc.)…”

Section: Introductionmentioning

confidence: 99%

“…It was investigated in terms of its potential antioxidant components such as flavonoids and polyphenols [ 10 , 11 , 21 ]. Previous studies reported that it is a potential source of anticancer and antioxidant molecules [ 16 ]. It is a very rich source of valuable compounds, such as polyphenols, vitamins, flavonoids, carotenoids and carbohydrates [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

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The Role of Allium subhirsutum L. in the Attenuation of Dermal Wounds by Modulating Oxidative Stress and Inflammation in Wistar Albino Rats

et al. 2021

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In our study, Allium subhirsutum L. (AS) was investigated to assess its phenolic profile and bioactive molecules including flavonoids and organosulfur compounds. The antioxidant potential of AS and wound healing activity were addressed using skin wound healing and oxidative stress and inflammation marker estimation in rat models. Phytochemical and antiradical activities of AS extract (ASE) and oil (ASO) were studied. The rats were randomly assigned to four groups: group I served as a control and was treated with simple ointment base, group II was treated with ASE ointment, group III was treated with ASO ointment and group IV (reference group; Ref) was treated with a reference drug “Cytolcentella® cream”. Phytochemical screening showed that total phenols (215 ± 3.5 mg GAE/g) and flavonoids (172.4 ± 3.1 mg QE/g) were higher in the ASO than the ASE group. The results of the antioxidant properties showed that ASO exhibited the highest DPPH free radical scavenging potential (IC50 = 0.136 ± 0.07 mg/mL), FRAP test (IC50 = 0.013 ± 0.006 mg/mL), ABTS test (IC50 = 0.52 ± 0.03 mg/mL) and total antioxidant capacity (IC50 = 0.34 ± 0.06 mg/mL). In the wound healing study, topical application of ASO performed the fastest wound-repairing process estimated by a chromatic study, percentage wound closure, fibrinogen level and oxidative damage status, as compared to ASE, the Cytolcentella reference drug and the untreated rats. The use of AS extract and oil were also associated with the attenuation of oxidative stress damage in the wound-healing treated rats. Overall, the results provided that AS, particularly ASO, has a potential medicinal value to act as effective skin wound healing agent.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Role of Allium subhirsutum L. in the Attenuation of Dermal Wounds by Modulating Oxidative Stress and Inflammation in Wistar Albino Rats

et al. 2021

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“…Several natural ingredients in dermocosmetic products have shown promising wound care choices [13,14]. One of the most interesting substances is snail mucus secretion, which is currently gaining popularity in the world of cosmetics and cosmeceuticals [15].…”

Section: Introductionmentioning

confidence: 99%

Snail Soothing and Repairing Cream Improves Skin Hydration after Ablative Fractional CO2 Laser: A Split-Face Randomized Double-Blinded Placebo-Controlled Trial

Theerawattanawit¹,

Promvaranon²,

Rerknimitr³

et al. 2021

Skin Pharmacol Physiol

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Background: Ablative fractional carbon dioxide laser (AFCO2) resurfacing causes transient skin barrier disruption characterized by decreased skin hydration and increased transepidermal water loss (TEWL). Snail Soothing and Repairing (SSR) cream, containing several glycoproteins with potential antimicrobial and antioxidant effects, may benefit skin hydration promotion after the laser treatment. Objective: To evaluate the efficacy and safety of SSR cream in skin hydration promotion after AFCO2 resurfacing. Method: The study was a double-blinded, split-face, placebo-controlled trial in participants aged 18–50 years with atrophic acne scars on both cheeks. After AFCO2 resurfacing, participants applied the product or placebo on either cheek twice daily for 14 days. Corneometry, TEWL, colorimetry, and clinical assessments (edema, erythema, crusting, pruritus, and tightness score) were evaluated at baseline, day 7, and day 14 after AFCO2 resurfacing. Results: From 22 participants in the study, the SSR cream-treated sides showed significantly higher corneometry levels than placebo-treated sides at day 14 (p = 0.033), while TEWL and colorimetry levels were not different at any study visits. Pruritus and tightness scores of the SSR side were lower, but not significant, than the placebo. Other clinical assessments (edema, erythema, and crusting) showed similar results. No significant adverse events took place. Conclusion: The SSR cream significantly improved skin hydration, highlighting skin barrier restoration after AFCO2 resurfacing, with a good safety profile.

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“…This comes in agreement with previous studies that described antibacterial properties of L. inermis and L. plantarum . 14 , 23 , 24 The MIC of L. plantarum could be decreased from 13mg/mL to 2 mg/mL when combined with L. inermis indicating a synergistic effect in case of L. plantarum with FIC (fraction inhibitory concentration) =0.5 . On the other side the combination had an antagonistic effect on L. inermis with MIC increased from 0.7 to 13 mg/mL with FIC (fraction inhibitory concentration) =9.…”

Section: Discussionmentioning

confidence: 95%

Synergistic Antimicrobial Effect of Lactiplantibacillus plantarum and Lawsonia inermis Against Staphylococcus aureus

Elebeedy¹,

Ghanem²,

El‐Sayed³

et al. 2022

IDR

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Purpose The developed resistance of pathogenic microorganisms towards the currently used antimicrobial agents requires the fast search for newer potent antimicrobials. One of the most important ways to combat the previously mentioned disaster is the use of natural alternatives like medicinal plants. Our study aimed to estimate the anti-inflammatory property, and antibacterial effects of probiotics Lactiplantibacillus plantarum and ethanol extracts of Lawsonia inermis leaves against Staphylococcus aureus when they were used separately or collectively as synergism. Material and Methods Experimentally induced infected wound model in mice was created and divided into 10 groups then treated for two days by L. plantarum and L. inermis individually or in combination, followed by biochemical assays. The antibacterial, anti-inflammatory, and wound healing activity were evaluated through histopathological sections taken before and after treatment. Results Our results revealed that L. plantarum and L. inermis mixture could inhibit growth of S. aureus and decrease the minimal inhibitory concentration (MIC) of L. plantarum to 2 mg/mL. The mixture decreased level of both interleukin 6 (IL-6) and interferon-alpha (TNF-α) to a level near the normal uninfected group. Histopathological study showed that animals treated with both L. plantarum and L. inermis had achieved almost 90% healing. Conclusion These results suggest that L. plantarum and L. inermis mixture has synergistic effect on healing of infected wound.

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Wound Healing Effect of <b><i>Lawsonia inermis</i></b>

Cited by 27 publications

References 33 publications

The Role of Allium subhirsutum L. in the Attenuation of Dermal Wounds by Modulating Oxidative Stress and Inflammation in Wistar Albino Rats

The Role of Allium subhirsutum L. in the Attenuation of Dermal Wounds by Modulating Oxidative Stress and Inflammation in Wistar Albino Rats

Snail Soothing and Repairing Cream Improves Skin Hydration after Ablative Fractional CO<sub>2</sub> Laser: A Split-Face Randomized Double-Blinded Placebo-Controlled Trial

Synergistic Antimicrobial Effect of Lactiplantibacillus plantarum and Lawsonia inermis Against Staphylococcus aureus

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