Wound Healing Effect of Naringin Loaded Gel in Alloxan Induced Diabetic Mice

Okur, Mehmet Evren; Sakul, Ayse Arzu; Ayla, Şule; Karadağ, Ayşe Esra; Şenyüz, Cemre Şahin; Batur, Şebnem; Daylan, Benay; Özdemir, Ekrem Musa; Yücelik, Şaziye Sezin; Sipahi, Hande; Aydın, Ahmet

doi:10.33483/jfpau.742224

Cited by 4 publications

(3 citation statements)

References 32 publications

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“…Naringin, is a natural flavonoid found on citrus fruits peel especially on grapefruit. Naringin is responsible for the bitterness of the citrus fruits; despite its sour taste, naringin has been studied for its proliferation of human mesenchymal stem cells [4], anti-inflammatory action [5], angiogenesis [6], wound healing [7,8] and possible antinociceptive central mechanism [9]. Naringin, as drug has been classified in class II of Biopharmaceutical Classification System due to its low solubility and permeability.…”

Section: Introductionmentioning

confidence: 99%

In situ gels loaded with naringin as ocular drug delivery carriers; development and preliminary characterization

SIAFAKA,

YAĞCILAR,

GÜVEN

et al. 2024

jrp

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Ocular drug delivery of any molecule is quite complex and challenging due to the ophthalmic anatomy. The current ocular formulations such as drops, gels or ointments cannot deliver the active molecules efficiently, therefore newer dosage forms are being developed. In situ gels which are in the liquid state in room temperature or in certain pH but transform to gels when instilled onto the eye belongs to such innovative dosage forms. Herein, the fabrication of in situ gels for naringin ocular delivery is presented since there are very few studies examining the use of naringin as an active molecule for eye delivery. Naringin which is hydrolyzed in naringenin, is a flavonoid glucoside found on citrus fruits and has been studied as antioxidant and anti-inflammatory agent or potent antimicrobial agent. The naringin loaded in situ gels developed via cold method using Poloxamer 407, sodium alginate and hydroxypropyl methylcellulose E5. The temperature-responsive in situ gels were characterized for clarity, sol-gel transition temperature, gelling capacity, pH and viscosity. All the results were of desirable limits. Furthermore, in vitro drug release demonstrated that the in situ gels showed sustained pattern Antimicrobial studies indicated specific antimicrobial potency against Enterococcus faecalis. Future studies will involve in vivo studies and ocular irritation analysis.

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Section: Introductionmentioning

confidence: 99%

In situ gels loaded with naringin as ocular drug delivery carriers; development and preliminary characterization

SIAFAKA,

YAĞCILAR,

GÜVEN

et al. 2024

jrp

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“…Одним из наиболее распространенных классов биологически активных веществ (БАВ) растительного происхождения являются флавоноиды, которые, по результатам различных клинических исследований, обладают широким спектром терапевтического действия, в том числе ранозаживляющего [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21].…”

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“…В частности, выполняются исследования по изучению местного применения флавоноидов, их влияния на лечение атопического дерматита, псориаза, инфекционных заболеваний кожи [5][6][7], ожогов, вызванных УФ-радиацией [8][9][10][11]. Установлено, что флавоноиды оказывают ранозаживляющее действие после термических [12][13][14][15] и химических ожогов [16,17], уменьшают фиброзное образование ткани [11,18], а также усиливают регенерационные процессы в патологических условиях, например при сахарном диабете [19][20][21].…”

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Wound-healing effect of the gel substance based on the flavonoids complex from extracts of the everlasting(<i>Helichrysum arenarium</i> L.) and the littlewale (<i>Lithospermum officinale</i> L.)

Adamtsevich

Feskova

Леонтьев

et al. 2022

Vescì Akademìì navuk Belarusì. Seryâ biâlagičnyh navuk

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The study of wound-healing effect of the gel substances with 2 and 4 % (w/w) concentrations of the dry extracts of the everlasting flowers and of the littlewale leaves in the ratio 1:1 were carried out.It was found that the skin application of the studied gel substances promoted the formation of the structural and functional regenerate in the area of the wound defect. The studied gel contributed to the significant reduction of the healing duration of the full-thickness linear wounds in rats compared to the control group of animals (without treatment) and to the group of animals that received treatment with the reference listed drug. The use of the studied gels, regardless of the content of the plant extracts in them (2 or 4 % (w/w)), was not accompanied by toxic effects.

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Promising Phytoconstituents in Diabetes-related Wounds: Mechanistic Insights and Implications

Sultana,

Borgohain,

Rayaji

et al. 2025

CDR

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Background: The onset of diabetes mellitus (DM), a metabolic disorder characterized by high blood glucose levels and disrupted glucose metabolism, results in 20% of people with diabetes suffering from diabetes-related wounds worldwide. A minor wound, such as a cut or abrasion, can lead to infections and complications in diabetic patients. We must understand the mechanism/s contributing to this delayed wound healing to develop effective prevention strategies. The potential benefits of bioactive phytochemicals for diabetic wound healing have been reported in numerous studies. Method: A bioactive compound may have multiple actions, including antioxidants, antiinflammatory, antimicrobial, and angiogenesis. Compounds derived from these plants have shown promising results in wound healing, inflammation reduction, collagen synthesis, and neovascularization improvement. Results: Consequently, this review provides an update to our understanding of how phytoconstituents promote wound healing in diabetics. A thorough literature review was conducted on diabetes, wound healing, and phytoconstituents for this study. Only English publications until June 2023 were included in the search, which used multiple search engines and the main keywords. Summing up, phytochemical-based interventions might improve the quality of life for diabetics by improving wound healing. Conclusion: However, to fully understand the efficacy and safety of these phytochemicals in managing diabetic wounds, more research and clinical trials are needed.

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Wound Healing Effect of Naringin Loaded Gel in Alloxan Induced Diabetic Mice

Cited by 4 publications

References 32 publications

In situ gels loaded with naringin as ocular drug delivery carriers; development and preliminary characterization

In situ gels loaded with naringin as ocular drug delivery carriers; development and preliminary characterization

Wound-healing effect of the gel substance based on the flavonoids complex from extracts of the everlasting(<i>Helichrysum arenarium</i> L.) and the littlewale (<i>Lithospermum officinale</i> L.)

Promising Phytoconstituents in Diabetes-related Wounds: Mechanistic Insights and Implications

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