Wound healing effects of collagen-laminin dermal matrix impregnated with resveratrol loaded hyaluronic acid-DPPC microparticles in diabetic rats

Gökçe, Evren; Tanrıverdi, Sakine Tuncay; Eroğlu, İpek; Tsapis, Nicolas; Gökçe, Göksel; Tekmen, Işıl; Özer, Özgen

doi:10.1016/j.ejpb.2017.04.027

Cited by 82 publications

(55 citation statements)

References 31 publications

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“…[45][46][47] Resveratrol is a natural polyphenolic compound derived from grapes which also exhibits anti-bacterial properties and has shown to enhance tissue regeneration in diabetic rats. 37,[48][49][50] Considering the high potential of antioxidant agents in modulating different aspects of the healing process, we added two antioxidant compounds, i.e. curcumin and t-resveratrol, to the alginate hydrogel.…”

Section: Resultsmentioning

confidence: 99%

Breathable hydrogel dressings containing natural antioxidants for management of skin disorders

et al. 2019

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Traditional wound dressings are not effective enough to regulate the moisture content and remove excessive exudate from the environment. Wet wound dressings formed from hydrogels such as alginate are widely used in clinical practice for treatment of skin disorders. Here, we functionalize alginate dressings with natural antioxidants such as curcumin and t-resveratrol to render them both anti-inflammatory and antibacterial. The hydrogel maintains excellent mechanical properties and oxygen permeability over time. The release rate of the compounds from the hydrogels is assessed and their impact on bacterial and cellular growth is evaluated. The antioxidant compounds act as bactericidal agents and improve cell viability. The optimal concentration of active compounds in the engineered alginate-based dressings is determined.

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Section: Resultsmentioning

confidence: 99%

Breathable hydrogel dressings containing natural antioxidants for management of skin disorders

et al. 2019

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“…No benefit [126] Abbreviations: ND, not determined; AQP3, aquaporin 3; SOD, superoxide dismutase; MDA, malondialdehyde; GSH-Px, glutathione peroxidase; GST, glutathione S-transferase; GSH, reduced glutathione; NQO, NAD(P)H:quinone oxidoreductase; ROS: reactive oxygen species; CYP1A1, cytochrome P540 family 1 subfamily A member 1; IKKα, ΙκB kinase α; CYP1B1, cytochrome P540 family 1 subfamily B member 1; COX, cyclooxygenase; ODC, ornithine decarboxylase; NRF2, nuclear factor erythroid 2-related factor 2; ERK: extracellular signal-regulated kinase; MAPK, mitogen-activated protein kinase; JNK, c-Jun NH2-terminal kinase; TPA, 12-O-tetradecanoyl13-phorbol acetate; DNFB, 2,4-dinitro-1-fluorobenzene; NOS, nitric oxide synthase; VEGF, vascular endothelial growth factor; AMPK, adenosine monophosphate-activated protein kinase. 8 Evidence-Based Complementary and Alternative Medicine antioxidants have been utilized to prevent and treat certain disorders [140][141][142].…”

Section: Modelsmentioning

confidence: 99%

“…Huang et al also reported that a single application of resveratrol accelerated cutaneous wound healing in diabetic mice [125]. However, other studies have shown little or no benefit of resveratrol in wound healing following a single application in diabetic rats [126]. us, the potential benefits of resveratrol for wound healing in diabetic models still need to be validated.…”

Section: Anti-inflammationmentioning

confidence: 99%

Role of Resveratrol in Regulating Cutaneous Functions

Wen

Zhang

Yang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Protective role of the skin is against external insults and maintenance of electrolyte homeostasis of the body. Cutaneous dysfunction can account for the development of both cutaneous and systemic disorders. Thus, improvements in cutaneous functions can benefit a number of extracutaneous and cutaneous functions. Resveratrol, a natural ingredient, displays multiple benefits for various systems/organs, including the skin. The benefits of resveratrol for cutaneous functions include stimulation of keratinocyte differentiation and antimicrobial peptide expression, inhibition of keratinocyte proliferation and cutaneous inflammation, UV protection, anticancer, antiaging, and inhibition of melanogenesis. The mechanisms of action of resveratrol include activation of sirtuin 1 and nuclear factor erythroid 2-related factor 2, and inhibition of mitogen-activated protein kinase signaling. Evidence suggests that topical resveratrol could be a valuable alternative not only for daily skin care, but also for the prevention and treatment of various cutaneous disorders. This review summarizes the benefits of resveratrol for cutaneous functions.

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“…Przykłady mikro i nanonośników resweratrolu. Polimerowe membrany kolagen, laminina, chitozan in vitro oraz in vivo na szczurach [26,27] 24 h inkubacji, w teście MTS największą przeżywalność komórek gwarantowało zastosowanie liposomów z resweratrolem. Wykazano, że dzięki takiemu rozwiązaniu zwiększa się skuteczność resweratrolu w zapobieganiu i leczeniu uszkodzeń skóry związanej z nadmierną ekspozycją na promieniowanie UV.…”

Section: Charakterystyka Resweratroluunclassified

“…Gokce i wsp. [26] inkorporowali mikrocząstki resweratrolu do matrycy złożonej z kolagenu i lamininy, będących naturalnymi składnikami macierzy pozakomórkowej. Proces technologiczny był kilkuetapowy.…”

Section: Materiały Opatrunkoweunclassified

New Technological Solutions in the Aspect of Topical and Oral Administration of Resveratrol

Górska¹,

Niwiński²,

Jachowicz³

2019

Farm Pol.

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Wound healing effects of collagen-laminin dermal matrix impregnated with resveratrol loaded hyaluronic acid-DPPC microparticles in diabetic rats

Cited by 82 publications

References 31 publications

Breathable hydrogel dressings containing natural antioxidants for management of skin disorders

Breathable hydrogel dressings containing natural antioxidants for management of skin disorders

Role of Resveratrol in Regulating Cutaneous Functions

New Technological Solutions in the Aspect of Topical and Oral Administration of Resveratrol

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