Wound healing in the fetal lamb

Burrington, John D.

doi:10.1016/0022-3468(71)90373-3

Cited by 157 publications

(81 citation statements)

References 8 publications

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“…Since then, similar observations have been reported in other mammals, including sheep, mice, rats, and humans (Somasundaram and Prathap 1970;Burrington 1971;Sopher 1972;Rowlatt 1979;Hallock 1985). In Somasundaram and Prathap's study (Hallock 1985), a 0.5-cm disc of skin of either newborn or fetal (14 -25 d after gestation) rabbits was excised.…”

Section: Scarless Wound-healing Process In Mammalsmentioning

confidence: 86%

Wound Healing and Skin Regeneration

Takeo

Lee

Ito

2015

Cold Spring Harbor Perspectives in Medicine

514

319

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The skin is a complex organ consisting of the epidermis, dermis, and skin appendages, including the hair follicle and sebaceous gland. Wound healing in adult mammals results in scar formation without any skin appendages. Studies have reported remarkable examples of scarless healing in fetal skin and appendage regeneration in adult skin following the infliction of large wounds. The models used in these studies have offered a new platform for investigations of the cellular and molecular mechanisms underlying wound healing and skin regeneration in mammals. In this article, we will focus on the contribution of skin appendages to wound healing and, conversely, skin appendage regeneration following injuries.

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Section: Scarless Wound-healing Process In Mammalsmentioning

confidence: 86%

Wound Healing and Skin Regeneration

Takeo

Lee

Ito

2015

Cold Spring Harbor Perspectives in Medicine

514

319

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“…In contrast to adult (postnatal) wound healing, fetal skin wounds heal rapidly with minimal inflammation and no scar formation (Burrington 1971;Krummel et al 1987;Siebert et al 1990). Multiple studies have pointed out the biochemical, physiological and mechanical differences (reviews by Yannas 2005;Wilgus 2007;Hantash et al 2008;Buchanan et al 2009) observed between fetal and adult skin wound healing, but as yet the critical factors determining the disparity in healing outcome have yet to be identified.…”

Section: Introductionmentioning

confidence: 99%

Cloning and expression of rabbit CCT subunits eta and beta in healing cutaneous wounds

Satish

Johnson

Abdulally

et al. 2010

Cell Stress and Chaperones

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We have previously identified the CCT subunit eta as specifically reduced in healing fetal skin wounds by differential display, and observed that this reduction is not seen with any other CCT subunit. We now report the cloning and characterization of the cDNAs for rabbit CCT-eta and its closest evolutionary homolog, CCT-beta. Quantitative examination of CCT-eta and -beta message expression in healing fetal and adult wounds at 12 h post-injury confirms that CCT-eta mRNA is decreased in fetal wound tissues, but actually elevated in adult wound tissues. CCT-beta mRNA, in contrast, remains unchanged in both fetal and adult wound tissues. CCT-eta mRNA remains persistently elevated in healing adult wounds for 28 days following injury, whereas CCT-beta mRNA remains invariant throughout. CCT-eta protein is similarly increased, whereas CCT-beta protein remains unchanged. -smooth muscle actin ( -SMA), a recognized substrate of CCT known to be important in integumentary wound healing, was also measured over the course of wound healing, and both mRNA and protein levels were elevated throughout the 28 days.

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“…The existence of scarless healing in the fetus was first observed in 1971, 1 but the transition from scarless to scar-forming wound healing was first demonstrated in fetal lambs in 1990. 18 This transition was further demonstrated in fetal rhesus monkeys in 1993.…”

Section: Scarless Wound Healingmentioning

confidence: 99%

Mechanical Forces in Cutaneous Wound Healing: Emerging Therapies to Minimize Scar Formation

Barnes

Marshall

Leavitt

et al. 2018

Advances in Wound Care

171

131

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Significance: Excessive scarring is major clinical and financial burden in the United States. Improved therapies are necessary to reduce scarring, especially in patients affected by hypertrophic and keloid scars. Recent Advances: Advances in our understanding of mechanical forces in the wound environment enable us to target mechanical forces to minimize scar formation. Fetal wounds experience much lower resting stress when compared with adult wounds, and they heal without scars. Therapies that modulate mechanical forces in the wound environment are able to reduce scar size. Critical Issues: Increased mechanical stresses in the wound environment induce hypertrophic scarring via activation of mechanotransduction pathways. Mechanical stimulation modulates integrin, Wingless-type, protein kinase B, and focal adhesion kinase, resulting in cell proliferation and, ultimately, fibrosis. Therefore, the development of therapies that reduce mechanical forces in the wound environment would decrease the risk of developing excessive scars. Future Directions: The development of novel mechanotherapies is necessary to minimize scar formation and advance adult wound healing toward the scarless ideal. Mechanotransduction pathways are potential targets to reduce excessive scar formation, and thus, continued studies on therapies that utilize mechanical offloading and mechanomodulation are needed.

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Wound healing in the fetal lamb

Cited by 157 publications

References 8 publications

Wound Healing and Skin Regeneration

Wound Healing and Skin Regeneration

Cloning and expression of rabbit CCT subunits eta and beta in healing cutaneous wounds

Mechanical Forces in Cutaneous Wound Healing: Emerging Therapies to Minimize Scar Formation

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