Wound healing in urology

Ninan, Neethu; Thomas, Sabu; Grohens, Yves

doi:10.1016/j.addr.2014.12.002

Cited by 36 publications

(24 citation statements)

References 104 publications

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“…20 Immediately after injury, hemostasis takes place in which excessive loss of blood through the damaged blood vessel is prevented. 21 Vasoconstriction occurs and platelets cluster together at the site of wound to form a clot by the conversion of a plasma glycoprotein like fibrinogen to a non-globular protein called as fibrin by a serine protease like thrombin. These aggregated platelets secrete several growth factors and cytokines like transforming growth factor-b (TGF -b), chemo attractant protein which allows passage of neutrophil and monocytes to the wound site, to render protection from bacterial infection.…”

Section: Phases Of Wound Healingmentioning

confidence: 99%

Natural Polymer/Inorganic Material Based Hybrid Scaffolds for Skin Wound Healing

et al. 2015

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Dermal tissue engineering focuses on the restoration of diseased and damaged tissues by using a combination of cells, biomaterials, and bioactive molecules. Inorganic substances like zeolites, clay, mesoporous silica, metals, and metal oxides are advanced materials used in wound healing research. They can improve the structural stability and bioactivity of bio polymeric scaffolds. Zeolites, clays, and mesoporous silica act as suitable carriers for drug delivery and when incorporated within scaffolds, serve as ideal matrices for promoting skin regeneration. This review focuses on various natural polymers/inorganic materials based composite scaffolds used for skin tissue engineering, highlighting their synthesis routes and mode of action by which wound healing is enhanced. Among the different inorganic materials used, the role of zeolites incorporated biocomposites for promoting blood coagulation, antibacterial effect; oxygen delivery to cells and wound healing are discussed in detail. The article thus includes recent attempts to explore the hidden potential of inorganic materials in dermal tissue engineering.

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Section: Phases Of Wound Healingmentioning

confidence: 99%

Natural Polymer/Inorganic Material Based Hybrid Scaffolds for Skin Wound Healing

et al. 2015

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“…The material to be used should have physical features including elasticity, resistance and flexibility and must adjust tightly to the tissue surface. The chosen dressing must present minimal adverse reactions when in contact with living tissues or organic fluids and must be easily removable (8, 9). …”

Section: Introductionmentioning

confidence: 99%

A wet dressing for male genital surgery: A phase II clinical trial

et al. 2016

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Purpose:This study was to confirm the safety and efficacy of BC dressing when used in surgical male wound healing at the urogenital area.Methods:Open, non-controlled clinical study of phase II. A total of 141 patients, among those children, adolescents and adults with hypospadias (112), epispadias (04), phymosis (13) and Peyronie's disease (12) that had a BC dressing applied over the operated area after surgery. A written informed consent was obtained from all participants. Study exclusion criteria were patients with other alternative treatment indications due to the severity, extent of the injury or the underlying disease. The outcomes evaluated were efficacy, safe and complete healing. The costs were discussed.Results:In 68% patients, the BC dressing fell off spontaneously. The BC was removed without complications in 13% of patients at the outpatient clinic during the follow-up visit and 17% not reported the time of removal. In 3% of the cases, the dressing fell off early. Complete healing was observed between 8th and 10th days after surgery. The BC dressings have shown a good tolerance by all the patients and there were no reports of serious adverse events.Conclusion:The bacterial cellulose dressings have shown efficacy, safety and that can be considered as a satisfactory alternative for postoperative wound healing in urogenital area and with low cost.

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“…Urethral wound healing after injury is a complex biological process . The application of MSCs has proved to be able to improve wound healing via cell differentiation and paracrine effects.…”

Section: Discussionmentioning

confidence: 99%

“…Urethral wound healing after injury is a complex biological process. 5 The application of MSCs has proved to be able to improve wound healing via cell differentiation and paracrine effects. However, unfavourable microenvironment factors caused multiple impairments in cellular responses would hinder wound healing process.…”

Section: Discussionmentioning

confidence: 99%

“…Normally, the performance of current surgical repair techniques such as urethroplasty or direct end‐to‐end anastomosis is often accompanied by subsequent tissue fibrosis, poor vascularization and chronic inflammation, which might eventually lead to secondary stricture formation . The impaired wound healing after urethroplasty is proved to be a complex biological process, during which the inflammation, tissue formation including angiogenesis and granulation, and tissue remodelling play vital roles . Thus multiple impairments of cellular responses contributed to non‐healing wounds during the wound healing process after urethroplasty, which make it a more complicated issue for success management of urethral stricture disease.…”

Section: Introductionmentioning

confidence: 99%

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miR‐21 modification enhances the performance of adipose tissue‐derived mesenchymal stem cells for counteracting urethral stricture formation

Feng

Chen

et al. 2018

J Cellular Molecular Medi

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The treatment of complicated long segment strictures remains to a challenge, and the substitution urethroplasty treatment is often accompanied by subsequent tissue fibrosis and secondary stricture formation. In situ injection of human adipose tissue‐derived stem cells (hADSC) could potential be applied for prevention of urethral fibrosis, but the cells transplantation alone may be insufficient because of the complicated histopathological micro‐environmental changes in the injury site. This study investigated whether miR‐21 modification can improve the therapeutic efficacy of ADSCs against urethral fibrosis to limit urethral stricture recurrence. MiR‐21‐modified ADSCs (miR‐21) were constructed via lentivirus‐mediated transfer of pre‐miR‐21 and GFP reporter gene. In vitro results suggested that miR‐21 modification can increase the angiogenesis genes expression of ADSCs and enhance its anti‐oxidative effects against reactive oxygen species (ROS) damage. In vivo results showed that miR‐21 modification contributes to increased urodynamic parameters and better formation of the epithelium and the muscle layer as compared to ADSCs transplantation alone groups. The results demonstrated that miR‐21 modification in ADSCs could improve urethral wound healing microenvironment, enhance stem cell survival through ROS scavenging and promote the neovascularization via regulating angiogenic genes expression, which eventually increase the ADSCs' therapeutic potential for urethral wound healing.

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Wound healing in urology

Cited by 36 publications

References 104 publications

Natural Polymer/Inorganic Material Based Hybrid Scaffolds for Skin Wound Healing

Natural Polymer/Inorganic Material Based Hybrid Scaffolds for Skin Wound Healing

A wet dressing for male genital surgery: A phase II clinical trial

miR‐21 modification enhances the performance of adipose tissue‐derived mesenchymal stem cells for counteracting urethral stricture formation

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