Wound Healing: Methods and Protocols

Ševeljević-Jaran, D.

doi:10.1007/s00011-003-1192-6

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“…Breaking strength or tensile strength is an important tool for evaluating wound healing effects of drugs 12 . Matzsch 2 showed that the breaking strength of colonic anastomosis in rats significantly increased after cessation of LMWH administration.…”

Section: Discussionmentioning

confidence: 99%

The effect of prophylactic dose of a low molecular weight heparin on skin wound healing of rats

et al. 2009

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Purpose:To investigate the effect of prophylactic dose of a low molecular weight heparin, enoxaparin, on skin wound healing of rats. Methods: Forty rats were used for the study. Rats were randomly assigned to two equal groups. Experimental group received prophylactic dose of enoxaparin. Physiologic saline was administered to the control group. Parameters of wound healing of experimental and control groups were compared. For comparison of the groups in terms of fibrosis, vascularization, inflammation, epithelization, and tensile strength test (Newton). Mann-Whitney-U test was used because variables were categorical data (fibrosis, vascularization, inflammation and epithelization). Differences between groups were analyzed with independent samples t-test (tensile strength). Significance was set at p<0.05. Results: Skin wound of the experimental group presented tensile strength significantly decreased (p<0.001), histopathologic examination revealed a significant (p<0.001) delayed epithelization and decreased in fibrosis, vascularization, inflammation (p<0.001) in the experimental group. Conclusion: Enoxaparin delay wound healing by decreased inflammatory cells, fibroblast contents and their products (growth factors), and by promoted hemorrhage.

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Section: Discussionmentioning

confidence: 99%