Wound healing performance of PCL/chitosan based electrospun nanofiber electrosprayed with curcumin loaded chitosan nanoparticles

Fahimirad, Shohreh; Satei, Parastu; Ghaznavi‐Rad, Ehsanollah; Moslehi, Mohsen; Ganji, Ali

doi:10.1016/j.carbpol.2021.117640

Cited by 228 publications

(105 citation statements)

References 55 publications

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“…Furthermore, by binding to red blood cells CS causes rapid blood clotting. CS is also utilized to improve the stability of the drugs by producing CS NPs and resulting in drug accumulation increment [206].…”

Section: Wound Healingmentioning

confidence: 99%

“…Fahimirad et al [206] fabricated the electrospun poly(ε-caprolactone) (PCL)/Chitosan (CS)/curcumin (CUR) nanofiber (CUR-PCL/CS NFs) with CUR loaded CS nano-encapsulated particles (CUR-CS NPs). The electrospraying of CUR-CS NPs on the surface of CUR-PCL/CS NFs resulted in enhanced antibacterial, antioxidant, cell proliferation efficiencies, and higher swelling and water vapor transition rates.…”

Section: Wound Healingmentioning

confidence: 99%

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Advances in Chitosan-Based Nanoparticles for Drug Delivery

Mikušová

Mikuš

2021

IJMS

295

120

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Nanoparticles (NPs) have an outstanding position in pharmaceutical, biological, and medical disciplines. Polymeric NPs based on chitosan (CS) can act as excellent drug carriers because of some intrinsic beneficial properties including biocompatibility, biodegradability, non-toxicity, bioactivity, easy preparation, and targeting specificity. Drug transport and release from CS-based particulate systems depend on the extent of cross-linking, morphology, size, and density of the particulate system, as well as physicochemical properties of the drug. All these aspects have to be considered when developing new CS-based NPs as potential drug delivery systems. This comprehensive review is summarizing and discussing recent advances in CS-based NPs being developed and examined for drug delivery. From this point of view, an enhancement of CS properties by its modification is presented. An enhancement in drug delivery by CS NPs is discussed in detail focusing on (i) a brief summarization of basic characteristics of CS NPs, (ii) a categorization of preparation procedures used for CS NPs involving also recent improvements in production schemes of conventional as well as novel CS NPs, (iii) a categorization and evaluation of CS-based-nanocomposites involving their production schemes with organic polymers and inorganic material, and (iv) very recent implementations of CS NPs and nanocomposites in drug delivery.

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Section: Wound Healingmentioning

confidence: 99%

Section: Wound Healingmentioning

confidence: 99%

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Mikušová

Mikuš

2021

IJMS

295

120

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“…Electrospinning is a simple, effective, and versatile method to yield fibrous structures with fiber diameters ranging between few nanometers to lower than one micrometer, a size that is difficult to attain using conventional spinning techniques. Compared to other techniques used for nanofiber production, such as phase separation, self-assembly, template synthesis, mechanical drawing, melt blowing, hydrothermal processing, centrifugal force spinning, and bicomponent extrusion, this method is the most effective in producing nanofibers with a homogeneous structure [ 5 , 172 , 173 ], thus being the method of choice for this particular purpose [ 169 , 171 ]. A polymeric solution is injected through a needle and directed at a collector (frequently a conductive aluminum plate, which generates nonwoven structures).…”

Section: Biomedical Applications: Fiber-based Systemsmentioning

confidence: 99%

“…Co-spun poly(ε−caprolactone) (PCL)/CS/curcumin nanofibers were fabricated by electrospinning, yielding nanofibers of ≈100 nm in diameter [ 172 ]. Then, curcumin-loaded electrostatically self-assembled CS/TPP NPs (via ionic gelation creating round-shaped NPs, with d ≈ 32 nm) were electrosprayed onto the surface of the previously prepared nanofibers, to improve the sustained release of curcumin at the wound site.…”

Section: Biomedical Applications: Fiber-based Systemsmentioning

confidence: 99%

“…In vivo examination showed significant improvement of wound healing in MRSA-infected wounds. Wound healing [ 172 ] PCL/GN Electrospinning - Dispersion (solubilization until NP homogenization was reached within the polymeric solution) CS/TPP Curcumin Ionic gelation - Improved biocompatibility and wound healing abilities in a full-thickness excisional animal model. Cell attachment and proliferation was enhanced in the presence of the NPs.…”

Section: Biomedical Applications: Fiber-based Systemsmentioning

confidence: 99%

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Bioactivity of Chitosan-Based Particles Loaded with Plant-Derived Extracts for Biomedical Applications: Emphasis on Antimicrobial Fiber-Based Systems

et al. 2021

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Marine-derived chitosan (CS) is a cationic polysaccharide widely studied for its bioactivity, which is mostly attached to its primary amine groups. CS is able to neutralize reactive oxygen species (ROS) from the microenvironments in which it is integrated, consequently reducing cell-induced oxidative stress. It also acts as a bacterial peripheral layer hindering nutrient intake and interacting with negatively charged outer cellular components, which lead to an increase in the cell permeability or to its lysis. Its biocompatibility, biodegradability, ease of processability (particularly in mild conditions), and chemical versatility has fueled CS study as a valuable matrix component of bioactive small-scaled organic drug-delivery systems, with current research also showcasing CS’s potential within tridimensional sponges, hydrogels and sutures, blended films, nanofiber sheets and fabric coatings. On the other hand, renewable plant-derived extracts are here emphasized, given their potential as eco-friendly radical scavengers, microbicidal agents, or alternatives to antibiotics, considering that most of the latter have induced bacterial resistance because of excessive and/or inappropriate use. Loading them into small-scaled particles potentiates a strong and sustained bioactivity, and a controlled release, using lower doses of bioactive compounds. A pH-triggered release, dependent on CS’s protonation/deprotonation of its amine groups, has been the most explored stimulus for that control. However, the use of CS derivatives, crosslinking agents, and/or additional stabilization processes is enabling slower release rates, following extract diffusion from the particle matrix, which can find major applicability in fiber-based systems within ROS-enriched microenvironments and/or spiked with microbes. Research on this is still in its infancy. Yet, the few published studies have already revealed that the composition, along with an adequate drug release rate, has an important role in controlling an existing infection, forming new tissue, and successfully closing a wound. A bioactive finishing of textiles has also been promoting high particle infiltration, superior washing durability, and biological response.

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Biopolymers for Wound Healing Applications

Chopra

2024

Biopolymers for Biomedical Applications

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Wound healing performance of PCL/chitosan based electrospun nanofiber electrosprayed with curcumin loaded chitosan nanoparticles

Cited by 228 publications

References 55 publications

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Bioactivity of Chitosan-Based Particles Loaded with Plant-Derived Extracts for Biomedical Applications: Emphasis on Antimicrobial Fiber-Based Systems

Biopolymers for Wound Healing Applications

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