Wound healing potential of forest honey for increasing TGF-β1 protein expression in palatoplasty: In-vivo and In-silico studies

Wardana, Tirta; Aida, AlifahNur; Zhafirah, Reine; Hirawan, Helmi; Widodo, Abdul Haris Budi; Prihastuti, ChristinaCahyani

doi:10.4103/sdj.sdj_95_21

Cited by 4 publications

(1 citation statement)

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“…Flavonoids also have antibacterial, antioxidant, and anti-inflammatory properties. 19 The results of this study indicate that administering Trigona honey twice daily led to a faster healing process than once daily; this agreed with research conducted by Takzaree et al, who reported that applying honey to wounds twice daily increases healing, shortens the inflammatory process, and increases the granulation rate. 20 Turmeric extracts in 50% and 75% gels can be used as an alternative treatment because they accelerate wound healing, although not as quickly as Trigona honey (Tables 2-5).…”

Section: Discussionsupporting

confidence: 91%

Turmeric extract gel and honey in post-cesarean section wound healing: A preliminary study

Nilawati Usman,

Sartini,

Yulianti

et al. 2023

F1000Res

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Background: Delivery by cesarean section (SC) increases the risk of a surgical site infection (SSI). Therapy from health services and complementary therapy reduce the risk of infection and accelerate the wound-healing process. This study compared wound healing after SC with a turmeric extract gel and original Trigona honey. Methods: Female white rats (Rattus novergicus) with pre- and post-testing and a control group were included in this experiment, which was conducted in June-July 2022. The test animals were 56 female white rats, 2-4 months old, weighing 150–350 g. The treatment group was divided into three subgroups with application of 50% and 75% turmeric extract gel and Trigona honey. The turmeric was given twice daily, and the honey was divided into two applications of twice a day and once a day. Wounds were assessed using the Reeda Scale. Results: The fastest wound healing occurred in the group given Trigona honey twice daily. Redness, ecchymosis, and edema disappeared in this group on day 9 (score 0), and granulation tissue formed on day 9. The group that was administered 50% and 75% turmeric gel extract and Trigona honey once a day healed by days 12 and 15, respectively; all three of these interventions were better than the control group. Conclusions: Administering Trigona honey twice daily was more effective for accelerating wound healing than the 50% or 75% turmeric extract gel. Original Trigona honey has the potential to be a post-SC wound healing agent.

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Section: Discussionsupporting

confidence: 91%