Wound healing potential of the ethanolic extracts of Bidens pilosa and Ocimum suave

Abstract

The ethanolic extracts of Bidens pilosa and Ocimum suave were evaluated for their wound healing potential on excision wound models in Wistar albino rats. A total of nine (n=9) rats per group were used to assess the wound healing potential of the extracts. There were four groups of animals treated topically twice a day with either of the following: O. suave, B. pilosa, neomycin sulfate or distilled water. The rate of wound contraction, epithelialization, and complete healing were assessed over the experimental period. Wounds treated with extracts of O. suave, B. pilosa and neomycin sulfate had faster rates of wound contraction (p<0.05) on days 3, 6 and 9 than negative control. Histological examination of wound on day 7 also revealed better collagenation, angiogenesis and organization of the wound tissue. Epithelialisation and total healing time for B. pilosa and O. suave were comparable to neomycin sulfate (p>0.05). In conclusion, extracts of O. suave and B. pilosa show potential for use as alternative to neomycin for treatment of wounds.

Bidens pilosaL. (Asteraceae): Botanical Properties, Traditional Uses, Phytochemistry, and Pharmacology

“…Hassan and colleagues investigated the wound healing potential of B. pilosa in Wistar rats [127]. Mirroring the positive control neomycin sulfate, the ethanol extract of B. pilosa had faster wound closure than control rats 3, 6, and 9 days after topical application.…”

In vivo anti-inflammatory activities of Ocimum suave in mice

“…Though there are reports on the analgesic (Makonnen et al, 2003a), antipyretic, (Makonnen et al, 2003b), gastric cytoprotective antiulcer effects on acute gastric ulcer (Tan et al, 2002) and healing effects on chronic acetic acid-induced gastric ulcers (Tan et al, 2005), mosquito repellent (Seyoum et al, 2002), antimicrobial (Runyoro et al, 2010) and wound healing activity (Hassan et al, 2011), its anti-inflammatory activity has not yet been confirmed scientifically. The present study was, therefore, carried out to evaluate the anti-inflammatory activities of the crude leaf extracts and some fractions of Ocimum suave.…”

<i>In vivo</i> analgesic and antipyretic activities of N-Butanol and water fractions of <i>Ocimum sauve</i>

“…The leaves extract of O. suave has been reported to exhibit the mosquito repellent ( 11 ), acaricidal ( 12 ), anti-inflammatory ( 13 ), antidiabetic ( 14 ), wound healing and anti-ulcer activities ( 8 , 15 , 16 ). It has also been shown to possess analgesic and antipyretic activities.…”