Wound Healing Process of Injured Pulp Tissues with Emdogain Gel

Recent Advances in Pulp Capping Materials: An Overview

“…Recently,it was reported that EMD suppresses the inflammatory cytokine production by immunocytes and contains TGF-b like molecules. It might create a favourable environment for promoting wound healing in the injured pulp tissues [34]. Nakamura Y et al, concluded that amount of hard tissue formed in EMD treated teeth was more than twice that of the calcium hydroxide treated control teeth [35].…”

Can interaction of materials with the dentin-pulp complex contribute to dentin regeneration?

“…In comparative pulp-capping studies, calcium hydroxide, BMP-7, and bone sialoprotein have been shown to produce reparative dentin in rat molars with pulpal exposures, with the bioactive molecules showing a signifi cantly stronger effect than the dental materials. 61 Others have shown similar comparisons to calcium hydroxide with other preparations containing bioactive molecules, such as enamel matrix derivatives, 62,63 with verifi cation of a more rapid expression of proteins related to dentin formation. 64 Thus, it is tempting to propose that the mechanism of dentin regeneration with calcium hydroxide may be similar to that produced by direct application of bioactive molecules to the pulp tissue, but that the extent and rate are reduced for calcium hydroxide because of its weaker ability to extract similar molecules directly from the host dentin, or to the fi nite amount of molecules available.…”

“…Evidence for quicker healing was an increased number of BMP-expressing macrophages present with Emdogain, resulting in larger amounts of reparative dentin formation earlier in the process. 62 The extent to which fi ndings from the rat molar model of reparative dentinogenesis can be extrapolated to the human or other species is unclear. Although reparative dentinogenesis can be readily triggered in this model, the balance between regeneration and other wound healing responses requires further elucidation.…”

Diş hekimliğinde Emdogain

“…29 EMD ile güçlendirilmiş alkalen fosfat aktivitesi ve osteoblastlardaki BMP ekspresyonu ve dentinden isim almış kemik matriks proteinlerinden olan Dentin matriks protein 1 (DMP-1), yaralanmış pulpanın durumunu ve tamir dentininin yapımını güçlendirmek için bölgeye ilk olarak gitmektedi. 30 Kaida ve arkadaşlarının 31 EMD'nin pulpa dokusu üzerindeki iyileşme süreci hakkında ratlar üzerinde yap-N B Özerol ve ark.…”

“…EMD ile tedavide, IL-1β hücre sayısının diğer gruplara oranla belirgin bir şekilde düşük olduğu görülmüştür. 31 Nakamura ve arkadaşlarının 36 EMD ve kalsiyum hidroksitin pulpa kuafajındaki etkilerini karşılaştırdıkları ça-lışmada tedaviden 2 hafta sonra EMD ile tedavi edilen dişlerde nekrotik tabakanın kronik inflamatuar hücreler ile infiltre olduğu gözlemlenmiştir. Kalsiyum hidroksitle tedavi edilen grupta inflamatuar hücreler görülmemiştir; fakat ne odontoblastlar ne yeni dentin oluşumu direkt olarak pulpal yara üzerinde değildir.…”