Wound-healing properties of copper nanoparticles as a function of physicochemical parameters

Rakhmetova, A. A.; Alekseeva, T. P.; Bogoslovskaya, O. A.; Лейпунский, И. О.; Olkhovskaya, I. P.; Жигач, А. Н.; Глущенко, Н. Н.

doi:10.1134/s199507801003016x

Cited by 68 publications

(37 citation statements)

References 4 publications

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“…Thus, chelation therapies are under intense clinical investigation (ClinicalTrial.gov, example trial identifiers: NCT00195091, NCT00176800 and NCT01178112). Furthermore, evidence from several in vivo studies suggests that the clinical modulation of local tissue copper may be a promising tool to promote the regeneration of blood flow within injured areas [9,10,11,12,13]. In line with that, copper levels at wound sites are reportedly higher than in peri-wound skin [10] and they amount to approximately 30 μ M [14].…”

Section: Copper As a Common Denominator Of Physiological Pathologicamentioning

confidence: 73%

Behind the Link between Copper and Angiogenesis: Established Mechanisms and an Overview on the Role of Vascular Copper Transport Systems

Urso

Maffia²

2015

J Vasc Res

129

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Angiogenesis critically sustains the progression of both physiological and pathological processes. Copper behaves as an obligatory co-factor throughout the angiogenic signalling cascades, so much so that a deficiency causes neovascularization to abate. Moreover, the progress of several angiogenic pathologies (e.g. diabetes, cardiac hypertrophy and ischaemia) can be tracked by measuring serum copper levels, which are being increasingly investigated as a useful prognostic marker. Accordingly, the therapeutic modulation of body copper has been proven effective in rescuing the pathological angiogenic dysfunctions underlying several disease states. Vascular copper transport systems profoundly influence the activation and execution of angiogenesis, acting as multi-functional regulators of apparently discrete pro-angiogenic pathways. This review concerns the complex relationship among copper-dependent angiogenic factors, copper transporters and common pathological conditions, with an unusual accent on the multi-faceted involvement of the proteins handling vascular copper. Functions regulated by the major copper transport proteins (CTR1 importer, ATP7A efflux pump and metallo-chaperones) include the modulation of endothelial migration and vascular superoxide, known to activate angiogenesis within a narrow concentration range. The potential contribution of prion protein, a controversial regulator of copper homeostasis, is discussed, even though its angiogenic involvement seems to be mainly associated with the modulation of endothelial motility and permeability.

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Section: Copper As a Common Denominator Of Physiological Pathologicamentioning

confidence: 73%

Behind the Link between Copper and Angiogenesis: Established Mechanisms and an Overview on the Role of Vascular Copper Transport Systems

Urso

Maffia²

2015

J Vasc Res

129

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“…The research of physical and chemical characteristics revealed the following: copper nanoparticles have spherical form; average size is 103.0 nm ± 2.0 nm; nanoparticle nucleus contains 96.0% ± 4.5% crystal copper, -4.0% ± 0.4 % copper oxide; thickness of oxide film on the surface is -6 nm [18]. Recent researches on biological action of unmodified copper nanoparticles after one-fold subcutaneous introduction allow to establish nanoparticle regular effect on the organism depending on the metal dosage.…”

Section: Structural Changes In Tissues Of Animals At Copper Nanopartimentioning

confidence: 99%

Copper Nanoparticles as Modulators of Apoptosis and Structural Changes in Tissues

Sizova¹,

Miroshnikov²,

Polyakova³

et al. 2012

JBNB

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“…Similar results reported Grass et al 23 , demonstrating that cells are damaged in their cytoplasmic membrane and weakened in their cell wall a few minutes after incubation in the presence of copper. On the other hand, Rakhmetova et al 24 showed through electron microscopy that the metal microparticles and groups of them are located near the bacterial cell wall where they can liberate more toxic ions, which flow into the cytoplasm and can lead to cell death. …”

Section: Effect Of Cu 2 O and Cuo On E Coli Atcc 25922mentioning

confidence: 99%

PVC/Copper Oxide Composites and Their Effect on Bacterial Adherence

Rodríguez-Llamazares¹,

Mondaca²,

Badilla³

et al. 2012

J. Chil. Chem. Soc.

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In this work, PVC/CuO and PVC/Cu 2 O composites were prepared by melt-blending method. The results of scanning electron microscopy (SEM) -X ray energy dispersive spectroscopy (EDS) Cu-mapping showed that the composites are a hybrid of the polymer and the copper oxide particles, and these particles were distributed uniformly in the polymer matrix. The adherence of Escherichia coli ATCC 25922 on the surface of composite materials was assessed through the inventory of adhered viable cells and SEM analysis. In PVC/copper oxide composite, the number of adhered bacterial cells was reduced by almost 2 units log 10 with regard to those adhere to the pure PVC polymer. SEM images of composite materials showed a significant decrease in bacterial adherence when compared to the pure polymer. It was also found through transmission electron microscopy (TEM) images to that E. coli incubated in the presence of cuprous oxide (Cu 2 O) and cupric oxide (CuO) microparticles go through structural and morphological changes at the membrane level. Bacterial cells incubated in the presence of Cu 2 O were bacillary with blunt ends, and their size was reduced by 30% when compared to those incubated in the absence of copper oxides. The results obtained indicate that the PVC/copper oxide composites inhibit the adhesion of E. coli to their surface.

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Wound-healing properties of copper nanoparticles as a function of physicochemical parameters

Cited by 68 publications

References 4 publications

Behind the Link between Copper and Angiogenesis: Established Mechanisms and an Overview on the Role of Vascular Copper Transport Systems

Behind the Link between Copper and Angiogenesis: Established Mechanisms and an Overview on the Role of Vascular Copper Transport Systems

Copper Nanoparticles as Modulators of Apoptosis and Structural Changes in Tissues

PVC/Copper Oxide Composites and Their Effect on Bacterial Adherence

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