Wound healing properties of <i>Hylocereus undatus</i> on diabetic rats

Effective wound healing leads to restoration of tissue integrity and occurs through a highly organized multistage process involving various cell types. Currently, methods for wound healing assessment lack a structured system for analysis of quantitative parameters. We have established a unique quantitative assessment strategy of wound healing stages based on histological criteria. Distinctive immunohistochemical parameters including re-epithelialization, epidermal differentiation, cell migration, proliferation, inflammatory response as well as dermal closure, matrix distribution, and skin remodelling were identified and followed during the timeline of wound healing progression. Assessment was based on various defined characteristics and each stage-specific parameter was independently quantified for complete wound closure. This analysis allowed a follow-up of wound healing dynamics and identified the contribution of critical and specific parameters to wound healing physiology and pathology. In this review we demonstrate our assessment strategy of crucial wound healing events and introduce a unique quantification system for each of the processes involved in wound repair. We believe that our unique method can be utilized as a diagnostic platform for standardizing assessment of wound healing progression as well as a screening tool for potential therapies.

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“…various complications of this disease (Seifter et al, 1981;Franzen and Roberg, 1995;Schaffer et al, 1997;Perez et al, 2005).…”

Section: Use Of the Healor Assessment Strategy For Analyzing Diabeticmentioning

confidence: 99%

Novel Insights into Wound Healing Sequence of Events

et al. 2007

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“…The continuous threads on both wound edges are tightened for good closure of the wound. The wounds were left undressed and mopped with a cotton swab [45, 46]. The respective therapeutic treatment is administered either orally or topically to the animals of respective groups until 7th–9th day starting from the day of operation.…”

Section: Wound Creationmentioning

confidence: 99%

Practices in Wound Healing Studies of Plants

Thakur¹,

Jain²,

Pathak³

et al. 2011

Evidence-Based Complementary and Alternative Medicine

248

196

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Wounds are the result of injuries to the skin that disrupt the other soft tissue. Healing of a wound is a complex and protracted process of tissue repair and remodeling in response to injury. Various plant products have been used in treatment of wounds over the years. Wound healing herbal extracts promote blood clotting, fight infection, and accelerate the healing of wounds. Phytoconstituents derived from plants need to be identified and screened for antimicrobial activity for management of wounds. The in vitro assays are useful, quick, and relatively inexpensive. Small animals provide a multitude of model choices for various human wound conditions. The study must be conducted after obtaining approval of the Ethics Committee and according to the guidelines for care and use of animals. The prepared formulations of herbal extract can be evaluated by various physicopharmaceutical parameters. The wound healing efficacies of various herbal extracts have been evaluated in excision, incision, dead space, and burn wound models. In vitro and in vivo assays are stepping stones to well-controlled clinical trials of herbal extracts.

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“…[50], Passiflora edulis Sims. f [51], Hylocereus undatus (Haworth) Britton & Rose [52], Luffa cylindrical (L.) Roem [53], Momordica charantia L. [53] and Panax ginseng L. [13] possess cAMP phosphodiesterase inhibitory activity, as a result of which the action of insulin is retained.…”

Section: Insulin Mimetic Natural Drugsmentioning

confidence: 99%

A Target Based Therapeutic Approach Towards Diabetes Mellitus Using Medicinal Plants

Prabhakar

Doble

2008

CDR

147

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Diabetes mellitus (DM) is not one disease but is a heterogonous group of syndromes. Contrary to the popular belief DM is a metabolic disorder characterized by increased blood glucose level (hyperglycemia) and this is because of insufficient or inefficient insulin secretary response. Glucose is the main energy source for the body, and in the case of DM, management of glucose becomes irregular. There are around 410 experimentally proven medicinal plants having antidiabetic properties but the complete mechanism of action is available only for about 109. There are several medicinal plants whose extract modulate glycolysis, Krebs cycle, gluconeogenesis, HMP shunt pathway, glycogen synthesis and their degradation, cholesterol synthesis, metabolism and absorption of carbohydrates, and synthesis and release of insulin. This paper provides a comprehensive review of the mode of action of medicinal plants that exhibit anti-diabetic properties.

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Wound healing properties of Hylocereus undatus on diabetic rats

Cited by 50 publications

References 9 publications

Novel Insights into Wound Healing Sequence of Events

Novel Insights into Wound Healing Sequence of Events

Practices in Wound Healing Studies of Plants

A Target Based Therapeutic Approach Towards Diabetes Mellitus Using Medicinal Plants

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