Wound-Healing Property of<i>Momordica charantia</i>L. Fruit Powder

Prasad, V. Satya; Jain, Vikas; Girish, D.P.; Dorle, A. K.

doi:10.1080/j157v06n03_05

Cited by 21 publications

(2 citation statements)

References 10 publications

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“…The wound-healing efficacy of M. charantia fruit powder was studied in rats utilizing an excision, incision, and dead space wound model. The powder ointment showed a statistically significant response in wound-contracting ability, wound closure time, length of epithelization, wound tensile strength, and wound tissue regeneration compared to the control group[ 119 ]. A study evaluated the alterations in transforming growth factor (TGF) expression in diabetic lesions treated with topical M. charantia fruit extract.…”

Section: Discussionmentioning

confidence: 99%

Acknowledging the use of botanicals to treat diabetic foot ulcer during the 21^st century: A systematic review

Narzary¹,

Swarnakar²,

Kalita³

et al. 2023

World J Clin Cases

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BACKGROUND Diabetic foot ulcer (DFU) is a serious health issue of diabetes mellitus that affects innumerable people worldwide. Management and treatment of this complication are challenging, especially for those whose immune system is weak. AIM To discuss the plants and their parts used to heal DFU, along with the mode of their administration in diabetic patients. METHODS The original articles on “the plants for the treatment of DFU” studied in clinical cases only were obtained from various bibliographic databases using different keywords. RESULTS The search resulted in 22 clinical cases records with 20 medicinal plants belonging to 17 families on 1553 subjects. The fruits and leaves were the most preferentially used parts for DFU treatment, regardless of whether they were being administered orally or applied topically. Of the 20 medicinal plants, 19 reported their effectiveness in increasing angiogenesis, epithelialization, and granulation, thus hastening the wound-healing process. The efficacy of these botanicals might be attributed to their major bioactive compounds, such as actinidin and ascorbic acid (in Actinidia deliciosa ), 7-O-(β-D-glucopyranosyl)-galactin (in Ageratina pichinchensis ), omega-3-fatty acid (in Linum usitatissimum ), isoquercetin (in Melilotus officinalis ), anthocyanins (in Myrtus communis ), and plantamajoside (in Plantago major ). CONCLUSION The validation of mechanisms of action underlying these phytocompounds contributing to the management of DFU can aid in our better understanding of creating efficient treatment options for DFU and its associated problems.

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Section: Discussionmentioning

confidence: 99%

Acknowledging the use of botanicals to treat diabetic foot ulcer during the 21^st century: A systematic review

Narzary¹,

Swarnakar²,

Kalita³

et al. 2023

World J Clin Cases

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“…It is widely distributed in tropical regions of South East and Far East Asia to Australia and South Africa. M. charantia possesses antidiabetic, antihyperlipidemic and anticarcinogenic anti-HIV, anthelmintic, antitumor, and wound healing properties [15, 16, 17, 18, 19]. Fresh juice of bitter melon inhibited lipogenesis [20].…”

Section: Introductionmentioning

confidence: 99%

Antihyperlipidemic screening and plasma uric acid reducing potential of Momordica charantia seeds on Swiss albino mice model

Hussain

Jahan

Rashid

et al. 2019

Heliyon

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The global prevalence of hyperlipidaemia is increasing rapidly and high dietary fat intake is a major risk factor for developing hyperlipidaemia. An in-vivo biological investigation was carried out on ethanolic extract of Momordica charantia, a plant belonging to the family Cucurbitaceae for the evaluation of antihyperlipidemic activity and serum uric acid reducing potential. In our study, 25 healthy male mice were selected randomly and grouped into 5 groups (5 animals in each group). Lipid and uric acid profile were estimated after 21 days of treatment by using the enzymatic colourimetric GPO-PAP method. Results showed that ethanolic extract of M. charantia at a dose of 200 mg/kg body weight showed significant (p < 0.05) cholesterol and triglyceride level reduction profile when co-administrated with 20% fat and normal feed respectively. Atorvastatin was used as standard. Data from pathological examination showed that the average weight of the heart of the mice was normal for every group when compared with control. Gr-2 (normal and extract feed) showed significant (p ˂ 0.05) increased of liver and kidney weight rather than experimental groups; however, these values were lower than the values for the control group. Uric acid level determination revealed that the ethanolic extract of M. charantia reduced serum uric acid level both in experimental groups (Gr-2 and Gr-3). Thus a considerable correlation was found between serum uric acid reducing potentials of the present plant extract with a lipid-lowering profile. This plant can be further investigated thoroughly as a potential source of chemically interesting and biologically important drug candidates.

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Bitter Gourd: Botany, Horticulture, Breeding

Behera

Bharathi

et al. 2010

Horticultural Reviews, Volume 37

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The vegetable Moinordica charontja L., CucurbitaCeae, is known variously as bitter gourd, balsam pear, bitter melon, bitter cucumber, and African cucumber (Heiser 1979). Although it has many culinary uses, especially in south, southeast and east Asia, it is also grown as an ornamental and is used extensively in folk medicine (Heiser 1979). The fruits are cooked with other vegetables, stuffed, stir-fried, or added in small quantities to beans and soups to provide a slightly bitter flavor. However, for most food preparation, fruits are blanched, parboiled, or soaked in salt water before cooking to reduce the bitter taste. In addition to frying or cooking (e.g., for curries), the fruits can be dehydrated, c

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Wound-Healing Property ofMomordica charantiaL. Fruit Powder

Cited by 21 publications

References 10 publications

Acknowledging the use of botanicals to treat diabetic foot ulcer during the 21^st century: A systematic review

Acknowledging the use of botanicals to treat diabetic foot ulcer during the 21^st century: A systematic review

Antihyperlipidemic screening and plasma uric acid reducing potential of Momordica charantia seeds on Swiss albino mice model

Bitter Gourd: Botany, Horticulture, Breeding

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Wound-Healing Property ofMomordica charantiaL. Fruit Powder

Cited by 21 publications

References 10 publications

Acknowledging the use of botanicals to treat diabetic foot ulcer during the 21st century: A systematic review

Acknowledging the use of botanicals to treat diabetic foot ulcer during the 21st century: A systematic review

Antihyperlipidemic screening and plasma uric acid reducing potential of Momordica charantia seeds on Swiss albino mice model

Bitter Gourd: Botany, Horticulture, Breeding

Contact Info

Product

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Acknowledging the use of botanicals to treat diabetic foot ulcer during the 21^st century: A systematic review

Acknowledging the use of botanicals to treat diabetic foot ulcer during the 21^st century: A systematic review