Wound-Healing Property of Momordica charantia L. Fruit Powder

Prasad, V. Satya; Jain, Vikas; Girish, D.P.; Dorle, A. K.

doi:10.1300/j157v06n03_05

Cited by 15 publications

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“…Bitter melon has been shown to possess a wound-healing property [31,46]. Wound healing is a complex process of inflammation, granulation tissue formation, angiogenesis, re-epithelialization and remodeling [47].…”

Section: Discussionmentioning

confidence: 99%

Induction of hepatocyte growth factor production in human dermal fibroblasts and their proliferation by the extract of bitter melon pulp

et al. 2009

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Hepatocyte growth factor (HGF) is useful as a potential therapeutic agent for hepatic and renal fibrosis and cardiovascular diseases through inducing proliferation of epithelial and endothelial cells. HGF inducers may also be useful as therapeutic agents for these diseases. However, there have been no reports on induction of HGF production by plant extracts or juices. An extract of bitter melon (Momordica charantia L.) pulp markedly induced HGF production. There was a time lag of 72 h before induction of HGF production after the extract addition. Its stimulatory effect was accompanied by upregulation of HGF gene expression. Increases in mitogen-activated protein kinases (MAPKs) were observed from 72 h after the extract addition. Inhibitors of MAPKs suppressed the extract-induced HGF production. The extract also stimulated cell proliferation.Both activities for induction of HGF production and cell proliferation were eluted together in a single peak with 14 000 Da on gel filtration. The results indicate that bitter melon pulp extract induced HGF production and cell proliferation of human dermal fibroblasts and suggest that activation of MAPKs is involved in the HGF induction. Our findings suggest potential usefulness of the extract for tissue regeneration and provide an insight into the molecular mechanism underlying the wound-healing property of bitter melon.

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Section: Discussionmentioning

confidence: 99%

Induction of hepatocyte growth factor production in human dermal fibroblasts and their proliferation by the extract of bitter melon pulp

et al. 2009

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“…It is a very common herb having various medicinal properties, viz. antifungal (Santos et al, 2012), wound healing (Prasad et al, 2006), antiviral (Balasubramanian et al, 2007) and antidiabetic (Denyer et al, 2004). Bitter melon is an important nutrient rich plant composed of variety of beneficial compounds.…”

Section: In Asian Countriesmentioning

confidence: 99%

Effect of Sodium Arsenate on Momordica charantia L. Seeds In Vitro

Ray¹,

Raychaudhuri²

2017

Int. J. Curr. Res. Biosci. Plant Biol.

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A b s t r a c t A r t i c l e I n f oMomordica charantia (bitter melon) is a vegetable crop plant of the family Cucurbitaceae.Momordica is a medicinally important plant species and widely used as foodstuff. Arsenic (As) is one of the toxic environmental pollutants, which has recently attracted mass attention because of its chronic and epidemic effects on human health. The absorption of As by land plants is influenced by the concentration of As in the soil. With this perspective the present investigation was undertaken to carry out a comparative analysis on fruit yield and in vitro efficiency of Momordica to establish callus culture from seeds collected from geographically arsenic contaminated and arsenic free two places in West Bengal, India. Calli established in vitro were subjected to Scanning Electron Microscopy (SEM) to determine effect of arsenic on morphological alteration of calli. Seedlings grown in arsenic containing media were used for Atomic Absorption Spectroscopic (AAS) analysis to get a clear picture of the content of eight metals under excess arsenic treatment.

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“…Kudret narı bitkisinden elde edilen ekstraktların, topikal olarak uygulanarak, yara iyileşmesindeki etkinliğinin incelendiği çalışmalarda, bitkinin sahip olduğu geniş spekturumlu antibakteriyel aktivite, antioksidan, antienflamatuar, analjezik ve antiülser özelliklerinden dolayı yara iyileşmesinde oldukça etkili bir rolü olduğu saptanmıştır [41][42][43][44][45].…”

Section: Kudret Narının Yara İyileşmesindeki Rolüunclassified

“…İlişkin Yapılan Çalışmalar Kudret narı bitkisinin yara iyileşmesindeki etkinliğinin incelendiği deney hayvanlarıyla yapılan çalışmalarda, yara kontraksiyon yeteneği, yara kapanma zamanı, epitelizasyon süreci, yaranın gerilme kuvveti ve yara iyileşme hızı bakımından kudret narının etkili olduğunu gösteren birçok çalışma mevcuttur [41][42][43][44][45][46]60].…”

Section: Kudret Narının Yara İyileştirici öZelliğineunclassified

“…Çalışmanın sonucunda kudret narı meyvesinden hazırlanan merhemin kullanıldığı deney grubunda yara iyileşmesine yönelik anlamlı sonuçlar elde edilmiş, 14.günde kudret narı meyvesinden hazırlanan pomadın kullanıldığı tedavi grubunda %100'e yakın bir kapanma gözlenirken, aynı günde kapanma hızının %0.2'lik povidon iodinin kullanıldığı grupta %52.3, kontrol grubunda ise %68.4 olduğu saptanmıştır. Yaraların histolojik değerlendirilmesinde ise, epitelizasyon ve kollajen puan ortalamasının kudret narı grubunda daha yüksek olduğu ve kudret narının yeni damar oluşumunda önemli rol oynayan Şekil 1: Kudret Narı Bitkisi büyüme faktörlerinin üretilmesini ve dermal fibroblast hücrelerinin çoğalmasını sağladığı belirlenmiştir [41].…”

Section: Kudret Narının Yara İyileştirici öZelliğineunclassified

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The effect of Momordica on wound healing

Kısacık¹,

Güneş²

2017

Spatula DD

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ÖZETTıbbi bitkiler kapsamında bilinen bitkilerden biri de Kudret narıdır. Kudret narının bilinen önemli etkilerinden biri de yarayı iyileştirici özelliğidir. Kudret narı bitkisinin olgunlaşmış meyveleri yaraların tedavisinde kullanılmaktadır. Bitkinin yara iyileşme sürecinde; büyüme faktörlerinin üretilmesini hızlandırdığı, fibroblast hücrelerinin çoğalmasını sağladığı, kapiller dolaşımı hızlandırarak yara iyileşmesinde önemli bir faktör olan oksijenlemeyi arttırdığı, bileşimindeki flavanoid, glikozid gibi birçok fitokimyasalın, antioksidan ve antimikrobiyal aktivitelerinden dolayı yara iyileşme sürecini hızlandırdığı, yara kontraksiyon yeteneği, yara kapanma zamanı, epitelizasyon süreci, yaranın gerilme kuvveti ve yara iyileşme hızı bakımından olumlu sonuçlara neden olduğu belirtilmiştir. ANAHTAR KELIMELER: Yara; Yara iyileşmesi; Kudret narı The effect of Momordica on wound healingABSTRACT Momordica is one of the medicinal plants. One of the known effects of momordica is wound healing. The ripe fruits of momordica are used for treatment of wounds. The plant has been reported to precipitate growth factor production, stimulate fibroblast proliferation, increase oxygenation, to be an important factor in wound healing through accelerating capillary circulation. Many phyto-chemicals such as flavonoid and glycoside found in its composition have been reported to accelerate wound healing through anti-oxidant and anti-microbial activities and lead to positive outcomes with regard to wound contraction ability, wound closure time, epithelization process, tensile strength of the wound and the wound healing rate.

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Wound-Healing Property of Momordica charantia L. Fruit Powder

Cited by 15 publications

References 0 publications

Induction of hepatocyte growth factor production in human dermal fibroblasts and their proliferation by the extract of bitter melon pulp

Induction of hepatocyte growth factor production in human dermal fibroblasts and their proliferation by the extract of bitter melon pulp

Effect of Sodium Arsenate on Momordica charantia L. Seeds In Vitro

The effect of Momordica on wound healing

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