Wound healing prospective of pongamia glabra, piper nigrum and momordica charantia on albino rats using anemic burn wound model

Abstract

Objective: The objective of present work was to evaluate wound healing potential of pongamia glabra, piper nigrum and momordica charantia using as herbal ointment formulation on albino rats using burn wound model. All the plant has the rich source of alkaloid, glycoside, tannins, carbohydrates, saponins, flavonoids, proteins and amino acids content and were used as anti-diabetic, anti-inflammatory, antitumor, anti-malarial and having wound healing potential. Materials and Methods: Extract of all three plants has been separated by the Soxhlet extraction. Herbal ointment formulation has been prepared by mixing the extract of momordica charantia, pongamia glabra and piper nigrum with the wool fat and paraffin. Burn wound model has been utilized for the evaluation of wound healing potential. Histopathological evaluation has been also carried-out for the physical verification wound healing potential. Results and Conclusion: The studies on burn wound healing model reveals that all twelve groups showed decreased wound area on the time and there was no mortality observed in the course of study. Discussion: These studies have indicated that herbal ointment formulation of pongamia glabra, piper nigrum and momordica charantia has been utilized for wound healing and it is safer for topical application. No toxicity and mortality have been observed during the experimental tenure. 
 Keywords: Wound healing, momordica charantia, pongamia glabra, piper nigrum, burn wound model

Development, characterization and evaluation of herbal ointment containing momordica charantia, pongamia glabra and piper nigrum

“…In addition our two published research paper 13,14 indicate the efficacy and effectiveness of poly-herbal ointment F2 (formulation code) in enhancing wound healing activities. In that cases when momordica and pongamia when administered orally and topically with piper they had shown significant synergistic activity.…”

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“…[14] The AH [ Figure 1] contains various chemical constituents, i.e., artocarpin, artocarpetin, norartocarpetin, atropine, cycloartinone morin, dihydromorin, cynomycin, and artocarpanone. [15] The AH may contains albumin 1.7%, cellulose 59.0%, lipid 1.7%, moisture 6.7%, and glycosides 38.0%, [16,17] root contains β-sitosterol, ursolic acid, betulinic acid, and cycloartenone, [18] and latex is used as an anti-inflammatory agent. [19] MK is identified as curry leaf [ Figure 2].…”

“…All process were repeated in duplicate and regression equation used to calculate total phenole content of the extracts. [17]…”

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“…[3,4] Many artificial antioxidants have been utilized for wound healing but produce toxic substances, which shall harm human health. Higher ingestion of natural resources such as vegetables and fruits has been proven to reduce the risk [5,6] and contains phytochemicals such as carotenoids, alkaloids, vitamins, minerals, and polyphenols [7] those proves beneficiary effects of antioxidant and utilized for wound healing potential. Hard-to-heal wounds become chronic when the wound is associated with the condition such as vascular disease, diabetes, neuropathy, liver diseases, and hyperglycemia.…”