Wound healing with alginate/chitosan hydrogel containing hesperidin in rat model

Bagher, Zohreh; Ehterami, Arian; Safdel, Mohammad Hossein; Khastar, Hossein; Semiari, Hossein; Asefnejad, Azadeh; Davachi, Seyed Mohammad; Mirzaii, Mehdi; Salehi, Majid

doi:10.1016/j.jddst.2019.101379

Cited by 144 publications

(84 citation statements)

References 49 publications

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“…These hydrogels displayed suitable porosity of 91.2% with interrelated pores, appropriate swelling capacity, and biodegradability confirmed by weight loss of over 80% after 2 weeks. The in vivo wound healing studies demonstrated that the formulated hydrogels had a better wound closure when compared to the gauze-treated wound, especially the hydrogels loaded with 10% of hesperidin [ 66 ]. Ehterami et al reported similar findings as Baghe et al for alginate/chitosan-based hydrogel loaded with Alpha-tocopherol for wound management in vivo [ 67 ].…”

Section: Preparation Techniques and Properties Of Hydrogelsmentioning

confidence: 99%

Chitosan and Cellulose-Based Hydrogels for Wound Management

Alven

Aderibigbe

2020

IJMS

223

111

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Wound management remains a challenge worldwide, although there are several developed wound dressing materials for the management of acute and chronic wounds. The wound dressings that are currently used include hydrogels, films, wafers, nanofibers, foams, topical formulations, transdermal patches, sponges, and bandages. Hydrogels exhibit unique features which make them suitable wound dressings such as providing a moist environment for wound healing, exhibiting high moisture content, or creating a barrier against bacterial infections, and are suitable for the management of exuding and granulating wounds. Biopolymers have been utilized for their development due to their non-toxic, biodegradable, and biocompatible properties. Hydrogels have been prepared from biopolymers such as cellulose and chitosan by crosslinking with selected synthetic polymers resulting in improved mechanical, biological, and physicochemical properties. They were useful by accelerating wound re-epithelialization and also mimic skin structure, inducing skin regeneration. Loading antibacterial agents into them prevented bacterial invasion of wounds. This review article is focused on hydrogels formulated from two biopolymers—chitosan and cellulose—for improved wound management.

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Section: Preparation Techniques and Properties Of Hydrogelsmentioning

confidence: 99%

Chitosan and Cellulose-Based Hydrogels for Wound Management

Alven

Aderibigbe

2020

IJMS

223

111

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“…In our research, we used alginates, which constitute linear polymers composed of (1→4)-α-L-guluronic acid blocks (GG), (1→4)-β-D-mannuronic acid blocks (MM) and, additionally, heteropolymeric sequences of M and G (MG blocks) [11,12]. Moreover, in the case of the preparation of hydrogel or composite materials, alginates are used together with some additional polymers, such as: poly acrylamide (PAAm) [13], poly(acrylic acid) (PAA) [14], gelatin [15], and chitosan [16], as well as PVA [17]. Poly(vinyl alcohol) is very important and interesting, because it characterized by biocompatibility, biodegradability and non-toxicity due to it is commonly used in the medical and pharmaceutical, such as: artificial organs, drug delivery as well as wound dressings.…”

Section: Introductionmentioning

confidence: 99%

Impact of the Type of Crosslinking Agents on the Properties of Modified Sodium Alginate/Poly(vinyl Alcohol) Hydrogels

Bialik-Wąs

Królicka

2021

Molecules

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Here, we report on studies on the influence of different crosslinking methods (ionic and chemical) on the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin. First, an aqueous extract of Echinacea purpurea was prepared using a Soxhlet apparatus. Next, a series of modified SA/PVA-based hydrogels were obtained through the chemical crosslinking method using poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol) as a crosslinking agent and, additionally, the ionic reaction in the presence of a 5% w/v calcium chloride solution. The compositions of SA/PVA/E. purpurea-based hydrogels contained a polymer of natural origin—sodium alginate (SA, 1.5% solution)—and a synthetic polymer—poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)—in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea—5, 10, 15 or 20% (v/v). Additionally, the release behavior of echinacoside from the polymeric matrix was evaluated in phosphate-buffered saline (PBS) at 37 °C. The results indicate that the type of the crosslinking method has a direct impact on the release profile. Consequently, it is possible to design a system that delivers an active substance in a way that depends on the application.

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“…Hydrogels containing 10% hesperidin were not cytotoxic and strongly promoted cell proliferation. The in vivo tests verified that wound closure was accelerated compared to treatment with bandages ( Bagher et al, 2020 ).…”

Section: Function and Application Of Hydrogel-like Chitosan-based Matmentioning

confidence: 81%

Chitosan-Based Functional Materials for Skin Wound Repair: Mechanisms and Applications

Feng

Luo

et al. 2021

Front. Bioeng. Biotechnol.

295

140

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Skin wounds not only cause physical pain for patients but also are an economic burden for society. It is necessary to seek out an efficient approach to promote skin repair. Hydrogels are considered effective wound dressings. They possess many unique properties like biocompatibility, biodegradability, high water uptake and retention etc., so that they are promising candidate materials for wound healing. Chitosan is a polymeric biomaterial obtained by the deacetylation of chitin. With the properties of easy acquisition, antibacterial and hemostatic activity, and the ability to promote skin regeneration, hydrogel-like functional wound dressings (represented by chitosan and its derivatives) have received extensive attentions for their effectiveness and mechanisms in promoting skin wound repair. In this review, we extensively discussed the mechanisms with which chitosan-based functional materials promote hemostasis, anti-inflammation, proliferation of granulation in wound repair. We also provided the latest information about the applications of such materials in wound treatment. In addition, we summarized the methods to enhance the advantages and maintain the intrinsic nature of chitosan via incorporating other chemical components, active biomolecules and other substances into the hydrogels.

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Wound healing with alginate/chitosan hydrogel containing hesperidin in rat model

Cited by 144 publications

References 49 publications

Chitosan and Cellulose-Based Hydrogels for Wound Management

Chitosan and Cellulose-Based Hydrogels for Wound Management

Impact of the Type of Crosslinking Agents on the Properties of Modified Sodium Alginate/Poly(vinyl Alcohol) Hydrogels

Chitosan-Based Functional Materials for Skin Wound Repair: Mechanisms and Applications

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