Wound healing with nonthermal microplasma jets generated in arrays of hourglass microcavity devices

Park, Chan Hum; Lee, Joong Seob; Kim, Ji Heui; Lee, Ok Joo; Ju, Hyung Woo; Moon, Bo Mi; Cho, Jin Hoon; Kim, Min Hwan; Sun, Peter P.; Park, Sung Jin; Eden, J. G.

doi:10.1088/0022-3727/47/43/435402

Cited by 26 publications

(30 citation statements)

References 18 publications

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“…chronic wounds and cancers. It has been shown through in vitro cell studies and in vivo animal experiments that cold atmospheric plasma, herein referred to as plasma, might accelerate wound healing by stimulation of cell growth and migration [1][2][3][4][5][6][7][8][9][10][11], and also decontaminate infected wounds through targeted destruction of bacterial cells [12][13][14][15][16][17][18][19][20][21][22]. Similar results have been obtained in clinical studies where the efficacy of plasma in wound decontamination and healing has been demonstrated [23][24][25][26].…”

Section: Introductionsupporting

confidence: 56%

“…in cosmetics such as teeth whitening and wrinkle treatment to the destruction of tumours in cancer therapy, it is reasonable to assume that there must be a graduated scale of risk:benefit that warrants consideration. As a simple analogy (that should not be pushed too far), a small exposure to x-rays is acceptable for imaging teeth and should do no harm if performed correctly, whereas higher doses that cause significant cell damage are utilised (specifically for this reason) in targeted cancer therapy 10 .…”

Section: Introductionmentioning

confidence: 99%

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The assessment of cold atmospheric plasma treatment of DNA in synthetic models of tissue fluid, tissue and cells

Szili

Gaur

Hong

et al. 2017

J. Phys. D: Appl. Phys.

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Section: Introductionsupporting

confidence: 56%

Section: Introductionmentioning

confidence: 99%

The assessment of cold atmospheric plasma treatment of DNA in synthetic models of tissue fluid, tissue and cells

Szili

Gaur

Hong

et al. 2017

J. Phys. D: Appl. Phys.

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“…[http://dx.doi.org/10.1063/1.4967880] There is significant optimism that cold atmospheric plasmas might one day be effectively and routinely utilized for targeted cancer therapy, 1-3 wound decontamination [4][5][6][7][8] and wound healing. [9][10][11] The action of plasma jets, usually operated with helium (He) and argon (Ar), is linked to reactive oxygen and nitrogen species (RONS). [12][13][14] RONS are generated upon interaction of the plasma jet with ambient air.…”

mentioning

confidence: 99%

How plasma induced oxidation, oxygenation, and de-oxygenation influences viability of skin cells

Strudwick

Short

et al. 2016

Applied Physics Letters

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The effect of oxidation, oxygenation, and de-oxygenation arising from He gas jet and He plasma jet treatments on the viability of skin cells cultured in vitro has been investigated. He gas jet treatment de-oxygenated cell culture medium in a process referred to as “sparging.” He plasma jet treatments oxidized, as well as oxygenated or de-oxygenated cell culture medium depending on the dissolved oxygen concentration at the time of treatment. He gas and plasma jets were shown to have beneficial or deleterious effects on skin cells depending on the concentration of dissolved oxygen and other oxidative molecules at the time of treatment. Different combinations of treatments with He gas and plasma jets can be used to modulate the concentrations of dissolved oxygen and other oxidative molecules to influence cell viability. This study highlights the importance of a priori knowledge of the concentration of dissolved oxygen at the time of plasma jet treatment, given the potential for significant impact on the biological or medical outcome. Monitoring and controlling the dynamic changes in dissolved oxygen is essential in order to develop effective strategies for the use of cold atmospheric plasma jets in biology and medicine.

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“…This information is also useful if microplasma arrays are used in the treatment of solutions or biological material. For examples, microplasma arrays are currently being evaluated in the sterilization of surfaces [63,64], the decontamination of water [65] and in the stimulation of wound healing through the plasma-induced modification of biomolecules [39,66].…”

Section: Detection Of Rons In Solutionmentioning

confidence: 99%

Microplasma Array Patterning of Reactive Oxygen and Nitrogen Species onto Polystyrene

Szili

Dedrick

et al. 2017

Front. Phys.

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We investigate an approach for the patterning of reactive oxygen and nitrogen species (RONS) onto polystyrene using atmospheric-pressure microplasma arrays. The spectrally integrated and time-resolved optical emission from the array is characterized with respect to the applied voltage, applied-voltage frequency and pressure; and the array is used to achieve spatially resolved modification of polystyrene at three pressures: 500, 760, and 1000 Torr. As determined by time-of-flight secondary ion mass spectrometry (ToF-SIMS), regions over which surface modification occurs are clearly restricted to areas that are exposed to individual microplasma cavities. Analysis of the negative-ion ToF-SIMS mass spectra from the center of the modified microspots shows that the level of oxidation is dependent on the operating pressure, and closely correlated with the spatial distribution of the optical emission. The functional groups that are generated by the microplasma array on the polystyrene surface are shown to readily participate in an oxidative reaction in phosphate buffered saline solution (pH 7.4). Patterns of oxidized and chemically reactive functionalities could potentially be applied to the future development of biomaterial surfaces, where spatial control over biomolecule or cell function is needed.

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Wound healing with nonthermal microplasma jets generated in arrays of hourglass microcavity devices

Cited by 26 publications

References 18 publications

The assessment of cold atmospheric plasma treatment of DNA in synthetic models of tissue fluid, tissue and cells

The assessment of cold atmospheric plasma treatment of DNA in synthetic models of tissue fluid, tissue and cells

How plasma induced oxidation, oxygenation, and de-oxygenation influences viability of skin cells

Microplasma Array Patterning of Reactive Oxygen and Nitrogen Species onto Polystyrene

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