Wound Infection and Biofilms

McCarty, Sara; Jones, Erica; Finnegan, Simon; Woods, Emma; Cochrane, Christine A.; Percival, Steven L.

doi:10.1016/b978-0-12-397043-5.00018-9

Cited by 6 publications

(9 citation statements)

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“…The cost of infection in CLUs can be significant because they increase a patient's expenditure and healthcare-related consumption, as well as many other indirect costs (Green et al, 2014;Sen et al, 2009). Infections in chronic wounds have a major contribution to the increase in direct and indirect healthcare expenditure for the healthcare system (Graves & Zheng, 2014;Guest, Fuller, & Vowden, 2018;McCarty et al, 2014). These expenditures include the increased number of patients being admitted to hospital, additional healthcare-related costs and increased pressure on healthcare providers (Australian Wound Management Association, 2011;Drew et al, 2007).…”

Section: Backg Rou N Dmentioning

confidence: 99%

Validation of predictive factors for infection in adults with chronic leg ulcers: A prospective longitudinal study

Bui

Finlayson

Edwards

2020

Journal of Clinical Nursing

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Aims and objectives To validate the ability of factors to predict infection in adults with chronic leg ulcers over a 12‐week period. Background Leg ulcers affect ~3% of older adults and are often hard to heal. Infection is a leading contributor for delayed healing, causing delayed wound healing, increased hospitalisation, increased healthcare costs and reduced patient quality of life. The importance of early identification of infection has been highlighted for decades, yet little is known about factors that are associated with increased risk of infection in this specific population. Design A longitudinal, prospective observational study in a single centre. Methods Between August 2017 and May 2018, a total of 65 adults with chronic leg ulcers were prospectively observed for a 12‐week period. Patients were recruited from an outpatient wound clinic at a tertiary hospital in Australia. Data were collected from recruitment (baseline) and each visit (weekly or fortnightly) up until 12 weeks. Descriptive statistics were calculated for all variables. A Cox proportional hazards regression model was used to identify predictive factors for infection. The TRIPOD guidelines for reporting were followed (See Data S1). Results The sample consisted of 65 adults with chronic leg ulcers, and 9.2% of these had their ulcer infected at baseline. Two predictive factors, using walking aids and gout, were found to be significantly related to increased likelihood of developing infection within 12 weeks. Conclusion The present study showed that patients who either used walking aids or were diagnosed with gout were at greater risk of infection compared to those without these factors. Relevance to clinical practice These findings provide new information for clinicians in early identification of patients at risk of infection, and for patients in enhancing their awareness of their own risk.

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Section: Backg Rou N Dmentioning

confidence: 99%

Validation of predictive factors for infection in adults with chronic leg ulcers: A prospective longitudinal study

Bui

Finlayson

Edwards

2020

Journal of Clinical Nursing

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“…These infections are caused by an array of different microorganisms including bacteria, protozoa, fungi, yeasts, and viruses. The prevention of infections, and reduction or elimination of an infection once it is established is of importance, 6 particularly in the area of skin and wound care. Environments that increase a patient's risk to infection include the surfaces of objects (internally and externally), fluids and fluid conduits.…”

Section: Translational Relevancementioning

confidence: 99%

EDTA: An Antimicrobial and Antibiofilm Agent for Use in Wound Care

Finnegan

Percival

2015

Advances in Wound Care

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198

141

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“…The polymer was then dissolved in ethanol and the lower molar mass fraction was removed using ultra-filtration through a 10 000 g mol −1 molar mass cut off membrane. 1…”

Section: Highly-branched Polymer (Hb-pnipam)mentioning

confidence: 99%

“…Biofilm formation is central to the colonisation of materials and tissues by infective bacteria. 1 The adhesion of bacterial cells to surfaces (whether biotic or abiotic) is the initial stage of formation of biofilms, 2 which are bacterial communities attached to a surface encased in a biopolymer matrix. 3 It is estimated that 80% of all clinical infections are biofilm related 4 and the particular clinical problem they pose is their high levels of antimicrobial non-responsiveness compared with planktonic bacteria.…”

Section: Introductionmentioning

confidence: 99%

Antibiotic functionalised polymers reduce bacterial biofilm and bioburden in a simulated infection of the cornea

et al. 2018

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Microbial keratitis can arise from penetrating injuries to the cornea. Corneal trauma promotes bacterial attachment and biofilm growth, which decrease the effectiveness of antimicrobials against microbial keratitis. Improved therapeutic efficacy can be achieved by reducing microbial burden prior to antimicrobial therapy. This paper assesses a highly-branched poly(N-isopropyl acrylamide) with vancomycin end groups (HB-PNIPAM-van), for reducing bacterial attachment and biofilm formation. The polymer lacked antimicrobial activity against Staphylococcus aureus, but significantly inhibited biofilm formation (p = 0.0008) on plastic. Furthermore, pre-incubation of S. aureus cells with HB-PNIPAM-van reduced cell attachment by 50% and application of HB-PNIPAM-van to infected ex vivo rabbit corneas caused a 1-log reduction in bacterial recovery, compared to controls (p = 0.002). In conclusion, HB-PNIPAM-van may be a useful adjunct to antimicrobial therapy in the treatment of corneal infections.

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Wound Infection and Biofilms

Cited by 6 publications

References 50 publications

Validation of predictive factors for infection in adults with chronic leg ulcers: A prospective longitudinal study

Validation of predictive factors for infection in adults with chronic leg ulcers: A prospective longitudinal study

EDTA: An Antimicrobial and Antibiofilm Agent for Use in Wound Care

Antibiotic functionalised polymers reduce bacterial biofilm and bioburden in a simulated infection of the cornea

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