Wound-only injection of rabies immunoglobulin (RIG) saves lives and costs less than a dollar per patient by “pooling strategy”

Bharti, Omesh Kumar; Thakur, Baldev; Rao, Ranjna

doi:10.1016/j.vaccine.2019.07.087

Cited by 21 publications

(22 citation statements)

References 8 publications

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“…We advised him to defer COVID-19 vaccine for 7 days and take 3 doses of rabies vaccination (RV), as per the schedule, on the 0, 3rd, and 7th days along with wound infiltration with Equine Rabies Immunoglobulins (ERIG). 3 He did the same and is fine.…”

Section: Date Of Submissionmentioning

confidence: 95%

Can Rabies Vaccines be given with or after COVID-19 Vaccines and Vice Versa?

Bharti

2021

EpidemInt

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Section: Date Of Submissionmentioning

confidence: 95%

Can Rabies Vaccines be given with or after COVID-19 Vaccines and Vice Versa?

Bharti

2021

EpidemInt

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“…This finding is encouraging, as RIG is in short supply in many LMICs [16,75,76,81,84,88]. A study in India established that rabies monoclonal antibodies are equally as safe and effective [89] and the WHO changed its position to recommend only infiltration of RIG at the wound site without further intramuscular injection of the remainder [84,90].…”

Section: Outcome 13 Human Rabies Is Preventable By Timely Access To Pepmentioning

confidence: 97%

Human rabies: prospects for elimination

et al. 2021

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Almost half of all countries in the world are effectively free of human deaths from dog-mediated rabies. But the disease still affects people in low- and middle-income countries, especially the rural poor, and children. Successful regional elimination of human rabies is attributable to advances in significant and sustained investment in dog vaccination, post-exposure vaccination and surveillance, illustrated by productive efforts to reduce human rabies in Latin America over the last 35 years. Nonetheless, countries still facing endemic rabies face significant barriers to elimination. Using the 2017 Global Strategic Plan to end human rabies deaths from dog-mediated rabies by 2030 as a reference point and an organizing framework, we assess progress toward global rabies elimination by examining the characteristics of successful regional control efforts and barriers to elimination. Although substantive barriers exist for countries where rabies remains endemic, advances in knowledge, technology, institutions, and economics provide a basis for optimism.

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“…1). Out of these 35 included studies, 25 reported epidemiological outcomes only: 19 cross-sectional studies, 4,20-39 3 cohort studies (2 prospective cohort 40,41 and 1 retrospective cohort studies 42 ) and 1 modeling study. 43 Nine studies reported economic outcomes only [44][45][46][47][48][49][50][51][52] and all of these studies were partial economic evaluation (2 prospective cohort studies, 51,52 6 cross-sectional studies [44][45][46][48][49][50] and 1 on implementation cost of interventions 47 ).…”

Section: Search and Screeningmentioning

confidence: 99%

“…Only one modeling study reported all the three outcomes: epidemiological, economic and humanistic. 1 Out of 35 included studies, 23 were hospital (or clinic) based, [20][21][22][24][25][26][27][28][29][30][31]38,41,42,[44][45][46][47][48][49][50][51][52] 9 were community (or household) based 4,23,[32][33][34][35]37,39,40 and 2 were modeling studies at country level 1,43 and was laboratory-based study. 36…”

Section: Search and Screeningmentioning

confidence: 99%

Burden of illness of dog-mediated rabies in India: A systematic review

John

Royal

Bharti

2021

Clinical Epidemiology and Global Health

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India accounts for 35% of global burden of rabies. This systematic review attempts to measure the burden of illness of dog bites and dog-mediated rabies in India. Methods: A systematic literature search was conducted on MEDLINE, EMBASE, Cochrane Central, PROQUEST, Sodhganga and Google Scholar. Two independent reviewers screened titles and abstracts and included full texts as per inclusion criteria. Critical appraisal of included studies was conducted using appropriate checklists. Data was extracted using standardized data extraction tools, analyzed and reported in narrative summary and tabular formats.Results: 35 studies were included for narrative synthesis after screening for inclusion criteria. The annual crude dog bite incidence was reported between 0.26% and 2.5% with stray dogs as main biting animal. The bites were mainly reported in males, between age group 10-40 years, individuals belonging to low socio-economic status and people working in fields. The annual economic and humanistic burden is estimated to be 2.85 million USD and 1.3 million DALYs respectively. Use of intradermal route of vaccination and equine rabies immunoglobulins has been reported to save cost and resources over use of intramuscular route of vaccination and human rabies immunoglobulins. Conclusion:The review highlighted the burden of disease at local, regional and national level. There has been dearth of studies reporting economic and humanistic burden at national level. Systematic review registration: PROSPERO ID: CRD42020213261.

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Wound-only injection of rabies immunoglobulin (RIG) saves lives and costs less than a dollar per patient by “pooling strategy”

Cited by 21 publications

References 8 publications

Can Rabies Vaccines be given with or after COVID-19 Vaccines and Vice Versa?

Can Rabies Vaccines be given with or after COVID-19 Vaccines and Vice Versa?

Human rabies: prospects for elimination

Burden of illness of dog-mediated rabies in India: A systematic review

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