Wound treatment on a diabetic rat model by a 808 nm diode laser

Lau, Pik Suan; Bidin, Noriah; Krishnan, Ganesan; AnaybBaleg, Sana Mohammed; Marsin, Faridah Mohd; Sum, Mohamad Bin Md; Baktiar, Harzi; Nassir, Zaleha; Chong, Pek Lian; Hamid, Asmah

doi:10.1088/1054-660x/25/7/075601

Cited by 9 publications

(6 citation statements)

References 34 publications

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“…They hypothesize that NIR light can penetrate into deep tissue injury, which induces the unwounded keratinocytes and endothelial cells in the surrounding skin to migrate into the wounded area for tissue repair. The effectiveness of 808 nm laser in our study also agrees well with previous reports [29,30] of beneficial effects to shorten the inflammatory phase, accelerate the remodeling and promote re-epithelization in the wound healing process.…”

Section: Discussionsupporting

confidence: 92%

Wavelength and dose-dependent effects of photobiomodulation therapy on wound healing in rat model

et al. 2018

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Photobiomodulation therapy (PBMT) is the use of near infrared light to stimulate tissue repair in the healing process. The aim of this study was to evaluate the wavelength-and dosedependent effects of PBMT on wound healing.Thirty-six Sprague Dawley rats with four circular full thickness 6 mm diameter cutaneous wounds each were distributed into experimental part 1 for optimization of wavelengths on wound treatment and experimental part 2 for dose-dependent studies. In part 1, various near infrared laser wavelengths (808, 880 and 1064 nm) were used as PBMT light source to optimize the wound treatment under the same fluence of 5 J cm −2 . Furthermore, the optimal wavelength was selected as treatment source in part 2 with various power densities in the range of 20-100 mW cm −2 . All wounds were treated immediately except for the control group and the experiment was conducted for nine consecutive days.The result in part 1 showed that 808 nm was the optimal wavelength to give the highest wound closure percentage at 94.08% ± 6.5%, meanwhile power density of 40-60 mW cm −2 better accelerated the healing rate than other groups in part 2.Therefore, PBMT using 808 nm at the range of 40-60 mW cm −2 has beneficial effects on the wound healing process.

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Section: Discussionsupporting

confidence: 92%

Wavelength and dose-dependent effects of photobiomodulation therapy on wound healing in rat model

et al. 2018

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“…Every single variation of each parameter results in different outcomes, and either inhibitory or stimulatory effects in wound healing. Most present studies only emphasize the energy density and total fluencies [14][15][16]; thus, there is a lack of studies that emphasize the effect of different power densities with the same fluencies. Therefore, this study aims to investigate the interaction of two different low power densities, i.e.…”

Section: Introductionmentioning

confidence: 99%

Influence of low power density on wound healing in streptozotocin-induced diabetic rats

Lau¹,

Bidin²,

Islam³

et al. 2017

Laser Phys.

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Photobiomodulation therapy (PBMT) is used for wound healing at two different power densities, i.e. 0.2 W cm −2 and 0.4 W cm −2 , while maintaining the same fluence of 5 J cm −2 . Forty-five streptozotocin (STZ)-induced diabetic rats were allocated into three groups: the untreated laser group (G0), 0.2 W cm −2 laser treated group (GL1), and 0.4 W cm −2 laser treated group (GL2). Six mm full thickness cutaneous wounds are created on the dorsal side of rats. A 808 nm diode laser irradiates the wound in GL1 and GL2 daily for 9 consecutive days. Groups GL1 and GL2 have the same total fluence but different power densities, 0.2 W cm −2 and 0.4 W cm −2 , which results in stimulatory and inhibitory effects in wound healing, respectively. In group GL1, enhanced wound contraction and inflammation has been triggered at an earlier stage compared to the untreated laser group G0. Meanwhile, the laser treated group GL2 exhibits an escalated volume of inflammatory cells, and collagen synthesis is inhibited. Therefore, it can be concluded that PBMT has potential in promoting wound healing under the low power density (0.2 W cm −2 ) condition.

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“…Previous research has investigated the efficacy of acupuncture in the treatment of CIR injury in rats [8]. A semiconductor laser has the required characteristics for laser acupoint irradiation therapy: deep tissue penetration, and is therefore the preferred choice for this therapy [9,10]. Transcranial low-level light therapy has gained interest as a non-invasive, inexpensive and safe method of modulating neurological and psychological functions in recent years [11].…”

Section: Discussionmentioning

confidence: 99%

Effects of laser acupoint irradiation on energy metabolism of brain tissue of rats with cerebral ischemia-reperfusion

Xiong¹,

Li²

2017

Laser Phys.

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The protective effect and mechanism of low-intensity laser acupoint irradiation on focal cerebral ischemia-reperfusion (CIR) injury in rats were investigated. Male Sprague-Dawley rats were randomly divided into a sham group, a CIR model (model) group, and a model plus laser irradiation (laser) group. The focal CIR model was induced by middle cerebral artery occlusion in all except the rats in the sham group. After modeling, the Baihui, Mingmen, and left Zusanli points of the rats in the laser group were irradiated with 15 mW using a semiconductor laser, and each point was irradiated for 15 min once a day for 7 d. The treatments used in the sham and model groups were the same as in the laser group except that the laser output power was zero. After treatment, the expressions of serum superoxide dismutase (SOD) activity and serum malonaldehyde (MDA) content, the expression of growth-associated protein (GAP-43), the activities of succinic dehydrogenase and lactic dehydrogenase in brain tissue, were measured. The results showed that acupoint irradiation with a semiconductor laser can improve energy metabolism, enhance the expression of GAP-43, increase the levels of expression of serum SOD, and decrease the serum MDA content in a rat model of focal CIR, suggesting the mechanism for reduction of CIR injury.

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Wound treatment on a diabetic rat model by a 808 nm diode laser

Cited by 9 publications

References 34 publications

Wavelength and dose-dependent effects of photobiomodulation therapy on wound healing in rat model

Wavelength and dose-dependent effects of photobiomodulation therapy on wound healing in rat model

Influence of low power density on wound healing in streptozotocin-induced diabetic rats

Effects of laser acupoint irradiation on energy metabolism of brain tissue of rats with cerebral ischemia-reperfusion

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