Wpływ stopnia modyfikacji mezoporowatej krzemionki SBA-15 na proces adsorpcji sulindaku

Dadej, Adrianna; Geszke-Moritz, Małgorzata; Moritz, Michał; Jelińska, Anna

doi:10.15199/62.2019.7.13

Cited by 1 publication

(4 citation statements)

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“…Our previous studies confirmed the ability of an SBA-15-modified material to adsorb sulindac [ 18 ]. The aim of this study was to analyze the modification of sulindac release profiles from SBA-15-functionalized silicas.…”

Section: Introductionsupporting

confidence: 85%

“…We obtained the SBA-15 materials in accordance with the previously presented report [ 18 ]. We adapted the methodology presented by Zhao with modifications [ 8 ].…”

Section: Methodsmentioning

confidence: 99%

“…The precipitate was air dried. The obtained material was designated as SBA-15-A 0.05 :SUL and SBA-15-A 0.20 :SUL [ 18 ].…”

Section: Methodsmentioning

confidence: 99%

“…The amount of adsorbed SUL was calculated as the difference in the concentrations of the solutions before and after adsorption using a UV/VIS LAMBDA 20 Perkin Elmer spectrophotometer (PerkinElmer, Inc., Waltham, MA, USA) at 396 nm. The amount of SUL adsorbed in SBA-15-A 0.05 and SBA-15-A 0.20 was 90.5 mg/g and 221.3 mg/g, respectively [ 18 ].…”

Section: Methodsmentioning

confidence: 99%

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Modification of the Release of Poorly Soluble Sulindac with the APTES-Modified SBA-15 Mesoporous Silica

et al. 2021

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The effectiveness of oral drug administration is related to the solubility of a drug in the gastrointestinal tract and its ability to penetrate the biological membranes. As most new drugs are poorly soluble in water, there is a need to develop novel drug carriers that improve the dissolution rate and increase bioavailability. The aim of this study was to analyze the modification of sulindac release profiles in various pH levels with two APTES ((3-aminopropyl)triethoxysilane)-modified SBA-15 (Santa Barbara Amorphous-15) silicas differing in 3-aminopropyl group content. Furthermore, we investigated the cytotoxicity of the analyzed molecules. The materials were characterized by differential scanning calorimetry, powder X-ray diffraction, scanning and transmission electron microscopy, proton nuclear magnetic resonance and Fourier transformed infrared spectroscopy. Sulindac loaded on the SBA-15 was released in the hydrochloric acidic medium (pH 1.2) and phosphate buffers (pH 5.8, 6.8, and 7.4). The cytotoxicity studies were performed on Caco-2 cell line. The APTES-modified SBA-15 with a lower adsorption capacity towards sulindac released the drug in a less favorable manner. However, both analyzed materials improved the dissolution rate in acidic pH, as compared to crystalline sulindac. Moreover, the SBA-15, both before and after drug adsorption, exhibited insignificant cytotoxicity towards Caco-2 cells. The presented study evidenced that SBA-15 could serve as a non-toxic drug delivery system that enhances the dissolution rate of sulindac and improves its bioavailability.

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Section: Introductionsupporting

confidence: 85%

“…We obtained the SBA-15 materials in accordance with the previously presented report [ 18 ]. We adapted the methodology presented by Zhao with modifications [ 8 ].…”

Section: Methodsmentioning

confidence: 99%

“…The precipitate was air dried. The obtained material was designated as SBA-15-A 0.05 :SUL and SBA-15-A 0.20 :SUL [ 18 ].…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations