Wpływ występowania allelu klasy III VNTR genu INS na parametry auksologiczne, stężenie glukozy, insuliny, lipidów i adipocytokin u przeddojrzewaniowych dzieci urodzonych z niską masą ciała

Abstract

Introduction:The insulin gene variable number of tandem repeats (INS VNTR) class III allele has been implicated in lower birth weight, obesity, and insulin resistance. We assessed its influence on birth weight in the Polish population and on the current body mass and metabolic profile in prepubertal children born small for gestational age (SGA). Material and methods: DNA for genotyping of INS VNTR was available for 123 subjects born SGA and 132 born appropriate for gestational age (AGA). We identified two alleles: class I and class III. Next, in 112 prepubertal (aged: 6.8 ± 1.38 years) SGA children, the auxological measurements, fasting serum C-peptide, triglycerides, cholesterol, ghrelin, leptin, adiponectin, resistin, cortisol, and insulin-like growth factor type I (IGF-I) concentrations, as well as glucose and insulin during oral glucose tolerance test (OGTT), were assessed and insulin resistance indices were calculated. The results were analysed depending on INS VNTR variants. Results: The occurrence of individual INS VNTR variants were similar in the SGA and AGA groups. In prepubertal SGA children, we did not observe any statistical differences as regards birth weight, body mass, lipids, or adipocytokine concentrations among I/I, I/III, and III/III class groups. The concentration of insulin in 120' of OGTT was significantly higher in class III homozygous than in class I homozygous individuals. Conclusions: Variant INS VNTR class III was shown not to be associated in any essential way with birth weight in the Polish population. Among prepubertal SGA children, the presence of INS VNTR class III is related to higher insulin secretion during OGTT. (Endokrynol Pol 2016; 67 (6): 585-591)

Study on the Effect and Mechanism of Huaji Jianpi Decoction on Simple Obesity

“…SOCS3, JAK2, STAT3, and LEPRB in module 3 ( Figure 8(b) ) are components of the JAK2-STAT3 pathway. Reportedly, INS and LEP are closely related to obesity [ 19 , 20 ], while PTPN11 was identified in the studies of histiocytic sarcoma and Noonan syndrome [ 21 ].…”

Polish Journal of Veterinary Sciences

“…It is believed that ketosis in dairy cows is caused by negative energy balance (NEB), the disorder in glucose and lipid metabolism, high concentration of non-esterified fatty acid (NEFA), β-hydroxybutyric acid (BHBA), and insulin resistance (IR) (Li et al 2014, Ježek et al 2017. Adipokines regulate oxidative stress, inflammatory response and energy balance by influencing insulin sensitivity and regulating glucose and lipid metabolism (Yu-Duan et al 2013, Stawerska et al 2016, indicating that NEB is closely associated with ketosis in dairy cows. Recently, researchers found that adiponectin (ADP) and leptin (LEP) play important roles in regulation of energy balance, INS sensitivity and appetite (López-Jaramillo et al 2014).…”