This study presents a novel reverse measurement, CAD/CAM, and practical machining of conjugate cams on a computer-numerical-controlled (CNC) machine. This paper consists of five main components: a novel reverse measurement, displacement curve equations, CAD/CAM, practical machining and tests of the conjugate cams in a diesel engine. The diesel engine can output the 13-horse power and the rotational speed of 3500 rpm at the maximum. The results reveal that the torque and power are in good agreement between the reverse and the original conjugate cams in a diesel engine.