Wrightia tinctoria R. Br.-a review on its ethnobotany, pharmacognosy and pharmacological profile

doi:10.12980/jclm.2.2014c1221

Cited by 5 publications

(4 citation statements)

References 47 publications

(43 reference statements)

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“…Notably, commercially available seeds of Wrightia tinctoria showed evidence of compounds that are identified with high confidence as PAs (Table 2). Seeds of Wrightia tinctoria are consumed in Ayruveda and other medicinal traditions of India, both intentionally (Khyade, 2014), and as contaminants of Holarrhena pubescens seeds (Khan, 1987). We found contamination by Wrightia tinctoria in our purchased package of Holarrhena pubescens seeds.…”

Section: Implications For Human Healthmentioning

confidence: 69%

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Chemotaxonomic Investigation of Apocynaceae for Retronecine-Type Pyrrolizidine Alkaloids Using HPLC-MS/MS

Barny

Tasca

Sánchez

et al. 2020

Preprint

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Apocynaceae are well-known for diverse specialized metabolites that are distributed in a phylogenetically informative manner. Pyrrolizidine alkaloids (PAs) have been reported sporadically in one lineage in the family, the APSA clade, but few species had been studied to date. We conduct the first systematic survey of Apocynaceae for retronecine-type PAs, sampling leaves from 231 species from 13 of 16 major lineages within the APSA clade using HPLC-MS/MS. We also follow up on preliminary evidence for infra-specific variation of PA detectability in Echites umbellatus Jacq. Four precursor ion scans (PREC) were developed for a high-throughput survey for chemicals containing a structural moiety common to many PAs, the retronecine core. We identified with high confidence PAs in 7 of 8 sampled genera of tribe Echiteae, but not in samples from the closely related Odontadenieae and Mesechiteae, confirming the utility of PAs as a taxonomic character in tribal delimitation. The presence of PAs in Malouetieae was confirmed, as we report with high confidence their presence in Galactophora schomburgkiana Woodson and Eucorymbia alba Stapf, but currently we have low confidence of their presence in Holarrena pubescens Wall. ex G. Don (the one Malouetieae species where they were previously reported), as well as in Kibatalia macrophylla (Pierre ex Hua) Woodson and in Holarrena curtisii King & Gamble. For the first time the presence of PAs in species of Wrightia R. Br. (Wrightieae) and Marsdenia R. Br. (Marsdenieae) was confirmed. Detectability of PAs was found to vary among samples of Echites umbellatus and intra-individual plasticity contributes to this variation. Of toxicological importance, novel potential sources of human exposure to pro-toxic PAs were identified in the medicinal plants, Wrightia tinctoria R.Br. and Marsdenia tinctoria R.Br., and the food plant, Echites panduratus A. DC., warranting immediate further research to elucidate the structures of the candidate PAs identified. Method development and limitations are discussed.

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Section: Implications For Human Healthmentioning

confidence: 69%

“…This species is sampled here (Table S1) (Ngan, 1965), and the indole-containing compounds indigotin and indirubin are known from W. tinctoria, as well as the quinolizidine, tryptanthrin (Khyade, 2014). Two of these three species, W. tinctoria and W. dubia, are here reported as likely containing PAs (Table 2) while the third, W.…”

Section: Wrightieaementioning

confidence: 91%

Chemotaxonomic Investigation of Apocynaceae for Retronecine-Type Pyrrolizidine Alkaloids Using HPLC-MS/MS

Barny

Tasca

Sánchez

et al. 2020

Preprint

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“…has a high level of antioxidants so people on the island of Moa use it for the treatment of malaria, and diabetes and to increase immunity. This is to the results of research by Khyade et al (2014), regarding A. scholaris and A. macrophylla for the treatment of malaria, jaundice, digestive disorders, and cancer. Due to the leaf morphology of Alstonia sp.…”

Section: Discussionmentioning

confidence: 98%

“…The chemical constituents of these plants are Alkaloids, phlorotannins, simple phenolics, steroids, saponins, and tannins have been reported in all parts of Alstonia scholaris (Khyade et al, 2014;Otuu et al, 2021). This provides an opportunity to develop this plant as a nutraceutical that is beneficial for health and has economic value for the community.…”

Section: Introductionmentioning

confidence: 98%

Antioxidant and Antimalarial Potential of Methanolic Extract from Leaves of Titi Tree (Alstonia sp)

Nindatu,

Kaihena,

Hieriej

et al. 2023

jppipa, pendidikan ipa, fisika, biologi, kimia

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Alstonia sp leaves extract has previously been reported as a potential antimalarial drug as traditional. This study aims to analyze the antimalarial activity and determine the antioxidant potential of titi tree leaves (Alstonia sp). The method used in this research is a modified method of "4 Days Suppressive Test" which was originally described by Peter with different doses (0.55 g/kg, 0.65 g/kg and 0.75 g/kg body weight) of methanol extract of leaves of Titi tree (Alstonia sp) was administered orally to albino mice. Antioxidants were analyzed using a spectrophotometer. The Leaves of Alstonia sp has antimalarial activity and contains potential antioxidant activity with an IC50 value of 70.12 ppm for leaves (strong category). The dose of 0.75 g has a better effect compared to the other effects because it lowers the level of parasitemia more strongly. So that the leaves of Alstonia sp. pressured to be developed as a nutraceutical.

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Bioaccumulation of industrial heavy metals and interactive biochemical effects on two tropical medicinal plant species

Mandal

Dhal²

2023

Environ Sci Pollut Res

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Concentrations of heavy metals (Cr, Cu, Fe, Mn, Ni, Pb, and Zn) accumulation were studied in the leaves of two medicinal plant species, namely Holarrhena pubescens, and Wrightia tinctoria, from two industrial areas and a control area. Our comparison study revealed that industrialization signi cantly increased the accumulation of heavy metals in both plant species. A comparison study in control and industrial areas exhibited that heavy metal accumulation was higher in the industrially affected area than in the control area. In the control area, both species accumulated the lowest heavy metal concentration. Where heavy metals concentration exceeded the permissible limit recommended by the WHO in both species of two industrial areas. Biochemical investigation speci es that in response to heavy metals accumulation, both species increased the activity of hydrogen peroxide (H 2 O 2 ), malondialdehyde (MDA) content, the activity of enzymatic [superoxide dismutase(SOD) and peroxidase (POD)] and nonenzymatic [ascorbic acid (AsA)] antioxidant, but decreased the primary (soluble carbohydrate and total protein), secondary metabolites (phenol and avonoid) content and free radical scavenging (DPPH) activity. These study indicate that industrialization potentially harms medicinal plants by reducing the e cacy of their medicinal property.

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Wrightia tinctoria R. Br.-a review on its ethnobotany, pharmacognosy and pharmacological profile

Cited by 5 publications

References 47 publications

Chemotaxonomic Investigation of Apocynaceae for Retronecine-Type Pyrrolizidine Alkaloids Using HPLC-MS/MS

Chemotaxonomic Investigation of Apocynaceae for Retronecine-Type Pyrrolizidine Alkaloids Using HPLC-MS/MS

Antioxidant and Antimalarial Potential of Methanolic Extract from Leaves of Titi Tree (Alstonia sp)

Bioaccumulation of industrial heavy metals and interactive biochemical effects on two tropical medicinal plant species

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