Wrist Actigraphy in Insomnia

Hauri, Peter; Wisbey, Joyce

doi:10.1093/sleep/15.4.293

Cited by 290 publications

(149 citation statements)

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“…Actigraphy measurements of rest -activity cycles A watch-like wrist actigraph (Ambulatory Monitoring, Inc., AMI), worn on the nondominant wrist, was used to record a patient's movement pattern over a 4 -7-day period (Hauri and Wisbey, 1992;Hilliker et al, 1992). Patients at VAMC had all activity measurements performed in the week prior to therapy in the ambulatory/home setting.…”

Section: Procedures and Summary Of Measurement Toolsmentioning

confidence: 99%

Circadian function in patients with advanced non-small-cell lung cancer

et al. 2005

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This study aimed to evaluate whether patients with advanced non-small-cell lung cancer experience disrupted rest -activity daily rhythms, poor sleep quality, weakness, and maintain attributes that are linked to circadian function such as fatigue. This report describes the rest -activity patterns of 33 non-small-cell lung cancer patients who participated in a randomised clinical trial evaluating the benefits of melatonin. Data are reported on circadian function, health-related quality of life (QoL), subjective sleep quality, and anxiety/depression levels prior to randomisation and treatment. Actigraphy data, an objective measure of circadian function, demonstrated that patients' rest -activity circadian function differs significantly from control subjects. Our patients reported poor sleep quality and high levels of fatigue. Ferrans and Powers QoL Index instrument found a high level of dissatisfaction with healthrelated QoL. Data from the European Organization for Research and Treatment for Cancer reported poor capacity to fulfil the activities of daily living. Patients studied in the hospital during or near chemotherapy had significantly more abnormal circadian function than those studied in the ambulatory setting. Our data indicate that measurement of circadian sleep/activity dynamics should be accomplished in the outpatient/home setting for a minimum of 4 -7 circadian cycles to assure that they are most representative of the patients' true condition. We conclude that the daily sleep/activity patterns of patients with advanced lung cancer are disturbed. These are accompanied by marked disruption of QoL and function. These data argue for investigating how much of this poor functioning and QoL are actually caused by this circadian disruption, and, whether behavioural, light-based, and or pharmacologic strategies to correct the circadian/sleep activity patterns can improve function and QoL.

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Section: Procedures and Summary Of Measurement Toolsmentioning

confidence: 99%

Circadian function in patients with advanced non-small-cell lung cancer

et al. 2005

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“…The algorithm has been validated by comparing wrist actigraphy and polysomnographic recordings. 9,10,17 In our study, the following parameters were evaluated: 1) time in bed, duration of the period of time lying in bed for sleeping purposes, confirmed by event recordings and data from the light channel; 2) sleep efficiency, ratio between sleeping time and time in bed expressed as a percentage; 3) number of awakenings, number of episodes of awakening during time in bed; 4) wake after sleep onset, time awake after the start of sleeping time. The values were calculated averaging 4 nights (Monday to Friday).…”

Section: Wrist Actigraphymentioning

confidence: 99%

“…The analysis of the periods of rest and activity provides a reasonable estimation of the time spent asleep and awake. 9,10 Although less precise than polysomnography, actigraphy has the advantage of monitoring subjects while they perform their customary social activities, avoiding the constraints of the sleep laboratory. Assessment of activity over several 24-hour periods helps to identify circadianrelated factors that may contribute to the development of sleep disturbance.…”

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confidence: 99%

High prevalence of sleep disturbance in cirrhosis

et al. 1998

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Sleep disturbance is a classic sign of hepatic encephalopathy. However, there are limited data regarding its prevalence in cirrhotic patients without overt hepatic encephalopathy. We assessed the characteristics of sleep in cirrhosis using a sleep questionnaire (n ‫؍‬ 44) and actigraphy (n ‫؍‬ 20). The results were compared with those of subjects with chronic renal failure and those of healthy controls. Presence of subclinical hepatic encephalopathy, chronotypology profile, and individual's affective state were also analyzed. The questionnaire indicated an elevated number of cirrhotic patients (47.7%) and patients with chronic renal failure (38.6%) who complained of unsatisfactory sleep compared with healthy controls (4.5%, P F .01). Actigraphy corroborated the deterioration of sleep parameters in cirrhotic patients with unsatisfactory sleep. The sleep disturbance in cirrhosis was not associated with clinical parameters nor with cognitive impairment. Cirrhotic subjects and patients with chronic renal failure with unsatisfactory sleep showed higher scores for depression and anxiety, raising the possibility that the effects of chronic disease may underlie the pathogenesis of sleep disturbance. However, in contrast to chronic renal failure, unsatisfactory sleep in cirrhosis was associated with delayed bedtime, delayed wake-up time, and evening chronotypology. In conclusion, a sleep disturbance is frequent in cirrhotic patients without hepatic encephalopathy and may be related to abnormalities of the circadian timekeeping system. (HEPATOLOGY 1998;27:339-345.)A disturbance of sleep is recognized as one of the early signs of hepatic encephalopathy. 1 However, there are limited data regarding its prevalence in patients with cirrhosis without signs of overt hepatic encephalopathy. Results from a quality of life questionnaire indicated that disturbance in sleep was significantly higher in nonalcoholic cirrhotic patients compared with subjects with another chronic illness, such as Crohn' s disease. 2 In this survey and subsequent data, 3 up to 35% of cirrhotic individuals had difficulties in the area of sleep and rest.The mechanisms responsible for these findings are poorly understood. One possibility is that abnormalities in circadian function may underlie its pathogenesis. The sleep-wake cycle is one of the functions regulated by the circadian clock, the suprachiasmatic nucleus of the anterior hypothalamus, 4 which has efferent connections that influence a large array of biological functions including the secretion of melatonin from the pineal gland. Previous studies from our laboratory have shown that rats subjected to a portacaval anastomosis experience an alteration in the rhythm of circadian locomotor activity as well as the rhythm of pineal melatonin content. 5 In patients with cirrhosis, the diurnal plasma melatonin profile showed a significant delay in the onset of plasma melatonin increase and in its peak nocturnal level. 6 This displacement of the melatonin profile could be a reflection of an alteration in the ...

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“…Actigraphy is widely accepted as a non-invasive tool for assessing sleep-wake patterns in different groups [1][2][3], including insomnia [4,5], sleep-related breathing [6], children [7], restless legs [8], depression [9,10] and circadian rhythm disorders [11]. There is limited data, however, to show that actigraphy can reliably measure the daytime and night-time characteristics of a CNS drug.…”

Section: Introductionmentioning

confidence: 99%

Benzodiazepine‐induced reduction in activity mirrors decrements in cognitive and psychomotor performance

Dawson

Boyle

Stanley

et al. 2008

Human Psychopharmacology

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What this paper addsWhat is already knownThe evaluation of psychotropic drug effects has been conducted utilising psychometric test batteries to assess changes in daytime cognition and psychomotor functioning and PSG to assess changes in sleep. Actigraphy is widely accepted as a non-invasive tool for assessing sleep-wake patterns in different groups. However, there is limited data to show that actigraphy can reliably measure the daytime and night-time characteristics of a CNS drug. What this study adds -This study provides further evidence that actigraphy is sensitive not only to the sedating effects of a hypnotic drug but also to the hangover effects of the drug the following morning. It confirms that the actiwatch is able to detect the effects of a hypnotic on actigraphically measured sleep. Further evidence that actigraphy can provide a reliable and sensitive indication of the time course of action of psychoactive drugs. Lorazepam-induced reduction in activity 3 ABSTRACTAim: To assess whether actigraphy is sensitive to lorazepam-induced changes in cognitive and psychomotor performance by measuring activity levels following placebo and lorazepam (LZP) dosing.Methods: Healthy volunteers were randomised to a double-blind, placebocontrolled, crossover trial. Activity was recorded by actigraphy throughout each test period and pooled into 30 min bins for analysis. Following LZP dosing (2.5 mg at 18.00 h) psychomotor and cognitive tests were conducted at regular intervals.Results: Activity levels were significantly reduced between the psychometric tests (P < 0.02) at 2, 3 and 5 h post dose and during the psychometric tests (P < 0.02) at 2.5 and 4.5 h post dose. Subjects only felt sedated (P < 0.01) at 4.5 h post dose. Activity levels were also significantly reduced (P < 0.05) during sleep (23:00-07:00 h), and the following morning, activity levels remaining suppressed (P < 0.02) at 13.5 and 14 h post dose. Cognitive and psychomotor performance reflected changes in activity levels with significant impairment (P < 0.05) at 2.5, 3.5, 4.5 and 14.5 h post dose.Conclusion: This study showed that actigraphic activity levels were significantly reduced following LZP dosing. These changes were mirrored by impairment of cognitive and psychomotor performance. Actigraphy is therefore sensitive to the sedating effect of LZP and appears able to detect changes in sleep behaviour (hypnotic efficacy) and residual effects the following morning. Actigraphy may thus be a useful tool in assessing the psychopharmacology of CNS medication. Lorazepam-induced reduction in activity4

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Wrist Actigraphy in Insomnia

Cited by 290 publications

References 0 publications

Circadian function in patients with advanced non-small-cell lung cancer

Circadian function in patients with advanced non-small-cell lung cancer

High prevalence of sleep disturbance in cirrhosis

Benzodiazepine‐induced reduction in activity mirrors decrements in cognitive and psychomotor performance

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