Due to the consistent pressing quest of larger on-chip memories and caches of multicore and manycore architectures, Spin Transfer Torque Magnetic RAM (STT-MRAM or STT-RAM) has been proposed as a promising technology to replace classical SRAMs in near-future devices. Main advantages of STT-RAMs are a considerably higher transistor density and a negligible leakage power compared with SRAM technology. However, the drawback of this technology is the high probability of errors occurring especially in write operations. Such errors are asymmetric and transition-dependent, where 0 → 1 is the most critical one, and is high subjected to the amount and current (voltage) supplied to the memory during the write operation. As a consequence, STT-RAMs present an intrinsic trade-off between energy consumption vs. reliability that needs to be properly tuned w.r.t. the currently running application and its reliability requirement. This chapter proposes FlexRel, an energy-aware reliability improvement architectural scheme for STT-RAM cache memories. FlexRel considers a memory architecture provided with Error Correction Codes (ECCs) and a custom current regulator for the various cache ways and conducts a trade-off between reliability and energy consumption. FlexRel cache controller dynamically profiles the number of 0 → 1 transitions of each individual bit write operation in a cache block and based on that selects the most-suitable cache way and current level to guarantee the necessary error rate threshold (in terms of occurred write errors) while minimizing the energy consumption. We experimentally evaluated the efficiency of FlexRel against the most efficient uniform protection scheme from reliability, energy, area, and performance perspectives. Experimental simulations performed by using gem5 has demonstrated that while FlexRel satisfies the given error rate threshold, it delivers up to 13.2% energy saving. From the area footprint perspective, FlexRel delivers up to 7.9% cache ways’ area saving. Furthermore, the performance overhead of the FlexRel algorithm which changes the traffic patterns of the cache ways during the executions is 1.7%, on average.