Writing disabilities and cognitive functions at the age of nine years in a neonatal high‐risk group

Helenius, Maija

doi:10.1080/0300443870290107

Cited by 2 publications

(4 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, 23% of the affected-HB subjects reported persisting cognitive complaints at the age of 30 years, reading difficulties being reported most frequently. This is in line with the previous results at 9 years of age ( Helenius, 1987 ). In addition to learning disabilities, the subjects reported subjective ADHD symptoms more frequently than the controls.…”

Section: Resultssupporting

confidence: 94%

“…This is in line with a previous cross-sectional study of this cohort ( Michelsson, Donner & Lindahl, 1988 ). In that study, where cases under 2500 g and 35–36 weeks at birth were also included, half of the HB group presented with writing difficulties at the age of 9 years ( Helenius, 1987 ). They also had more problems at school, had lower grades, and more often attended special classes ( Michelsson, Donner & Lindahl, 1988 ).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Adult neurobehavioral outcome of hyperbilirubinemia in full term neonates—a 30 year prospective follow-up study

Hokkanen

Launes

Michelsson

2014

PeerJ

View full text Add to dashboard Cite

Background. Neonatal hyperbilirubinemia (HB) may cause severe neurological damage, but serious consequences are effectively controlled by phototherapy and blood exchange transfusion. HB is still a serious health problem in economically compromised parts of the world. The long term outcome has been regarded favorable based on epidemiological data, but has not been confirmed in prospective follow-up studies extending to adulthood.Methods. We studied the long term consequences of HB in a prospective birth cohort of 128 HB cases and 82 controls. The cases are part of a neonatal at-risk cohort (n = 1196) that has been followed up to 30 years of age. HB cases were newborns ≥ 2500 g birth weight and ≥ 37 weeks of gestation who had bilirubin concentrations > 340 µmol/l or required blood exchange transfusion. Subjects with HB were divided into subgroups based on the presence (affected HB) or absence (unaffected HB) of diagnosed neurobehavioral disorders in childhood, and compared with healthy controls. Subjects were seen at discharge, 5, 9 and 16 years of life and parent’s and teacher’s assessments were recorded. At 30 years they filled a questionnaire about academic and occupational achievement, life satisfaction, somatic and psychiatric symptoms including a ADHD self-rating score. Cognitive functioning was tested using ITPA, WISC, and reading and writing tests at 9 years of life.Results. Compared to controls, the odds for a child with HB having neurobehavioral symptoms at 9 years was elevated (OR = 4.68). Forty-five per cent of the HB group were affected by cognitive abnormalities in childhood and continued to experience problems in adulthood. This was apparent in academic achievement (p < 0.0001) and the ability to complete secondary (p < 0.0001) and tertiary (p < 0.004) education. Also, the subgroup of affected HB reported persisting cognitive complaints e.g., problems with reading, writing and mathematics. Childhood symptoms of hyperactivity/impulsivity (p < 0.0001) and inattention (p < 0.02) were more common in HB groups, but in adulthood the symptoms were equal. The affected HB had lower scores in parameters reflecting life satisfaction, less controlled drinking, but not increased substance abuse.Discussion. Our results indicate that neonatal HB has negative consequences in adult age. A prospectively collected cohort with strict inclusion criteria enables to control most of the bias factors involved with retrospective data. The control and HB groups were remarkably similar at birth in terms of medical data, and the growth environment of the children, as well as the parents’ social groups, education, size of family, type of housing at birth and at 9 years of age. Our findings bear resemblance to disorders of the fronto-striatal network, and also symptoms of the ADHD spectrum were frequent in the HB group suggesting a link of HB to other neurodevelopmental disorders.

show abstract

Section: Resultssupporting

confidence: 94%

Section: Resultsmentioning

confidence: 99%

Adult neurobehavioral outcome of hyperbilirubinemia in full term neonates—a 30 year prospective follow-up study

Hokkanen

Launes

Michelsson

2014

PeerJ

View full text Add to dashboard Cite

show abstract

“…To analyze the persistence of symptoms discovered in childhood, the subjects were categorized into two groups (affected and unaffected), based on their evaluations at 5 years and/or 9 years. We used the clinical classification that had been done prospectively for purposes of previous publications describing the children's prior development (Lindahl & Michelsson, 1986, 1987Michelsson, Ylinen, & Donner, 1981;Michelsson & Lindahl, 1984, 1987, 1993Michelsson & Noronen, 1983). The diagnostic classification in the HB group were as follows: 21% had minimal brain dysfunction (MBD) -a diagnosis in use at the beginning of the cohort study implying several concomitant deficits -30% had dyslexia, 27% perceptual disabilities (auditory, visual or undefined), 27% had motor impairment, 15% hyperactivity and attention deficit, 11% significant psychiatric and psychosomatic symptoms, 9% had neurological signs, and 5% had speech and language abnormalities (not including dyslalia only).…”

Section: Preprintsmentioning

confidence: 99%

“…This is in line with a previous cross-sectional study of this cohort . In that study, where also cases under 2500 g and 35 -36 weeks at birth were included, half of the HB group presented with writing difficulties at the age of 9 years (Helenius, 1987). They also had more problems at school, had lower grades, and more often attended special classes .…”

Section: Medical Events and Development At Birth 9 And 16 Years Of Lifementioning

confidence: 99%

Adult neurobehavioral outcome of hyperbilirubinemia in full term neonates – a 30 year prospective follow-up study

Hokkanen

Launes

Michelsson

2013

Preprint

View full text Add to dashboard Cite

Writing disabilities and cognitive functions at the age of nine years in a neonatal high‐risk group

Cited by 2 publications

References 12 publications

Adult neurobehavioral outcome of hyperbilirubinemia in full term neonates—a 30 year prospective follow-up study

Adult neurobehavioral outcome of hyperbilirubinemia in full term neonates—a 30 year prospective follow-up study

Adult neurobehavioral outcome of hyperbilirubinemia in full term neonates – a 30 year prospective follow-up study

Contact Info

Product

Resources

About